FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2091244266> ?p ?o ?g. }

• W2091244266 endingPage "349" @default.
• W2091244266 startingPage "333" @default.
• W2091244266 abstract "Acetylation of hemoglobin by aspirin and other acetylating agents has been used to generate hemoglobin analogs with altered structural and functional properties, and may prove useful in the treatment of sickle cell disease. We have studied the acetylation of human hemoglobin using [1′-13C]acetylsalicylic acid in combination with two-dimensional HMQC and HSQC NMR analysis. The spectra of the acetylated hemoglobin exhibit a number of well resolved resonances. Several spectral assignment strategies were used: blocking the 2,3-DPG binding site non-covalently with inositol hexaphosphate or covalently with a cross-linking agent, selective carbamylation of the N-terminal valine amino groups with cyanate, spin-labeling the hemoglobin at βCys93, and analysis of a hemoglobin triple mutant: βV1MH2ΔK144R, in which βLys144 is replaced by an arginine residue. These studies support the conclusion that the most rapidly acetylated residue is βLys82 rather than βLys144, as previously reported. Further, it is apparent that acetyl βLys82 can give rise to several resonances due to additional acetylation of βLys82′ or other nearby residues. An additional assignment strategy involving comparison of the chemical shifts of the acetyl resonances observed for adducts of diamagnetic carbonmonoxyhemoglobin with the shifts observed in paramagnetic cyanomethemoglobin provides information about the location of the acetyl derivatives relative to the heme irons. This approach is limited, however, by the lack of well defined structural information for the lysine residues on the protein surface. Additional tentative assignments have also been made, using the above approaches." @default.
• W2091244266 created "2016-06-24" @default.
• W2091244266 creator A5002756514 @default.
• W2091244266 creator A5017898253 @default.
• W2091244266 creator A5031988325 @default.
• W2091244266 creator A5056184409 @default.
• W2091244266 date "1999-07-01" @default.
• W2091244266 modified "2023-10-11" @default.
• W2091244266 title "NMR study of the sites of human hemoglobin acetylated by aspirin" @default.
• W2091244266 cites W1035484592 @default.
• W2091244266 cites W1494977501 @default.
• W2091244266 cites W1496840819 @default.
• W2091244266 cites W150843002 @default.
• W2091244266 cites W1518247336 @default.
• W2091244266 cites W1553584692 @default.
• W2091244266 cites W1584102679 @default.
• W2091244266 cites W1597160671 @default.
• W2091244266 cites W1948960263 @default.
• W2091244266 cites W1964767438 @default.
• W2091244266 cites W1967832848 @default.
• W2091244266 cites W1971966571 @default.
• W2091244266 cites W1980529383 @default.
• W2091244266 cites W1982526554 @default.
• W2091244266 cites W1994963855 @default.
• W2091244266 cites W1999585453 @default.
• W2091244266 cites W2004688222 @default.
• W2091244266 cites W2011180139 @default.
• W2091244266 cites W2021998420 @default.
• W2091244266 cites W2029642116 @default.
• W2091244266 cites W2037130547 @default.
• W2091244266 cites W2038612827 @default.
• W2091244266 cites W2044887818 @default.
• W2091244266 cites W2055240842 @default.
• W2091244266 cites W2061128078 @default.
• W2091244266 cites W2069481258 @default.
• W2091244266 cites W2072359481 @default.
• W2091244266 cites W2074736611 @default.
• W2091244266 cites W2074819974 @default.
• W2091244266 cites W2076500399 @default.
• W2091244266 cites W2077152217 @default.
• W2091244266 cites W2080826067 @default.
• W2091244266 cites W2098592308 @default.
• W2091244266 cites W2118586315 @default.
• W2091244266 cites W2149661771 @default.
• W2091244266 cites W2158576267 @default.
• W2091244266 cites W4301969733 @default.
• W2091244266 doi "https://doi.org/10.1016/s0167-4838(99)00094-1" @default.
• W2091244266 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10407155" @default.
• W2091244266 hasPublicationYear "1999" @default.
• W2091244266 type Work @default.
• W2091244266 sameAs 2091244266 @default.
• W2091244266 citedByCount "22" @default.
• W2091244266 countsByYear W20912442662012 @default.
• W2091244266 countsByYear W20912442662013 @default.
• W2091244266 countsByYear W20912442662015 @default.
• W2091244266 countsByYear W20912442662017 @default.
• W2091244266 countsByYear W20912442662018 @default.
• W2091244266 countsByYear W20912442662019 @default.
• W2091244266 countsByYear W20912442662020 @default.
• W2091244266 countsByYear W20912442662022 @default.
• W2091244266 crossrefType "journal-article" @default.
• W2091244266 hasAuthorship W2091244266A5002756514 @default.
• W2091244266 hasAuthorship W2091244266A5017898253 @default.
• W2091244266 hasAuthorship W2091244266A5031988325 @default.
• W2091244266 hasAuthorship W2091244266A5056184409 @default.
• W2091244266 hasConcept C104317684 @default.
• W2091244266 hasConcept C111429119 @default.
• W2091244266 hasConcept C119157956 @default.
• W2091244266 hasConcept C147789679 @default.
• W2091244266 hasConcept C178790620 @default.
• W2091244266 hasConcept C180577832 @default.
• W2091244266 hasConcept C181199279 @default.
• W2091244266 hasConcept C185592680 @default.
• W2091244266 hasConcept C193125475 @default.
• W2091244266 hasConcept C2776016237 @default.
• W2091244266 hasConcept C2776217839 @default.
• W2091244266 hasConcept C2777393523 @default.
• W2091244266 hasConcept C2777468819 @default.
• W2091244266 hasConcept C2777573094 @default.
• W2091244266 hasConcept C2778917026 @default.
• W2091244266 hasConcept C2779195922 @default.
• W2091244266 hasConcept C2781338088 @default.
• W2091244266 hasConcept C515207424 @default.
• W2091244266 hasConcept C55493867 @default.
• W2091244266 hasConcept C66974803 @default.
• W2091244266 hasConcept C71240020 @default.
• W2091244266 hasConceptScore W2091244266C104317684 @default.
• W2091244266 hasConceptScore W2091244266C111429119 @default.
• W2091244266 hasConceptScore W2091244266C119157956 @default.
• W2091244266 hasConceptScore W2091244266C147789679 @default.
• W2091244266 hasConceptScore W2091244266C178790620 @default.
• W2091244266 hasConceptScore W2091244266C180577832 @default.
• W2091244266 hasConceptScore W2091244266C181199279 @default.
• W2091244266 hasConceptScore W2091244266C185592680 @default.
• W2091244266 hasConceptScore W2091244266C193125475 @default.
• W2091244266 hasConceptScore W2091244266C2776016237 @default.
• W2091244266 hasConceptScore W2091244266C2776217839 @default.
• W2091244266 hasConceptScore W2091244266C2777393523 @default.

• next