Matches in SemOpenAlex for { <https://semopenalex.org/work/W2091247151> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W2091247151 endingPage "6271" @default.
- W2091247151 startingPage "6267" @default.
- W2091247151 abstract "We report a mutational analysis of the chicken beta-globin enhancer, using transient expression in primary embryonic erythrocytes. A series of 27 scanning mutants differing only by consecutive 4-base substitutions was tested. Previous experiments, using protection from DNase I digestion, demonstrated four regions in the enhancer that bind factors. Mutations in two of the four regions (denoted I and III) have no effect on enhancer activity. The other two regions (II and IV) mediate all of the positive-acting activity. Region II appears to consist of two subregions, mutation in either of which leads to the same loss in activity as mutation of both. Like region II, mutation of either half of region IV results in reduced enhancer activity. However, in contrast to region II, mutation of both halves of region IV results in more loss of enhancer activity than either single mutation. These data suggest that the half-sites in region II must interact in order to cause enhancement, whereas the half-sites in region IV act independently. Triplications of regions II or IV are able to enhance to a similar degree as the parental enhancer, but single copies of regions II or IV enhance only weakly. Thus, as measured by transient expression in embryonic erythrocytes, the beta-globin enhancer may involve the action of as few as three DNA-binding proteins acting at two sites." @default.
- W2091247151 created "2016-06-24" @default.
- W2091247151 creator A5037088178 @default.
- W2091247151 creator A5062031732 @default.
- W2091247151 date "1988-09-01" @default.
- W2091247151 modified "2023-10-13" @default.
- W2091247151 title "Mutational analysis of the chicken beta-globin enhancer reveals two positive-acting domains." @default.
- W2091247151 cites W126863029 @default.
- W2091247151 cites W1597916030 @default.
- W2091247151 cites W1967004332 @default.
- W2091247151 cites W1983191015 @default.
- W2091247151 cites W1990045705 @default.
- W2091247151 cites W1993214904 @default.
- W2091247151 cites W1993704650 @default.
- W2091247151 cites W1994970763 @default.
- W2091247151 cites W1998844870 @default.
- W2091247151 cites W2003893812 @default.
- W2091247151 cites W2004811543 @default.
- W2091247151 cites W2021388708 @default.
- W2091247151 cites W2024866452 @default.
- W2091247151 cites W2041639550 @default.
- W2091247151 cites W2049561326 @default.
- W2091247151 cites W205061201 @default.
- W2091247151 cites W2051414870 @default.
- W2091247151 cites W2056373381 @default.
- W2091247151 cites W2075230808 @default.
- W2091247151 cites W2081135713 @default.
- W2091247151 cites W2081582510 @default.
- W2091247151 cites W2089019735 @default.
- W2091247151 cites W2112365969 @default.
- W2091247151 cites W2131182270 @default.
- W2091247151 cites W2142207444 @default.
- W2091247151 cites W2144206181 @default.
- W2091247151 cites W2157589212 @default.
- W2091247151 cites W2158837478 @default.
- W2091247151 cites W2166858482 @default.
- W2091247151 cites W2346052124 @default.
- W2091247151 doi "https://doi.org/10.1073/pnas.85.17.6267" @default.
- W2091247151 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/281950" @default.
- W2091247151 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3166139" @default.
- W2091247151 hasPublicationYear "1988" @default.
- W2091247151 type Work @default.
- W2091247151 sameAs 2091247151 @default.
- W2091247151 citedByCount "113" @default.
- W2091247151 crossrefType "journal-article" @default.
- W2091247151 hasAuthorship W2091247151A5037088178 @default.
- W2091247151 hasAuthorship W2091247151A5062031732 @default.
- W2091247151 hasBestOaLocation W20912471511 @default.
- W2091247151 hasConcept C104317684 @default.
- W2091247151 hasConcept C111936080 @default.
- W2091247151 hasConcept C125996951 @default.
- W2091247151 hasConcept C143065580 @default.
- W2091247151 hasConcept C150194340 @default.
- W2091247151 hasConcept C153911025 @default.
- W2091247151 hasConcept C21784809 @default.
- W2091247151 hasConcept C501734568 @default.
- W2091247151 hasConcept C54355233 @default.
- W2091247151 hasConcept C86803240 @default.
- W2091247151 hasConceptScore W2091247151C104317684 @default.
- W2091247151 hasConceptScore W2091247151C111936080 @default.
- W2091247151 hasConceptScore W2091247151C125996951 @default.
- W2091247151 hasConceptScore W2091247151C143065580 @default.
- W2091247151 hasConceptScore W2091247151C150194340 @default.
- W2091247151 hasConceptScore W2091247151C153911025 @default.
- W2091247151 hasConceptScore W2091247151C21784809 @default.
- W2091247151 hasConceptScore W2091247151C501734568 @default.
- W2091247151 hasConceptScore W2091247151C54355233 @default.
- W2091247151 hasConceptScore W2091247151C86803240 @default.
- W2091247151 hasIssue "17" @default.
- W2091247151 hasLocation W20912471511 @default.
- W2091247151 hasLocation W20912471512 @default.
- W2091247151 hasLocation W20912471513 @default.
- W2091247151 hasLocation W20912471514 @default.
- W2091247151 hasOpenAccess W2091247151 @default.
- W2091247151 hasPrimaryLocation W20912471511 @default.
- W2091247151 hasRelatedWork W2010420636 @default.
- W2091247151 hasRelatedWork W2113330652 @default.
- W2091247151 hasRelatedWork W2171096629 @default.
- W2091247151 hasRelatedWork W2401460808 @default.
- W2091247151 hasRelatedWork W2567553314 @default.
- W2091247151 hasRelatedWork W2786141666 @default.
- W2091247151 hasRelatedWork W3069949010 @default.
- W2091247151 hasRelatedWork W3098554796 @default.
- W2091247151 hasRelatedWork W3119947529 @default.
- W2091247151 hasRelatedWork W978145915 @default.
- W2091247151 hasVolume "85" @default.
- W2091247151 isParatext "false" @default.
- W2091247151 isRetracted "false" @default.
- W2091247151 magId "2091247151" @default.
- W2091247151 workType "article" @default.