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- W2091258666 abstract "An optimized process for protein encapsulation was applied to formulate epidermal growth factor (rhEGF)-poly-ε-caprolactone microspheres. Microparticles mean size was 3.8 µm ± 0.2 and the encapsulation efficiency was 41.9% ± 2.6. rhEGF recovery after the encapsulation process was ∼70% (41.9% inside the microspheres and 30% still active in the external phase). In vitro release experiments in McIlvaine buffered solution showed a rhEGF sustained release over 4 days. Skin absorption studies conducted on full-thickness human skin using the Franz cell method showed that 20% rhEGF was released from the microspheres after 24 h exposure. Microspheres accumulated in the stratum corneum where they may act as a rhEGF reservoir. Therefore, rhEGF-PCL microparticles seemed to be promising systems due to their ability to provide locally a sustained release of rhEGF in skin layers." @default.
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- W2091258666 date "2010-01-01" @default.
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- W2091258666 title "rhEGF microsphere formulation andin vitroskin evaluation" @default.
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- W2091258666 doi "https://doi.org/10.3109/02652040902749061" @default.
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