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• W2091239605 abstract "Transforming growth factor-β (TGF-β) is the prototypic member of a superfamily of proteins important in normal growth and development. The recent molecular cloning and characterization of TGF-β receptors represents a major advance in our understanding of the mechanism of action of this cytokine. These studies have revealed that TGF-∇ elicits its diverse biological responses following the formation of a heteromeric complex involving two distantly related transmembrane serine/threonine kinases, both of which are required for signalling. Furthermore, there has been very rapid progress in the identification of key components that regulate the cell cycle, including the cyclin-dependent kinases (CDKs) and their partners, the cyclins. Perhaps the most significant development has been the isolation of a family of proteins that bind to and inactivate CDKs. The ability of TGF-β to regulate the action of these CDK inhibitors results in growth arrest of mammalian cells in G1." @default.
• W2091239605 created "2016-06-24" @default.
• W2091239605 creator A5017356449 @default.
• W2091239605 date "1996-02-05" @default.
• W2091239605 modified "2023-10-11" @default.
• W2091239605 title "TGF-β: receptors and cell cycle arrest" @default.
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• W2091239605 doi "https://doi.org/10.1016/0303-7207(95)03721-7" @default.
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