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- W2091239497 endingPage "485" @default.
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- W2091239497 abstract "Linkage disequilibrium was once a concept used little outside population genetics. However, in the genomics era it has become fundamental to our understanding of the genetic variation that is behind complex traits and evolutionary change. Linkage disequilibrium — the nonrandom association of alleles at different loci — is a sensitive indicator of the population genetic forces that structure a genome. Because of the explosive growth of methods for assessing genetic variation at a fine scale, evolutionary biologists and human geneticists are increasingly exploiting linkage disequilibrium in order to understand past evolutionary and demographic events, to map genes that are associated with quantitative characters and inherited diseases, and to understand the joint evolution of linked sets of genes. This article introduces linkage disequilibrium, reviews the population genetic processes that affect it and describes some of its uses. At present, linkage disequilibrium is used much more extensively in the study of humans than in non-humans, but that is changing as technological advances make extensive genomic studies feasible in other species." @default.
- W2091239497 created "2016-06-24" @default.
- W2091239497 creator A5067327311 @default.
- W2091239497 date "2008-06-01" @default.
- W2091239497 modified "2023-10-14" @default.
- W2091239497 title "Linkage disequilibrium — understanding the evolutionary past and mapping the medical future" @default.
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