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- W2091246706 abstract "Erythroid Krüppel‐like factor (EKLF/KLF1) is an erythroid specific, C 2 H 2 zinc finger transcription factor that is essential for the proper chromatin structure and expression of the adult β‐globin gene. Herein, we determine that 26S proteasome inhibitors lead to an accumulation of EKLF protein in murine erythroleukemia (MEL) cells. In addition, EKLF half‐life in both MEL cells (<3 h) and fetal liver cells (between 6 and 9 h) is stabilized in the presence of these inhibitors. EKLF is ubiquitinated in vivo, however its modification does not rely on a particular internal lysine. Finally, EKLF contains two PEST sequences within its N‐terminus that have no effect on the ability of EKLF to be ubiquitinated but contribute to its destabilization." @default.
- W2091246706 created "2016-06-24" @default.
- W2091246706 creator A5002966230 @default.
- W2091246706 creator A5055094777 @default.
- W2091246706 date "2006-03-24" @default.
- W2091246706 modified "2023-10-15" @default.
- W2091246706 title "EKLF/KLF1 is ubiquitinated in vivo and its stability is regulated by activation domain sequences through the 26S proteasome" @default.
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- W2091246706 doi "https://doi.org/10.1016/j.febslet.2006.03.039" @default.
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