Matches in SemOpenAlex for { <https://semopenalex.org/work/W2091249249> ?p ?o ?g. }
- W2091249249 endingPage "39" @default.
- W2091249249 startingPage "30" @default.
- W2091249249 abstract "Lectin-functionalized, polyethylene glycol–block-poly-(d,l)-lactic-co-glycolic acid nanoparticles loaded with haloperidol were prepared with narrow size distributions and sizes <135 nm. The nanoparticles exhibited high Solanum tuberosum lectin (STL) conjugation efficiencies, encapsulation efficiencies, and drug loading capacities. The in vitro release of haloperidol was 6–8% of the loaded amount in endo-lysosomal conditions over 96 h, demonstrating minimal drug leakage and the potential for the efficient drug transport to the targeted brain tissue. The haloperidol released upon erosion was successful in displacing [3H] N-propylnorapomorphine and binding to bovine striatal dopamine D2 receptors. Both haloperidol-loaded nanoparticle formulations were found to be highly effective at inducing catalepsy. Intranasal administration of STL-functionalized nanoparticles increased the brain tissue haloperidol concentrations by 1.5–3-fold compared to non-STL-functionalized particles and other routes of administration. This formulation demonstrates promise in the reduction of the drug dose necessary to produce a therapeutic effect with antipsychotic drugs for the treatment of schizophrenia." @default.
- W2091249249 created "2016-06-24" @default.
- W2091249249 creator A5014184827 @default.
- W2091249249 creator A5029917715 @default.
- W2091249249 creator A5034451003 @default.
- W2091249249 creator A5043077080 @default.
- W2091249249 creator A5076132460 @default.
- W2091249249 creator A5079317037 @default.
- W2091249249 creator A5085785646 @default.
- W2091249249 creator A5091258730 @default.
- W2091249249 date "2014-05-01" @default.
- W2091249249 modified "2023-10-03" @default.
- W2091249249 title "Haloperidol-loaded intranasally administered lectin functionalized poly(ethylene glycol)–block-poly(d,l)-lactic-co-glycolic acid (PEG–PLGA) nanoparticles for the treatment of schizophrenia" @default.
- W2091249249 cites W1560983797 @default.
- W2091249249 cites W1775749144 @default.
- W2091249249 cites W1973544766 @default.
- W2091249249 cites W1980122435 @default.
- W2091249249 cites W1982471389 @default.
- W2091249249 cites W1982487069 @default.
- W2091249249 cites W1988652094 @default.
- W2091249249 cites W1994294415 @default.
- W2091249249 cites W1996697333 @default.
- W2091249249 cites W2001525797 @default.
- W2091249249 cites W2011953775 @default.
- W2091249249 cites W2018340655 @default.
- W2091249249 cites W2018742347 @default.
- W2091249249 cites W2021913844 @default.
- W2091249249 cites W2025348471 @default.
- W2091249249 cites W2031000084 @default.
- W2091249249 cites W2032925076 @default.
- W2091249249 cites W2033428309 @default.
- W2091249249 cites W2035745039 @default.
- W2091249249 cites W2036794860 @default.
- W2091249249 cites W2040492082 @default.
- W2091249249 cites W2041263913 @default.
- W2091249249 cites W2045246594 @default.
- W2091249249 cites W2045333343 @default.
- W2091249249 cites W2046606679 @default.
- W2091249249 cites W2046906032 @default.
- W2091249249 cites W2048006982 @default.
- W2091249249 cites W2056328574 @default.
- W2091249249 cites W2061252416 @default.
- W2091249249 cites W2063269146 @default.
- W2091249249 cites W2069073256 @default.
- W2091249249 cites W2070848488 @default.
- W2091249249 cites W2073618643 @default.
- W2091249249 cites W2075872837 @default.
- W2091249249 cites W2077613860 @default.
- W2091249249 cites W2086543436 @default.
- W2091249249 cites W2090074038 @default.
- W2091249249 cites W2092435415 @default.
- W2091249249 cites W2093918270 @default.
- W2091249249 cites W2095894333 @default.
- W2091249249 cites W2100637064 @default.
- W2091249249 cites W2101099825 @default.
- W2091249249 cites W2106314163 @default.
- W2091249249 cites W2110651692 @default.
- W2091249249 cites W2127162452 @default.
- W2091249249 cites W2136120243 @default.
- W2091249249 cites W2143629227 @default.
- W2091249249 cites W2153002415 @default.
- W2091249249 cites W2254092841 @default.
- W2091249249 doi "https://doi.org/10.1016/j.ejpb.2014.02.007" @default.
- W2091249249 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24560967" @default.
- W2091249249 hasPublicationYear "2014" @default.
- W2091249249 type Work @default.
- W2091249249 sameAs 2091249249 @default.
- W2091249249 citedByCount "69" @default.
- W2091249249 countsByYear W20912492492014 @default.
- W2091249249 countsByYear W20912492492015 @default.
- W2091249249 countsByYear W20912492492016 @default.
- W2091249249 countsByYear W20912492492017 @default.
- W2091249249 countsByYear W20912492492018 @default.
- W2091249249 countsByYear W20912492492019 @default.
- W2091249249 countsByYear W20912492492020 @default.
- W2091249249 countsByYear W20912492492021 @default.
- W2091249249 countsByYear W20912492492022 @default.
- W2091249249 countsByYear W20912492492023 @default.
- W2091249249 crossrefType "journal-article" @default.
- W2091249249 hasAuthorship W2091249249A5014184827 @default.
- W2091249249 hasAuthorship W2091249249A5029917715 @default.
- W2091249249 hasAuthorship W2091249249A5034451003 @default.
- W2091249249 hasAuthorship W2091249249A5043077080 @default.
- W2091249249 hasAuthorship W2091249249A5076132460 @default.
- W2091249249 hasAuthorship W2091249249A5079317037 @default.
- W2091249249 hasAuthorship W2091249249A5085785646 @default.
- W2091249249 hasAuthorship W2091249249A5091258730 @default.
- W2091249249 hasConcept C10138342 @default.
- W2091249249 hasConcept C134018914 @default.
- W2091249249 hasConcept C13965031 @default.
- W2091249249 hasConcept C155672457 @default.
- W2091249249 hasConcept C162324750 @default.
- W2091249249 hasConcept C171250308 @default.
- W2091249249 hasConcept C178790620 @default.
- W2091249249 hasConcept C185592680 @default.
- W2091249249 hasConcept C192562407 @default.
- W2091249249 hasConcept C202751555 @default.
- W2091249249 hasConcept C2775920511 @default.