FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2091240340> ?p ?o ?g. }

• W2091240340 endingPage "2353" @default.
• W2091240340 startingPage "2340" @default.
• W2091240340 abstract "Epoxyeicosatrienoic acids (EETs), metabolites of arachidonic acid (AA) catalyzed by cytochrome P450 (CYP), have many essential biologic roles in the cardiovascular system including inhibition of apoptosis in cardiomyocytes. In the present study, we tested the potential of 8,9-EET and derivatives to protect pulmonary artery smooth muscle cells (PASMCs) from starvation induced apoptosis. We found 8,9-epoxy-eicos-11(Z)-enoic acid (8,9-EET analog (214)), but not 8,9-EET, increased cell viability, decreased activation of caspase-3 and caspase-9, and decreased TUNEL-positive cells or nuclear condensation induced by serum deprivation (SD) in PASMCs. These effects were reversed after blocking the Rho-kinase (ROCK) pathway with Y-27632 or HA-1077. Therefore, 8,9-EET analog (214) protects PASMC from serum deprivation-induced apoptosis, mediated at least in part via the ROCK pathway. Serum deprivation of PASMCs resulted in mitochondrial membrane depolarization, decreased expression of Bcl-2 and enhanced expression of Bax, all effects were reversed by 8,9-EET analog (214) in a ROCK dependent manner. Because 8,9-EET and not the 8,9-EET analog (214) protects pulmonary artery endothelial cells (PAECs), these observations suggest the potential to differentially promote apoptosis or survival with 8,9-EET or analogs in pulmonary arteries." @default.
• W2091240340 created "2016-06-24" @default.
• W2091240340 creator A5002986160 @default.
• W2091240340 creator A5010566708 @default.
• W2091240340 creator A5012092935 @default.
• W2091240340 creator A5012411069 @default.
• W2091240340 creator A5020894982 @default.
• W2091240340 creator A5025093312 @default.
• W2091240340 creator A5025528191 @default.
• W2091240340 creator A5033229269 @default.
• W2091240340 creator A5042682579 @default.
• W2091240340 creator A5054603016 @default.
• W2091240340 creator A5057304430 @default.
• W2091240340 creator A5077198825 @default.
• W2091240340 date "2010-08-01" @default.
• W2091240340 modified "2023-10-14" @default.
• W2091240340 title "8,9-Epoxyeicosatrienoic acid analog protects pulmonary artery smooth muscle cells from apoptosis via ROCK pathway" @default.
• W2091240340 cites W1745634660 @default.
• W2091240340 cites W1965925067 @default.
• W2091240340 cites W1966131269 @default.
• W2091240340 cites W1985032206 @default.
• W2091240340 cites W1998454517 @default.
• W2091240340 cites W1999155329 @default.
• W2091240340 cites W2000797437 @default.
• W2091240340 cites W2003474943 @default.
• W2091240340 cites W2004193154 @default.
• W2091240340 cites W2012055527 @default.
• W2091240340 cites W2017605264 @default.
• W2091240340 cites W2031599816 @default.
• W2091240340 cites W2051810315 @default.
• W2091240340 cites W2075339045 @default.
• W2091240340 cites W2077834462 @default.
• W2091240340 cites W2083609609 @default.
• W2091240340 cites W2088233980 @default.
• W2091240340 cites W2103196361 @default.
• W2091240340 cites W2104764277 @default.
• W2091240340 cites W2104886379 @default.
• W2091240340 cites W2105400306 @default.
• W2091240340 cites W2110506515 @default.
• W2091240340 cites W2117968545 @default.
• W2091240340 cites W2117979108 @default.
• W2091240340 cites W2119533752 @default.
• W2091240340 cites W2121378400 @default.
• W2091240340 cites W2122670147 @default.
• W2091240340 cites W2125549965 @default.
• W2091240340 cites W2129077714 @default.
• W2091240340 cites W2137508241 @default.
• W2091240340 cites W2139615329 @default.
• W2091240340 cites W2146126039 @default.
• W2091240340 cites W2157646577 @default.
• W2091240340 cites W2158421877 @default.
• W2091240340 cites W2162230936 @default.
• W2091240340 cites W2163792427 @default.
• W2091240340 cites W2168353728 @default.
• W2091240340 cites W2171420142 @default.
• W2091240340 cites W2171907478 @default.
• W2091240340 cites W2182635476 @default.
• W2091240340 cites W2184539240 @default.
• W2091240340 cites W2349327624 @default.
• W2091240340 doi "https://doi.org/10.1016/j.yexcr.2010.05.013" @default.
• W2091240340 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2927814" @default.
• W2091240340 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20493836" @default.
• W2091240340 hasPublicationYear "2010" @default.
• W2091240340 type Work @default.
• W2091240340 sameAs 2091240340 @default.
• W2091240340 citedByCount "19" @default.
• W2091240340 countsByYear W20912403402012 @default.
• W2091240340 countsByYear W20912403402013 @default.
• W2091240340 countsByYear W20912403402014 @default.
• W2091240340 countsByYear W20912403402015 @default.
• W2091240340 countsByYear W20912403402016 @default.
• W2091240340 countsByYear W20912403402017 @default.
• W2091240340 countsByYear W20912403402018 @default.
• W2091240340 countsByYear W20912403402020 @default.
• W2091240340 countsByYear W20912403402021 @default.
• W2091240340 countsByYear W20912403402022 @default.
• W2091240340 crossrefType "journal-article" @default.
• W2091240340 hasAuthorship W2091240340A5002986160 @default.
• W2091240340 hasAuthorship W2091240340A5010566708 @default.
• W2091240340 hasAuthorship W2091240340A5012092935 @default.
• W2091240340 hasAuthorship W2091240340A5012411069 @default.
• W2091240340 hasAuthorship W2091240340A5020894982 @default.
• W2091240340 hasAuthorship W2091240340A5025093312 @default.
• W2091240340 hasAuthorship W2091240340A5025528191 @default.
• W2091240340 hasAuthorship W2091240340A5033229269 @default.
• W2091240340 hasAuthorship W2091240340A5042682579 @default.
• W2091240340 hasAuthorship W2091240340A5054603016 @default.
• W2091240340 hasAuthorship W2091240340A5057304430 @default.
• W2091240340 hasAuthorship W2091240340A5077198825 @default.
• W2091240340 hasBestOaLocation W20912403402 @default.
• W2091240340 hasConcept C126322002 @default.
• W2091240340 hasConcept C134018914 @default.
• W2091240340 hasConcept C181199279 @default.
• W2091240340 hasConcept C190283241 @default.
• W2091240340 hasConcept C196795494 @default.
• W2091240340 hasConcept C2778078955 @default.
• W2091240340 hasConcept C2780940725 @default.
• W2091240340 hasConcept C29311851 @default.

• next