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- W2091255982 abstract "Magnetic resonance imaging has tremendous potential to illuminate ischemic stroke pathophysiology and guide rational treatment decisions. Clinical applications to date have been largely limited to trials. However, recent analyses of the major clinical studies have led to refinements in selection criteria and improved understanding of the potential implications for the risk vs. benefit of thrombolytic therapy. In parallel, preclinical studies have provided complementary information on the evolution of stroke that is difficult to obtain in humans due to the requirement for continuous or repeated imaging and pathological verification. We review the clinical and preclinical advances that have led to perfusion–diffusion mismatch being applied in phase 3 randomized trials and, potentially, future routine clinical practice." @default.
- W2091255982 created "2016-06-24" @default.
- W2091255982 creator A5033743694 @default.
- W2091255982 creator A5039977865 @default.
- W2091255982 date "2013-11-11" @default.
- W2091255982 modified "2023-09-23" @default.
- W2091255982 title "Translational Perspectives on Perfusion–Diffusion Mismatch in Ischemic Stroke" @default.
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- W2091255982 doi "https://doi.org/10.1111/ijs.12186" @default.
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