FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2091253117> ?p ?o ?g. }

• W2091253117 endingPage "247" @default.
• W2091253117 startingPage "241" @default.
• W2091253117 abstract "Alterations in proto-oncogenes and tumor suppressor genes play a role in the sequence from Barrett's metaplasia to esophageal adenocarcinoma. The present study aims to ascertain whether molecular abnormalities take place in Barrett's metaplasia and low-grade dysplasia and to correlate them with the histological features of the esophageal mucosa. Forty-one formalin-fixed, paraffin-embedded endoscopic esophageal biopsies were classified according to the type of metaplastic changes (noncolumnar fundic and cardial metaplasia; columnar metaplasia, with and without intestinal features). After microdissection samples were examined for loss of heterozygosity (LOH) using polymorphic markers on 5q (D5S82), corresponding to APC (adenomatous polyposis coli) gene, 13q (CA repeat in intron 2 position 14815 to 14998 of the retinoblastoma gene), 17p (D17S513) corresponding to p53 locus, and for p53 mutations. Molecular alterations including LOH, allelic imbalance, and microsatellite instability could be detected in all types of metaplastic changes and sporadically in the squamous epithelium adjacent to the metaplastic tissue. Molecular alterations involving microsatellites D5S82 and the CA repeat inside the retinoblastoma gene were more frequent in nonintestinal metaplasia whereas those involving the p53 locus took place in columnar intestinal metaplasia and in low-grade dysplasia. Clonal changes were demonstrated in different metaplastic areas in three patients. Genetic alterations comprising LOH and microsatellite instability characterize Barrett's mucosa and appear related to the type of metaplastic change. Some of them precede the development of intestinal metaplasia, suggesting that genetic alterations take place earlier than previously thought." @default.
• W2091253117 created "2016-06-24" @default.
• W2091253117 creator A5006953770 @default.
• W2091253117 creator A5015547471 @default.
• W2091253117 creator A5019434935 @default.
• W2091253117 creator A5021059349 @default.
• W2091253117 creator A5041255789 @default.
• W2091253117 creator A5046399365 @default.
• W2091253117 creator A5068805507 @default.
• W2091253117 creator A5074108630 @default.
• W2091253117 creator A5090223971 @default.
• W2091253117 date "2001-02-01" @default.
• W2091253117 modified "2023-10-16" @default.
• W2091253117 title "Molecular Alterations of Barrett's Esophagus on Microdissected Endoscopic Biopsies" @default.
• W2091253117 cites W1538161738 @default.
• W2091253117 cites W155582688 @default.
• W2091253117 cites W1573413333 @default.
• W2091253117 cites W1819031394 @default.
• W2091253117 cites W1964010321 @default.
• W2091253117 cites W1986927287 @default.
• W2091253117 cites W1993243220 @default.
• W2091253117 cites W1999223967 @default.
• W2091253117 cites W2017174304 @default.
• W2091253117 cites W2032267557 @default.
• W2091253117 cites W2056034493 @default.
• W2091253117 cites W2057970447 @default.
• W2091253117 cites W2065081049 @default.
• W2091253117 cites W2066180821 @default.
• W2091253117 cites W2078604197 @default.
• W2091253117 cites W2089337970 @default.
• W2091253117 cites W2101947806 @default.
• W2091253117 cites W2104882582 @default.
• W2091253117 cites W2145497543 @default.
• W2091253117 doi "https://doi.org/10.1038/labinvest.3780232" @default.
• W2091253117 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11232646" @default.
• W2091253117 hasPublicationYear "2001" @default.
• W2091253117 type Work @default.
• W2091253117 sameAs 2091253117 @default.
• W2091253117 citedByCount "43" @default.
• W2091253117 countsByYear W20912531172012 @default.
• W2091253117 countsByYear W20912531172013 @default.
• W2091253117 countsByYear W20912531172014 @default.
• W2091253117 countsByYear W20912531172015 @default.
• W2091253117 countsByYear W20912531172016 @default.
• W2091253117 countsByYear W20912531172018 @default.
• W2091253117 countsByYear W20912531172022 @default.
• W2091253117 crossrefType "journal-article" @default.
• W2091253117 hasAuthorship W2091253117A5006953770 @default.
• W2091253117 hasAuthorship W2091253117A5015547471 @default.
• W2091253117 hasAuthorship W2091253117A5019434935 @default.
• W2091253117 hasAuthorship W2091253117A5021059349 @default.
• W2091253117 hasAuthorship W2091253117A5041255789 @default.
• W2091253117 hasAuthorship W2091253117A5046399365 @default.
• W2091253117 hasAuthorship W2091253117A5068805507 @default.
• W2091253117 hasAuthorship W2091253117A5074108630 @default.
• W2091253117 hasAuthorship W2091253117A5090223971 @default.
• W2091253117 hasBestOaLocation W20912531171 @default.
• W2091253117 hasConcept C104317684 @default.
• W2091253117 hasConcept C105702510 @default.
• W2091253117 hasConcept C11242284 @default.
• W2091253117 hasConcept C121608353 @default.
• W2091253117 hasConcept C142724271 @default.
• W2091253117 hasConcept C143589142 @default.
• W2091253117 hasConcept C180754005 @default.
• W2091253117 hasConcept C2775894508 @default.
• W2091253117 hasConcept C2776497702 @default.
• W2091253117 hasConcept C2777819096 @default.
• W2091253117 hasConcept C2778589982 @default.
• W2091253117 hasConcept C2779357193 @default.
• W2091253117 hasConcept C2779767149 @default.
• W2091253117 hasConcept C2780323790 @default.
• W2091253117 hasConcept C2780814781 @default.
• W2091253117 hasConcept C2781182431 @default.
• W2091253117 hasConcept C502942594 @default.
• W2091253117 hasConcept C526805850 @default.
• W2091253117 hasConcept C54355233 @default.
• W2091253117 hasConcept C61320498 @default.
• W2091253117 hasConcept C71924100 @default.
• W2091253117 hasConcept C86803240 @default.
• W2091253117 hasConceptScore W2091253117C104317684 @default.
• W2091253117 hasConceptScore W2091253117C105702510 @default.
• W2091253117 hasConceptScore W2091253117C11242284 @default.
• W2091253117 hasConceptScore W2091253117C121608353 @default.
• W2091253117 hasConceptScore W2091253117C142724271 @default.
• W2091253117 hasConceptScore W2091253117C143589142 @default.
• W2091253117 hasConceptScore W2091253117C180754005 @default.
• W2091253117 hasConceptScore W2091253117C2775894508 @default.
• W2091253117 hasConceptScore W2091253117C2776497702 @default.
• W2091253117 hasConceptScore W2091253117C2777819096 @default.
• W2091253117 hasConceptScore W2091253117C2778589982 @default.
• W2091253117 hasConceptScore W2091253117C2779357193 @default.
• W2091253117 hasConceptScore W2091253117C2779767149 @default.
• W2091253117 hasConceptScore W2091253117C2780323790 @default.
• W2091253117 hasConceptScore W2091253117C2780814781 @default.
• W2091253117 hasConceptScore W2091253117C2781182431 @default.
• W2091253117 hasConceptScore W2091253117C502942594 @default.
• W2091253117 hasConceptScore W2091253117C526805850 @default.
• W2091253117 hasConceptScore W2091253117C54355233 @default.

• next