Matches in SemOpenAlex for { <https://semopenalex.org/work/W2091246647> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W2091246647 endingPage "1720" @default.
- W2091246647 startingPage "1715" @default.
- W2091246647 abstract "Cholyl adenylate is a putative intermediate for biosynthesis of cholic acid-coenzyme A (CoA) thioester conjugates by acyl-CoA synthetase. Early studies showed the conjugated acid anhydride moiety of cholyl adenylate to be reactive, attacking proteins to form protein-cholic acid adducts. In the present study, to clarify reactions of cholyl adenylate with DNA under physiological conditions, products with nucleosides were analyzed. HPLC-MS analyses indicated cholyl adenylate to primarily attack hydroxy groups of ribose moieties of nucleosides. Moreover, as speculated from UV and MS studies, exocyclic amino groups of 2'-deoxycytidine and 2'-deoxyadenosine were found to serve as targets of cholyl adenylate; the corresponding cholic amides, N4-cholyl-2'-deoxycytidine and N6-cholyl-2'-deoxyadenosine, were formed at yields of 0.32 and 0.06%, respectively. Structures of these base modified adducts were confirmed by direct comparison with synthetic compounds obtained from coupling reactions of cholic acid with each nucleoside in the presence of dicyclohexylcarbodiimide in pyridine at 70 degrees C. N4-Cholyl-2'-deoxycytidine was also obtained at a level of 1.6 adducts per 10(5) nucleosides from enzymatic hydrolysates of calf thymus DNA reacted with cholyl adenylate. These results suggest that cholyl adenylate, released from CoA synthetase, may have some possibility as a DNA modifier in vivo." @default.
- W2091246647 created "2016-06-24" @default.
- W2091246647 creator A5000409879 @default.
- W2091246647 creator A5035220084 @default.
- W2091246647 creator A5053524893 @default.
- W2091246647 creator A5063732330 @default.
- W2091246647 creator A5081353624 @default.
- W2091246647 date "2005-09-29" @default.
- W2091246647 modified "2023-09-23" @default.
- W2091246647 title "Formation of DNA Adducts with Cholyl Adenylate, a Putative Intermediate for Biosynthesis of Cholyl-CoA" @default.
- W2091246647 cites W1945606056 @default.
- W2091246647 cites W1988934335 @default.
- W2091246647 cites W2031018231 @default.
- W2091246647 cites W2043722003 @default.
- W2091246647 cites W2087563317 @default.
- W2091246647 cites W2145891424 @default.
- W2091246647 doi "https://doi.org/10.1021/tx050159v" @default.
- W2091246647 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16300380" @default.
- W2091246647 hasPublicationYear "2005" @default.
- W2091246647 type Work @default.
- W2091246647 sameAs 2091246647 @default.
- W2091246647 citedByCount "1" @default.
- W2091246647 countsByYear W20912466472013 @default.
- W2091246647 crossrefType "journal-article" @default.
- W2091246647 hasAuthorship W2091246647A5000409879 @default.
- W2091246647 hasAuthorship W2091246647A5035220084 @default.
- W2091246647 hasAuthorship W2091246647A5053524893 @default.
- W2091246647 hasAuthorship W2091246647A5063732330 @default.
- W2091246647 hasAuthorship W2091246647A5081353624 @default.
- W2091246647 hasConcept C108204754 @default.
- W2091246647 hasConcept C178790620 @default.
- W2091246647 hasConcept C180526460 @default.
- W2091246647 hasConcept C181199279 @default.
- W2091246647 hasConcept C185592680 @default.
- W2091246647 hasConcept C2775900799 @default.
- W2091246647 hasConcept C2776543447 @default.
- W2091246647 hasConcept C2779399885 @default.
- W2091246647 hasConcept C2780636463 @default.
- W2091246647 hasConcept C552990157 @default.
- W2091246647 hasConcept C553450214 @default.
- W2091246647 hasConcept C55493867 @default.
- W2091246647 hasConcept C71240020 @default.
- W2091246647 hasConceptScore W2091246647C108204754 @default.
- W2091246647 hasConceptScore W2091246647C178790620 @default.
- W2091246647 hasConceptScore W2091246647C180526460 @default.
- W2091246647 hasConceptScore W2091246647C181199279 @default.
- W2091246647 hasConceptScore W2091246647C185592680 @default.
- W2091246647 hasConceptScore W2091246647C2775900799 @default.
- W2091246647 hasConceptScore W2091246647C2776543447 @default.
- W2091246647 hasConceptScore W2091246647C2779399885 @default.
- W2091246647 hasConceptScore W2091246647C2780636463 @default.
- W2091246647 hasConceptScore W2091246647C552990157 @default.
- W2091246647 hasConceptScore W2091246647C553450214 @default.
- W2091246647 hasConceptScore W2091246647C55493867 @default.
- W2091246647 hasConceptScore W2091246647C71240020 @default.
- W2091246647 hasIssue "11" @default.
- W2091246647 hasLocation W20912466471 @default.
- W2091246647 hasLocation W20912466472 @default.
- W2091246647 hasOpenAccess W2091246647 @default.
- W2091246647 hasPrimaryLocation W20912466471 @default.
- W2091246647 hasRelatedWork W1977915969 @default.
- W2091246647 hasRelatedWork W2032712850 @default.
- W2091246647 hasRelatedWork W2034979205 @default.
- W2091246647 hasRelatedWork W2049862580 @default.
- W2091246647 hasRelatedWork W2055683447 @default.
- W2091246647 hasRelatedWork W2057342326 @default.
- W2091246647 hasRelatedWork W2079902812 @default.
- W2091246647 hasRelatedWork W2091246060 @default.
- W2091246647 hasRelatedWork W2091246647 @default.
- W2091246647 hasRelatedWork W2425651633 @default.
- W2091246647 hasVolume "18" @default.
- W2091246647 isParatext "false" @default.
- W2091246647 isRetracted "false" @default.
- W2091246647 magId "2091246647" @default.
- W2091246647 workType "article" @default.