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- W2091247079 abstract "The immune system is implicated in the pathophysiology of various psychiatric disorders. In anxiety disorders such as obsessive-compulsive disorder (OCD) and generalized social anxiety disorder (GSAD), immunological findings are equivocal and sparse. In this study, we investigated the lipopolysaccharide (LPS)- stimulated cytokine levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and interleukin-8 (IL-8) by peripheral blood leukocytes in 26 OCD patients, 26 GSAD patients, and 52 healthy controls. We found that leukocytes of OCD patients produced less IL-6 compared with matched controls, whereas no cytokine differences were found between GSAD patients and matched controls. When both patient groups were compared, a trend toward lower IL-6 levels in OCD patients was observed. This supports the idea of immunological involvement in the pathophysiology of OCD and suggests that GSAD and OCD might be different in immunological respect." @default.
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- W2091247079 date "2010-07-01" @default.
- W2091247079 modified "2023-10-01" @default.
- W2091247079 title "Lipopolysaccharide-induced cytokine production in obsessive–compulsive disorder and generalized social anxiety disorder" @default.
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- W2091247079 doi "https://doi.org/10.1016/j.psychres.2009.05.008" @default.
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