FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2091245150> ?p ?o ?g. }

• W2091245150 endingPage "1469" @default.
• W2091245150 startingPage "1465" @default.
• W2091245150 abstract "Glucose-6-phosphate dehydrogenase (G6PD) is a ubiquitous enzyme that supplies the cell with NADPH required for a variety of reductive reactions and biosynthetic processes. Therefore, the gene G6PD, located in mammals on the X chromosome, that specifies G6PD can be regarded as a typical housekeeping gene. We have investigated the expression of human G6PD in eight different fetal and adult tissues by determining the level of enzyme activity, the level of G6PD mRNA, and the methylation pattern of the 3' end of the gene, for which we have nucleic acid probes. By combining sequence information with results of Southern blot analysis of DNA samples digested with the methylation-sensitive restriction enzyme Hpa II, we have identified five specific sites that are unmethylated in all tissues examined, a number of sites that are uniformly methylated, and a number of sites that are sometimes methylated. A subset of Hpa II sites, designated on our restriction map as H37-H55, exhibit positive correlation between degree of methylation, level of mRNA, and level of G6PD activity. A comparison of these methylation patterns with those we previously have observed in the G6PD gene on the inactive X chromosome [Toniolo, D., D'Urso, M., Martini, G., Persico, M.G., Tufano, V., Battistuzzi, G. & Luzzatto, L. (1984) EMBO J. 3, 1987-1995] indicates that different sites are associated with X-inactivation and with the regulation of G6PD on the active X chromosome. We conclude that this housekeeping gene is subject to tissue-specific transcriptional regulation, which in turn correlates with methylation of specific sites located at and near the 3' end of the gene." @default.
• W2091245150 created "2016-06-24" @default.
• W2091245150 creator A5005563599 @default.
• W2091245150 creator A5007348472 @default.
• W2091245150 creator A5035008597 @default.
• W2091245150 creator A5035828284 @default.
• W2091245150 creator A5048435323 @default.
• W2091245150 date "1985-03-01" @default.
• W2091245150 modified "2023-10-14" @default.
• W2091245150 title "Tissue-specific levels of human glucose-6-phosphate dehydrogenase correlate with methylation of specific sites at the 3' end of the gene." @default.
• W2091245150 cites W112406711 @default.
• W2091245150 cites W116234609 @default.
• W2091245150 cites W1510707687 @default.
• W2091245150 cites W1564857046 @default.
• W2091245150 cites W193699753 @default.
• W2091245150 cites W1968793650 @default.
• W2091245150 cites W2000339480 @default.
• W2091245150 cites W2012046043 @default.
• W2091245150 cites W2023513664 @default.
• W2091245150 cites W2023962194 @default.
• W2091245150 cites W2027409002 @default.
• W2091245150 cites W2037818515 @default.
• W2091245150 cites W2038734404 @default.
• W2091245150 cites W2055025630 @default.
• W2091245150 cites W2060333964 @default.
• W2091245150 cites W2065404667 @default.
• W2091245150 cites W2066160869 @default.
• W2091245150 cites W2093908800 @default.
• W2091245150 cites W2128635872 @default.
• W2091245150 cites W2160821245 @default.
• W2091245150 cites W3166601379 @default.
• W2091245150 cites W81152036 @default.
• W2091245150 cites W94005661 @default.
• W2091245150 doi "https://doi.org/10.1073/pnas.82.5.1465" @default.
• W2091245150 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/397283" @default.
• W2091245150 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3856275" @default.
• W2091245150 hasPublicationYear "1985" @default.
• W2091245150 type Work @default.
• W2091245150 sameAs 2091245150 @default.
• W2091245150 citedByCount "65" @default.
• W2091245150 countsByYear W20912451502012 @default.
• W2091245150 countsByYear W20912451502014 @default.
• W2091245150 countsByYear W20912451502019 @default.
• W2091245150 countsByYear W20912451502020 @default.
• W2091245150 countsByYear W20912451502021 @default.
• W2091245150 countsByYear W20912451502022 @default.
• W2091245150 crossrefType "journal-article" @default.
• W2091245150 hasAuthorship W2091245150A5005563599 @default.
• W2091245150 hasAuthorship W2091245150A5007348472 @default.
• W2091245150 hasAuthorship W2091245150A5035008597 @default.
• W2091245150 hasAuthorship W2091245150A5035828284 @default.
• W2091245150 hasAuthorship W2091245150A5048435323 @default.
• W2091245150 hasBestOaLocation W20912451501 @default.
• W2091245150 hasConcept C104317684 @default.
• W2091245150 hasConcept C128319531 @default.
• W2091245150 hasConcept C140173407 @default.
• W2091245150 hasConcept C150194340 @default.
• W2091245150 hasConcept C153911025 @default.
• W2091245150 hasConcept C181199279 @default.
• W2091245150 hasConcept C190727270 @default.
• W2091245150 hasConcept C2776317432 @default.
• W2091245150 hasConcept C2780196906 @default.
• W2091245150 hasConcept C33288867 @default.
• W2091245150 hasConcept C33922130 @default.
• W2091245150 hasConcept C35158069 @default.
• W2091245150 hasConcept C55493867 @default.
• W2091245150 hasConcept C86803240 @default.
• W2091245150 hasConceptScore W2091245150C104317684 @default.
• W2091245150 hasConceptScore W2091245150C128319531 @default.
• W2091245150 hasConceptScore W2091245150C140173407 @default.
• W2091245150 hasConceptScore W2091245150C150194340 @default.
• W2091245150 hasConceptScore W2091245150C153911025 @default.
• W2091245150 hasConceptScore W2091245150C181199279 @default.
• W2091245150 hasConceptScore W2091245150C190727270 @default.
• W2091245150 hasConceptScore W2091245150C2776317432 @default.
• W2091245150 hasConceptScore W2091245150C2780196906 @default.
• W2091245150 hasConceptScore W2091245150C33288867 @default.
• W2091245150 hasConceptScore W2091245150C33922130 @default.
• W2091245150 hasConceptScore W2091245150C35158069 @default.
• W2091245150 hasConceptScore W2091245150C55493867 @default.
• W2091245150 hasConceptScore W2091245150C86803240 @default.
• W2091245150 hasIssue "5" @default.
• W2091245150 hasLocation W20912451501 @default.
• W2091245150 hasLocation W20912451502 @default.
• W2091245150 hasLocation W20912451503 @default.
• W2091245150 hasLocation W20912451504 @default.
• W2091245150 hasOpenAccess W2091245150 @default.
• W2091245150 hasPrimaryLocation W20912451501 @default.
• W2091245150 hasRelatedWork W1969720359 @default.
• W2091245150 hasRelatedWork W2004256856 @default.
• W2091245150 hasRelatedWork W2038831974 @default.
• W2091245150 hasRelatedWork W2091245150 @default.
• W2091245150 hasRelatedWork W2144473770 @default.
• W2091245150 hasRelatedWork W2521707600 @default.
• W2091245150 hasRelatedWork W2764270135 @default.
• W2091245150 hasRelatedWork W2922963799 @default.
• W2091245150 hasRelatedWork W4283027398 @default.
• W2091245150 hasRelatedWork W779414787 @default.

• next