Matches in SemOpenAlex for { <https://semopenalex.org/work/W2091246703> ?p ?o ?g. }
- W2091246703 endingPage "891" @default.
- W2091246703 startingPage "883" @default.
- W2091246703 abstract "Neuronal dense-core vesicles (DCVs) contain diverse cargo crucial for brain development and function, but the mechanisms that control their release are largely unknown. We quantified activity-dependent DCV release in hippocampal neurons at single vesicle resolution. DCVs fused preferentially at synaptic terminals. DCVs also fused at extrasynaptic sites but only after prolonged stimulation. In munc13-1/2-null mutant neurons, synaptic DCV release was reduced but not abolished, and synaptic preference was lost. The remaining fusion required prolonged stimulation, similar to extrasynaptic fusion in wild-type neurons. Conversely, Munc13-1 overexpression (M13OE) promoted extrasynaptic DCV release, also without prolonged stimulation. Thus, Munc13-1/2 facilitate DCV fusion but, unlike for synaptic vesicles, are not essential for DCV release, and M13OE is sufficient to produce efficient DCV release extrasynaptically." @default.
- W2091246703 created "2016-06-24" @default.
- W2091246703 creator A5008564461 @default.
- W2091246703 creator A5010888575 @default.
- W2091246703 creator A5026872836 @default.
- W2091246703 creator A5033236275 @default.
- W2091246703 creator A5035408516 @default.
- W2091246703 creator A5071375747 @default.
- W2091246703 creator A5089923593 @default.
- W2091246703 date "2012-12-10" @default.
- W2091246703 modified "2023-10-15" @default.
- W2091246703 title "Munc13 controls the location and efficiency of dense-core vesicle release in neurons" @default.
- W2091246703 cites W1536527949 @default.
- W2091246703 cites W1600427108 @default.
- W2091246703 cites W1618714882 @default.
- W2091246703 cites W1968170941 @default.
- W2091246703 cites W1974684242 @default.
- W2091246703 cites W1988793243 @default.
- W2091246703 cites W2000302106 @default.
- W2091246703 cites W2009867542 @default.
- W2091246703 cites W2014609146 @default.
- W2091246703 cites W2014696861 @default.
- W2091246703 cites W2021836727 @default.
- W2091246703 cites W2023636464 @default.
- W2091246703 cites W2024136850 @default.
- W2091246703 cites W2029565457 @default.
- W2091246703 cites W2031522258 @default.
- W2091246703 cites W2032125422 @default.
- W2091246703 cites W2035441746 @default.
- W2091246703 cites W2039210066 @default.
- W2091246703 cites W2040866860 @default.
- W2091246703 cites W2045798452 @default.
- W2091246703 cites W2052309340 @default.
- W2091246703 cites W2053108820 @default.
- W2091246703 cites W2060910300 @default.
- W2091246703 cites W2061342956 @default.
- W2091246703 cites W2065171944 @default.
- W2091246703 cites W2076220928 @default.
- W2091246703 cites W2078936926 @default.
- W2091246703 cites W2086919645 @default.
- W2091246703 cites W2087225287 @default.
- W2091246703 cites W2090689542 @default.
- W2091246703 cites W2093467598 @default.
- W2091246703 cites W2094544368 @default.
- W2091246703 cites W2120651612 @default.
- W2091246703 cites W2121699552 @default.
- W2091246703 cites W2124045323 @default.
- W2091246703 cites W2139266146 @default.
- W2091246703 cites W2139565721 @default.
- W2091246703 cites W2141315977 @default.
- W2091246703 cites W2154100802 @default.
- W2091246703 cites W2156715598 @default.
- W2091246703 cites W2157623413 @default.
- W2091246703 cites W2158456505 @default.
- W2091246703 cites W2161367731 @default.
- W2091246703 cites W2162954233 @default.
- W2091246703 cites W2163639252 @default.
- W2091246703 cites W2170349574 @default.
- W2091246703 cites W2176298095 @default.
- W2091246703 cites W2018312538 @default.
- W2091246703 doi "https://doi.org/10.1083/jcb.201208024" @default.
- W2091246703 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3518216" @default.
- W2091246703 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23229896" @default.
- W2091246703 hasPublicationYear "2012" @default.
- W2091246703 type Work @default.
- W2091246703 sameAs 2091246703 @default.
- W2091246703 citedByCount "77" @default.
- W2091246703 countsByYear W20912467032012 @default.
- W2091246703 countsByYear W20912467032014 @default.
- W2091246703 countsByYear W20912467032015 @default.
- W2091246703 countsByYear W20912467032016 @default.
- W2091246703 countsByYear W20912467032017 @default.
- W2091246703 countsByYear W20912467032018 @default.
- W2091246703 countsByYear W20912467032019 @default.
- W2091246703 countsByYear W20912467032020 @default.
- W2091246703 countsByYear W20912467032021 @default.
- W2091246703 countsByYear W20912467032022 @default.
- W2091246703 countsByYear W20912467032023 @default.
- W2091246703 crossrefType "journal-article" @default.
- W2091246703 hasAuthorship W2091246703A5008564461 @default.
- W2091246703 hasAuthorship W2091246703A5010888575 @default.
- W2091246703 hasAuthorship W2091246703A5026872836 @default.
- W2091246703 hasAuthorship W2091246703A5033236275 @default.
- W2091246703 hasAuthorship W2091246703A5035408516 @default.
- W2091246703 hasAuthorship W2091246703A5071375747 @default.
- W2091246703 hasAuthorship W2091246703A5089923593 @default.
- W2091246703 hasBestOaLocation W20912467031 @default.
- W2091246703 hasConcept C12554922 @default.
- W2091246703 hasConcept C127445978 @default.
- W2091246703 hasConcept C130316041 @default.
- W2091246703 hasConcept C148762608 @default.
- W2091246703 hasConcept C148785051 @default.
- W2091246703 hasConcept C169760540 @default.
- W2091246703 hasConcept C196330066 @default.
- W2091246703 hasConcept C24998067 @default.
- W2091246703 hasConcept C2909863526 @default.
- W2091246703 hasConcept C41625074 @default.
- W2091246703 hasConcept C55493867 @default.