FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2091244902> ?p ?o ?g. }

• W2091244902 endingPage "547" @default.
• W2091244902 startingPage "537" @default.
• W2091244902 abstract "In the present study, a novel GluR2 receptor-specific immunotoxin was produced. The immunotoxin was produced by conjugation of molecules of trichosanthin, a ribosome inactivating protein, with goat anti-mouse immunoglobulin molecules. The secondary antibody was then combined with a commercially available GluR2 specific primary antibody to form an immunotoxin. The immunotoxins were unilaterally injected either into the neostriatum or into the lateral ventricle of rats. After one week, ipsilateral turning movements were observed after apomorphine treatments in those animals injected by the striatal route. In perfuse-fixed sections of the neostriatum, immunoreactivity for GluR2 was found to decrease in the striatal-lesioned animals. Most of the GluR2-immunoreactive perikarya in the neostriatum, the presumed medium spiny neurons, were depleted. In addition, immunoreactivity for GluR2/3, GluR5/6/7 and NMDAR1 was found to decrease to a different extent in the lesioned neostriatum. The number of GluR1-immunoreactive perikarya in the neostriatum, a group of striatal interneurons, was not affected by the GluR2 lesion. Ventricular administration of the GluR2 immunotoxin however, was found to be less potent. These results demonstrate for the first time that an indirect immunotoxin is useful for immunolesioning. A difference in potency was also observed in different routes of administration. The depletion of GluR2-containing medium spiny neurons in the neostriatum may upset the balance of the output systems of the basal ganglia and has a profound effect in movement control of the animals." @default.
• W2091244902 created "2016-06-24" @default.
• W2091244902 creator A5026357816 @default.
• W2091244902 creator A5044906953 @default.
• W2091244902 creator A5067615428 @default.
• W2091244902 date "2000-03-01" @default.
• W2091244902 modified "2023-09-26" @default.
• W2091244902 title "Depletion of glutamate GluR2 receptor-containing neurons in the rat neostriatum by specific immunotoxin" @default.
• W2091244902 cites W1497318553 @default.
• W2091244902 cites W1526327880 @default.
• W2091244902 cites W1661264368 @default.
• W2091244902 cites W1797028971 @default.
• W2091244902 cites W1813932451 @default.
• W2091244902 cites W1930427841 @default.
• W2091244902 cites W1966768311 @default.
• W2091244902 cites W1972183007 @default.
• W2091244902 cites W1972718612 @default.
• W2091244902 cites W1974424738 @default.
• W2091244902 cites W1985927343 @default.
• W2091244902 cites W1989938166 @default.
• W2091244902 cites W1999968276 @default.
• W2091244902 cites W2003625937 @default.
• W2091244902 cites W2004567663 @default.
• W2091244902 cites W2015721558 @default.
• W2091244902 cites W2015956155 @default.
• W2091244902 cites W2016023867 @default.
• W2091244902 cites W2018285470 @default.
• W2091244902 cites W2022233762 @default.
• W2091244902 cites W2033949713 @default.
• W2091244902 cites W2034171869 @default.
• W2091244902 cites W2038295594 @default.
• W2091244902 cites W2038570330 @default.
• W2091244902 cites W2045883173 @default.
• W2091244902 cites W2049123563 @default.
• W2091244902 cites W2052128851 @default.
• W2091244902 cites W2053629010 @default.
• W2091244902 cites W2055133784 @default.
• W2091244902 cites W2060588252 @default.
• W2091244902 cites W2076331416 @default.
• W2091244902 cites W2087593804 @default.
• W2091244902 cites W2087989670 @default.
• W2091244902 cites W2110534885 @default.
• W2091244902 cites W2116058571 @default.
• W2091244902 cites W2122946342 @default.
• W2091244902 cites W2128304152 @default.
• W2091244902 cites W2129108032 @default.
• W2091244902 cites W2132918777 @default.
• W2091244902 cites W2133052659 @default.
• W2091244902 cites W2147169944 @default.
• W2091244902 cites W2147561535 @default.
• W2091244902 cites W2148934600 @default.
• W2091244902 cites W2162532681 @default.
• W2091244902 cites W2212032914 @default.
• W2091244902 cites W221359381 @default.
• W2091244902 cites W2282756140 @default.
• W2091244902 cites W230369074 @default.
• W2091244902 cites W2399949429 @default.
• W2091244902 cites W244336710 @default.
• W2091244902 cites W2493460545 @default.
• W2091244902 cites W3140389668 @default.
• W2091244902 cites W55797177 @default.
• W2091244902 cites W83092416 @default.
• W2091244902 cites W2076211518 @default.
• W2091244902 doi "https://doi.org/10.1016/s0306-4522(99)00564-3" @default.
• W2091244902 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10717434" @default.
• W2091244902 hasPublicationYear "2000" @default.
• W2091244902 type Work @default.
• W2091244902 sameAs 2091244902 @default.
• W2091244902 citedByCount "5" @default.
• W2091244902 crossrefType "journal-article" @default.
• W2091244902 hasAuthorship W2091244902A5026357816 @default.
• W2091244902 hasAuthorship W2091244902A5044906953 @default.
• W2091244902 hasAuthorship W2091244902A5067615428 @default.
• W2091244902 hasConcept C115085202 @default.
• W2091244902 hasConcept C126322002 @default.
• W2091244902 hasConcept C134018914 @default.
• W2091244902 hasConcept C153911025 @default.
• W2091244902 hasConcept C159654299 @default.
• W2091244902 hasConcept C160268369 @default.
• W2091244902 hasConcept C169760540 @default.
• W2091244902 hasConcept C170493617 @default.
• W2091244902 hasConcept C185592680 @default.
• W2091244902 hasConcept C203014093 @default.
• W2091244902 hasConcept C2778187257 @default.
• W2091244902 hasConcept C529278444 @default.
• W2091244902 hasConcept C542903549 @default.
• W2091244902 hasConcept C55493867 @default.
• W2091244902 hasConcept C61174792 @default.
• W2091244902 hasConcept C67018056 @default.
• W2091244902 hasConcept C71924100 @default.
• W2091244902 hasConcept C86803240 @default.
• W2091244902 hasConceptScore W2091244902C115085202 @default.
• W2091244902 hasConceptScore W2091244902C126322002 @default.
• W2091244902 hasConceptScore W2091244902C134018914 @default.
• W2091244902 hasConceptScore W2091244902C153911025 @default.
• W2091244902 hasConceptScore W2091244902C159654299 @default.
• W2091244902 hasConceptScore W2091244902C160268369 @default.
• W2091244902 hasConceptScore W2091244902C169760540 @default.

• next