FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2091256305> ?p ?o ?g. }

• W2091256305 endingPage "180" @default.
• W2091256305 startingPage "167" @default.
• W2091256305 abstract "In order to obtain information about different factors which exert a great influence on the conformational equilibria of mono-, di- and oligonucleotides, the average conformation of four heterodinucleoside monophosphates, ApC, CpA, ApU and UpA, was studied by 1H-NMR at 250 MHz and compared with that of GpC, CpG, GpU, UpG and the corresponding nucleosides and nucleotides. The ratio of NS conformers and the rotamer distribution of the exocyclic group were evaluated from proton-proton coupling constants, and the orientation of the base about the glycosidic bond from proton relaxation involving selective deuteration. The influence of intra- and intermolecular interactions on proton chemical shifts and conformational equilibria has been carefully studied from temperature and concentration effects. The results show that intermolecular base-base stacking does not modify the average conformation of dinucleoside monophosphates, while the intramolecular interaction (between residues of the same molecule) favours the N conformer, the gg rotamer and the anti conformation. The large upfield shift of H5′ (lower field resonances) compared with H5″ (higher field resonances) and the large variation of the N proportion with increasing temperature suggest that H3′ is statistically closer to H5′ than H5″. There is a correlation between temperature, the gg rotamer and the variation in the relative chemical shifts between H5′ and H5″. These conclusions are in agreement with those of our previous work on GMPs using pH and temperature effects. T1 relaxation studies indicate a large predominance of the anti conformation for both residues of ApC and ApU; these two compounds also exhibit a very high degree of association. For the naturally occurring ribonucleoside derivatives in aqueous solution, the base chemical structure, the position of the phosphate group, the temperature and pH are among the most important factors which can modify the conformation equilibria of molecules: the N conformation is generally more favoured in pyrimidine than in purine derivatives. The anti proportion is higher in 5′- than in 2′- or 3′-mononucleotides. However, the influence due to the position of the phosphate group is not determined in dinucleoside monophosphates. The temperature effect is negligible on the conformation of monomers but is remarkably large for the dimers: it consists of reducing the N and gg proportions which are preponderant in the dimers at room temperature. The pH effect is particularly large for the G residue, the conformation of which changes upon pr tonation at N7 (pK ≈ 2.3); the N conformer is favoured at acidic pH." @default.
• W2091256305 created "2016-06-24" @default.
• W2091256305 creator A5017346499 @default.
• W2091256305 creator A5061712227 @default.
• W2091256305 creator A5088938021 @default.
• W2091256305 date "1981-09-01" @default.
• W2091256305 modified "2023-10-09" @default.
• W2091256305 title "1H-NMR comparative studies of dinucleoside monophosphates. Influence of different factors on the conformational equilibria of nucleoside and dinucleoside monophosphates in aqueous solution" @default.
• W2091256305 cites W1548598852 @default.
• W2091256305 cites W1550031764 @default.
• W2091256305 cites W1613350824 @default.
• W2091256305 cites W1965390290 @default.
• W2091256305 cites W1967916013 @default.
• W2091256305 cites W1969776708 @default.
• W2091256305 cites W1973503110 @default.
• W2091256305 cites W1981365494 @default.
• W2091256305 cites W1982350866 @default.
• W2091256305 cites W1990227667 @default.
• W2091256305 cites W1996560435 @default.
• W2091256305 cites W1996788597 @default.
• W2091256305 cites W1997168295 @default.
• W2091256305 cites W1997721395 @default.
• W2091256305 cites W1998394472 @default.
• W2091256305 cites W1999046009 @default.
• W2091256305 cites W2001001471 @default.
• W2091256305 cites W2003778642 @default.
• W2091256305 cites W2004299505 @default.
• W2091256305 cites W2005727931 @default.
• W2091256305 cites W2021485125 @default.
• W2091256305 cites W2023667758 @default.
• W2091256305 cites W2023867539 @default.
• W2091256305 cites W2024805770 @default.
• W2091256305 cites W2030883058 @default.
• W2091256305 cites W2038608225 @default.
• W2091256305 cites W2042637393 @default.
• W2091256305 cites W2044536154 @default.
• W2091256305 cites W2048317733 @default.
• W2091256305 cites W2049499505 @default.
• W2091256305 cites W2052888487 @default.
• W2091256305 cites W2054954359 @default.
• W2091256305 cites W2055089945 @default.
• W2091256305 cites W2055192015 @default.
• W2091256305 cites W2058616804 @default.
• W2091256305 cites W2061822610 @default.
• W2091256305 cites W2062064507 @default.
• W2091256305 cites W2073807076 @default.
• W2091256305 cites W2077412132 @default.
• W2091256305 cites W2079630507 @default.
• W2091256305 cites W2080666876 @default.
• W2091256305 cites W2080825199 @default.
• W2091256305 cites W2082081467 @default.
• W2091256305 cites W2082161139 @default.
• W2091256305 cites W2083159453 @default.
• W2091256305 cites W2084359121 @default.
• W2091256305 cites W2089323676 @default.
• W2091256305 cites W2090703217 @default.
• W2091256305 cites W2091316326 @default.
• W2091256305 cites W2091920564 @default.
• W2091256305 cites W2095299167 @default.
• W2091256305 cites W2116965034 @default.
• W2091256305 cites W2122693467 @default.
• W2091256305 cites W4297930488 @default.
• W2091256305 doi "https://doi.org/10.1016/0005-2787(81)90006-x" @default.
• W2091256305 hasPublicationYear "1981" @default.
• W2091256305 type Work @default.
• W2091256305 sameAs 2091256305 @default.
• W2091256305 citedByCount "16" @default.
• W2091256305 countsByYear W20912563052016 @default.
• W2091256305 crossrefType "journal-article" @default.
• W2091256305 hasAuthorship W2091256305A5017346499 @default.
• W2091256305 hasAuthorship W2091256305A5061712227 @default.
• W2091256305 hasAuthorship W2091256305A5088938021 @default.
• W2091256305 hasConcept C103319777 @default.
• W2091256305 hasConcept C104317684 @default.
• W2091256305 hasConcept C111429119 @default.
• W2091256305 hasConcept C112887158 @default.
• W2091256305 hasConcept C115624301 @default.
• W2091256305 hasConcept C121332964 @default.
• W2091256305 hasConcept C147789679 @default.
• W2091256305 hasConcept C150487720 @default.
• W2091256305 hasConcept C155518411 @default.
• W2091256305 hasConcept C15744967 @default.
• W2091256305 hasConcept C166950319 @default.
• W2091256305 hasConcept C178790620 @default.
• W2091256305 hasConcept C181199279 @default.
• W2091256305 hasConcept C185592680 @default.
• W2091256305 hasConcept C18705241 @default.
• W2091256305 hasConcept C2776029896 @default.
• W2091256305 hasConcept C32909587 @default.
• W2091256305 hasConcept C33347731 @default.
• W2091256305 hasConcept C512185932 @default.
• W2091256305 hasConcept C54516573 @default.
• W2091256305 hasConcept C55493867 @default.
• W2091256305 hasConcept C62520636 @default.
• W2091256305 hasConcept C66974803 @default.
• W2091256305 hasConcept C71240020 @default.
• W2091256305 hasConcept C75079739 @default.
• W2091256305 hasConcept C77805123 @default.

• next