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- W2091249023 abstract "Intra-arterial infusions (4 micrograms min-1) of prostaglandin E2 (PGE2) were used to stimulate intestinal fluid secretion in anaesthetized rats. Morphine (0.625-40 mg kg-1) produced a dose-dependent restoration of fluid transport from secretion to the normal rate of absorption. Pretreatment with up to eight doses of morphine (20 mg kg-1) did not induce tolerance, rather it enhanced the antisecretory effect of a subsequent acute dose of morphine. It seems probable that this was caused by the accumulation of morphine in the intestine. Clonidine (4-1000 micrograms kg-1, like morphine, produced a dose-dependent reversal of stimulated fluid secretion. Pretreatment with clonidine (4 x 0.25 mg kg-1) caused a shift of the clonidine antisecretory dose-response curve to the right, demonstrating tolerance. Pretreatment with clonidine also caused cross-tolerance to the antisecretory effect of morphine. The results suggest that there is a close relationship between opioid- and alpha 2-adrenoceptors in controlling inhibition of intestinal fluid secretion." @default.
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- W2091249023 date "1991-09-01" @default.
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- W2091249023 title "Studies to determine whether there is tolerance or cross-tolerance to the antisecretory effect of morphine and clonidine in the rat intestine" @default.
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- W2091249023 doi "https://doi.org/10.1111/j.2042-7158.1991.tb03557.x" @default.
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