FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2091244665> ?p ?o ?g. }

• W2091244665 endingPage "225" @default.
• W2091244665 startingPage "215" @default.
• W2091244665 abstract "Transglutaminase 2 (TG2) is a multifunctional member of an enzyme family: it modifies glutamine residues by cross-linking proteins and incorporating primary amines into them, has protein disulphide isomerase and protein kinase activities, mediates trans-membrane signal transduction and interactions between cell surface proteins and the extracellular matrix. These unusual multiple roles encoded into one polypeptide chain suggest that genomic variations in the TGM2 gene should be limited. Indeed, the available information in databases shows that unlike in the case of most other transglutaminases there are no common single nucleotide polymorphisms in exons of human TGM2. We collected data on and produced some of the rare genetic variants of TGM2 by site directed mutagenesis and found that some were less stable than the most abundant (wild type) enzyme variant and the majority had deficient transamidating activity. Further studies are required to clarify the pathologic significance of these rare TGM2 alleles in the human population." @default.
• W2091244665 created "2016-06-24" @default.
• W2091244665 creator A5014742619 @default.
• W2091244665 creator A5053212268 @default.
• W2091244665 creator A5082505630 @default.
• W2091244665 date "2011-12-13" @default.
• W2091244665 modified "2023-10-18" @default.
• W2091244665 title "Polymorphism of transglutaminase 2: unusually low frequency of genomic variants with deficient functions" @default.
• W2091244665 cites W1481390215 @default.
• W2091244665 cites W1526675429 @default.
• W2091244665 cites W1554807651 @default.
• W2091244665 cites W1966141691 @default.
• W2091244665 cites W1966553694 @default.
• W2091244665 cites W1973421879 @default.
• W2091244665 cites W1973950074 @default.
• W2091244665 cites W1987420957 @default.
• W2091244665 cites W1990853221 @default.
• W2091244665 cites W2011275596 @default.
• W2091244665 cites W2028654766 @default.
• W2091244665 cites W2029405287 @default.
• W2091244665 cites W2032618784 @default.
• W2091244665 cites W2040360751 @default.
• W2091244665 cites W2043087806 @default.
• W2091244665 cites W2049131474 @default.
• W2091244665 cites W2049235824 @default.
• W2091244665 cites W2052522043 @default.
• W2091244665 cites W2054517366 @default.
• W2091244665 cites W2059145105 @default.
• W2091244665 cites W2085109651 @default.
• W2091244665 cites W2090991167 @default.
• W2091244665 cites W2108779312 @default.
• W2091244665 cites W2120321361 @default.
• W2091244665 cites W2139431079 @default.
• W2091244665 cites W2143238378 @default.
• W2091244665 cites W2149992227 @default.
• W2091244665 cites W2153477152 @default.
• W2091244665 cites W2171777347 @default.
• W2091244665 cites W2220542540 @default.
• W2091244665 cites W2915827701 @default.
• W2091244665 cites W33124927 @default.
• W2091244665 cites W4240237951 @default.
• W2091244665 cites W59735862 @default.
• W2091244665 doi "https://doi.org/10.1007/s00726-011-1194-6" @default.
• W2091244665 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22160262" @default.
• W2091244665 hasPublicationYear "2011" @default.
• W2091244665 type Work @default.
• W2091244665 sameAs 2091244665 @default.
• W2091244665 citedByCount "8" @default.
• W2091244665 countsByYear W20912446652014 @default.
• W2091244665 countsByYear W20912446652015 @default.
• W2091244665 countsByYear W20912446652016 @default.
• W2091244665 countsByYear W20912446652017 @default.
• W2091244665 countsByYear W20912446652018 @default.
• W2091244665 crossrefType "journal-article" @default.
• W2091244665 hasAuthorship W2091244665A5014742619 @default.
• W2091244665 hasAuthorship W2091244665A5053212268 @default.
• W2091244665 hasAuthorship W2091244665A5082505630 @default.
• W2091244665 hasBestOaLocation W20912446652 @default.
• W2091244665 hasConcept C104317684 @default.
• W2091244665 hasConcept C144024400 @default.
• W2091244665 hasConcept C149923435 @default.
• W2091244665 hasConcept C153911025 @default.
• W2091244665 hasConcept C178498320 @default.
• W2091244665 hasConcept C180754005 @default.
• W2091244665 hasConcept C181199279 @default.
• W2091244665 hasConcept C2779349466 @default.
• W2091244665 hasConcept C2908647359 @default.
• W2091244665 hasConcept C36823959 @default.
• W2091244665 hasConcept C515207424 @default.
• W2091244665 hasConcept C54355233 @default.
• W2091244665 hasConcept C55493867 @default.
• W2091244665 hasConcept C86803240 @default.
• W2091244665 hasConceptScore W2091244665C104317684 @default.
• W2091244665 hasConceptScore W2091244665C144024400 @default.
• W2091244665 hasConceptScore W2091244665C149923435 @default.
• W2091244665 hasConceptScore W2091244665C153911025 @default.
• W2091244665 hasConceptScore W2091244665C178498320 @default.
• W2091244665 hasConceptScore W2091244665C180754005 @default.
• W2091244665 hasConceptScore W2091244665C181199279 @default.
• W2091244665 hasConceptScore W2091244665C2779349466 @default.
• W2091244665 hasConceptScore W2091244665C2908647359 @default.
• W2091244665 hasConceptScore W2091244665C36823959 @default.
• W2091244665 hasConceptScore W2091244665C515207424 @default.
• W2091244665 hasConceptScore W2091244665C54355233 @default.
• W2091244665 hasConceptScore W2091244665C55493867 @default.
• W2091244665 hasConceptScore W2091244665C86803240 @default.
• W2091244665 hasIssue "1" @default.
• W2091244665 hasLocation W20912446651 @default.
• W2091244665 hasLocation W20912446652 @default.
• W2091244665 hasLocation W20912446653 @default.
• W2091244665 hasOpenAccess W2091244665 @default.
• W2091244665 hasPrimaryLocation W20912446651 @default.
• W2091244665 hasRelatedWork W2023084705 @default.
• W2091244665 hasRelatedWork W2032161390 @default.
• W2091244665 hasRelatedWork W2057739827 @default.
• W2091244665 hasRelatedWork W2068932327 @default.
• W2091244665 hasRelatedWork W2071402592 @default.
• W2091244665 hasRelatedWork W2092938295 @default.

• next