FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2091245746> ?p ?o ?g. }

• W2091245746 endingPage "249" @default.
• W2091245746 startingPage "243" @default.
• W2091245746 abstract "The effects of glucose deprivation on cerebral blood flow (CBF) have been extensively investigated during insulin-induced hypoglycemia in laboratory animals. Pharmacological doses of glucose analog, 2-deoxyglucose (2DG), is an alternative glucoprivic agent that in contrast to insulin, directly inhibits glycolysis and glucose utilization. Both glucoprivic conditions markedly increase CBF in laboratory animals. How 2DG affects CBF in humans is still undetermined. In the present study we have employed H215O positron emission tomography (PET) to examine the effects of pharmacological doses of 2DG (40 mg/kg) on regional and global cerebral blood flow in 10 brain areas in 13 healthy volunteers. 2DG administration significantly raised regional CBF (rCBF) in the cingulate gyrus, sensorimotor cortex, superior temporal cortex, occipital cortex, basal ganglia, limbic system and hypothalamus. 2DG produced a trend towards elevated CBF in whole brain and frontal cortex, while no changes were observed in the corpus callosum and thalamus. In addition, 2DG significantly decreased body temperature and mean arterial pressure (MAP). Maximal percent changes in hypothalamic rCBF were significantly correlated with maximal changes in body temperature but not with MAP. These results indicate that cerebral glucoprivation produced by pharmacological doses of 2DG is accompanied by widespread activation of cortical and subcortical blood flow and that the blood flow changes in the hypothalamus may be related to 2DG-induced hypothermia." @default.
• W2091245746 created "2016-06-24" @default.
• W2091245746 creator A5026259953 @default.
• W2091245746 creator A5031396815 @default.
• W2091245746 creator A5053492994 @default.
• W2091245746 creator A5056032971 @default.
• W2091245746 creator A5067068796 @default.
• W2091245746 date "1999-01-01" @default.
• W2091245746 modified "2023-09-25" @default.
• W2091245746 title "The effects of pharmacological doses of 2-deoxyglucose on cerebral blood flow in healthy volunteers" @default.
• W2091245746 cites W1963942664 @default.
• W2091245746 cites W1972539879 @default.
• W2091245746 cites W1980167949 @default.
• W2091245746 cites W1988147369 @default.
• W2091245746 cites W1990005524 @default.
• W2091245746 cites W1998843956 @default.
• W2091245746 cites W2001263071 @default.
• W2091245746 cites W2002377016 @default.
• W2091245746 cites W2009051828 @default.
• W2091245746 cites W2010632062 @default.
• W2091245746 cites W2011886251 @default.
• W2091245746 cites W2025683639 @default.
• W2091245746 cites W2035812587 @default.
• W2091245746 cites W2036800750 @default.
• W2091245746 cites W2038782045 @default.
• W2091245746 cites W2043465948 @default.
• W2091245746 cites W2043889745 @default.
• W2091245746 cites W2044938483 @default.
• W2091245746 cites W2050271957 @default.
• W2091245746 cites W2051809205 @default.
• W2091245746 cites W2071860388 @default.
• W2091245746 cites W2079637016 @default.
• W2091245746 cites W2083920864 @default.
• W2091245746 cites W2093219766 @default.
• W2091245746 cites W2139792242 @default.
• W2091245746 cites W2139880301 @default.
• W2091245746 cites W2322414185 @default.
• W2091245746 cites W4294730249 @default.
• W2091245746 doi "https://doi.org/10.1016/s0006-8993(98)01137-8" @default.
• W2091245746 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9878763" @default.
• W2091245746 hasPublicationYear "1999" @default.
• W2091245746 type Work @default.
• W2091245746 sameAs 2091245746 @default.
• W2091245746 citedByCount "25" @default.
• W2091245746 countsByYear W20912457462012 @default.
• W2091245746 countsByYear W20912457462013 @default.
• W2091245746 countsByYear W20912457462015 @default.
• W2091245746 countsByYear W20912457462017 @default.
• W2091245746 countsByYear W20912457462018 @default.
• W2091245746 countsByYear W20912457462019 @default.
• W2091245746 countsByYear W20912457462020 @default.
• W2091245746 countsByYear W20912457462021 @default.
• W2091245746 countsByYear W20912457462023 @default.
• W2091245746 crossrefType "journal-article" @default.
• W2091245746 hasAuthorship W2091245746A5026259953 @default.
• W2091245746 hasAuthorship W2091245746A5031396815 @default.
• W2091245746 hasAuthorship W2091245746A5053492994 @default.
• W2091245746 hasAuthorship W2091245746A5056032971 @default.
• W2091245746 hasAuthorship W2091245746A5067068796 @default.
• W2091245746 hasConcept C126322002 @default.
• W2091245746 hasConcept C134018914 @default.
• W2091245746 hasConcept C15744967 @default.
• W2091245746 hasConcept C157767197 @default.
• W2091245746 hasConcept C158846371 @default.
• W2091245746 hasConcept C169760540 @default.
• W2091245746 hasConcept C2777003273 @default.
• W2091245746 hasConcept C2777348757 @default.
• W2091245746 hasConcept C2777866211 @default.
• W2091245746 hasConcept C2779246727 @default.
• W2091245746 hasConcept C2779306644 @default.
• W2091245746 hasConcept C2779369059 @default.
• W2091245746 hasConcept C2780909259 @default.
• W2091245746 hasConcept C2781041448 @default.
• W2091245746 hasConcept C2781210436 @default.
• W2091245746 hasConcept C529278444 @default.
• W2091245746 hasConcept C71924100 @default.
• W2091245746 hasConceptScore W2091245746C126322002 @default.
• W2091245746 hasConceptScore W2091245746C134018914 @default.
• W2091245746 hasConceptScore W2091245746C15744967 @default.
• W2091245746 hasConceptScore W2091245746C157767197 @default.
• W2091245746 hasConceptScore W2091245746C158846371 @default.
• W2091245746 hasConceptScore W2091245746C169760540 @default.
• W2091245746 hasConceptScore W2091245746C2777003273 @default.
• W2091245746 hasConceptScore W2091245746C2777348757 @default.
• W2091245746 hasConceptScore W2091245746C2777866211 @default.
• W2091245746 hasConceptScore W2091245746C2779246727 @default.
• W2091245746 hasConceptScore W2091245746C2779306644 @default.
• W2091245746 hasConceptScore W2091245746C2779369059 @default.
• W2091245746 hasConceptScore W2091245746C2780909259 @default.
• W2091245746 hasConceptScore W2091245746C2781041448 @default.
• W2091245746 hasConceptScore W2091245746C2781210436 @default.
• W2091245746 hasConceptScore W2091245746C529278444 @default.
• W2091245746 hasConceptScore W2091245746C71924100 @default.
• W2091245746 hasIssue "2" @default.
• W2091245746 hasLocation W20912457461 @default.
• W2091245746 hasLocation W20912457462 @default.
• W2091245746 hasOpenAccess W2091245746 @default.
• W2091245746 hasPrimaryLocation W20912457461 @default.

• next