Matches in SemOpenAlex for { <https://semopenalex.org/work/W2091259074> ?p ?o ?g. }
Showing items 1 to 60 of
60
with 100 items per page.
- W2091259074 endingPage "205" @default.
- W2091259074 startingPage "200" @default.
- W2091259074 abstract "Abstract. The influence of short-term exposure to LRH on the responsiveness to LRH and on the LH content of the pituitary gland was studied in the 2-weeks ovariectomized rat. Rats were infused with LRH at the rate of either 208 or 1040 ng/h from 12.00 h to 15.00 h on day 0, and injected with 3 μg of oestradiol-benzoate (OeB) or oil at 09.00 h on either day 1 or day 3. LH-responses were induced by a 21-h lasting infusion of LRH at the rate of 104 ng/h, starting at 12.00 h on the day after the OeB/oil treatment. Control rats received only one LRH treatment: they were injected with OeB or oil on day—1 and LH-responses were induced on day 0. Results were evaluated on the basis of two parameters: total amounts of LH released during exposure to LRH (1) and release efficiency, i.e. total amounts of LH released in relation to pituitary LH content (2). The findings obtained indicate that exposure to relatively low LRH concentrations causes a greater loss of release efficiency than exposure to relatively high ones. Loss of release efficiency may even increase long after the blood has been cleared of the releasing hormone. From the present experiments it can thus be inferred that exposure of the pituitary gland to LRH leads to either a marked loss of release efficiency and a relatively small LH depletion (1), or a smaller loss of release efficiency and a relatively large LH depletion (2). The two variables both influence the state of responsiveness of the pituitary gland and the present results indicate that only in situation 2 the LH-responsiveness recovers effectively. However, when after exposure to LRH rats are treated with OeB, the consequences, in terms of total amounts of LH released, of differences in degrees of loss of release efficiency and in depletion of LH are eliminated. It is suggested that during the ovulatory cycle this effect of oestrogen plays an important role in the process of recovery of the pituitary gland from diminished responsiveness to LRH induced by LRH." @default.
- W2091259074 created "2016-06-24" @default.
- W2091259074 creator A5022562836 @default.
- W2091259074 creator A5058785680 @default.
- W2091259074 creator A5058813081 @default.
- W2091259074 date "1982-02-01" @default.
- W2091259074 modified "2023-09-26" @default.
- W2091259074 title "Long-lasting desensitizing effect of short-term LRH exposure on the pituitary responsiveness to LRH in the ovariectomized rat" @default.
- W2091259074 doi "https://doi.org/10.1530/acta.0.0990200" @default.
- W2091259074 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7036629" @default.
- W2091259074 hasPublicationYear "1982" @default.
- W2091259074 type Work @default.
- W2091259074 sameAs 2091259074 @default.
- W2091259074 citedByCount "2" @default.
- W2091259074 crossrefType "journal-article" @default.
- W2091259074 hasAuthorship W2091259074A5022562836 @default.
- W2091259074 hasAuthorship W2091259074A5058785680 @default.
- W2091259074 hasAuthorship W2091259074A5058813081 @default.
- W2091259074 hasConcept C126322002 @default.
- W2091259074 hasConcept C126894567 @default.
- W2091259074 hasConcept C134018914 @default.
- W2091259074 hasConcept C138944611 @default.
- W2091259074 hasConcept C185592680 @default.
- W2091259074 hasConcept C2777658017 @default.
- W2091259074 hasConcept C71315377 @default.
- W2091259074 hasConcept C71924100 @default.
- W2091259074 hasConcept C8264082 @default.
- W2091259074 hasConcept C86803240 @default.
- W2091259074 hasConceptScore W2091259074C126322002 @default.
- W2091259074 hasConceptScore W2091259074C126894567 @default.
- W2091259074 hasConceptScore W2091259074C134018914 @default.
- W2091259074 hasConceptScore W2091259074C138944611 @default.
- W2091259074 hasConceptScore W2091259074C185592680 @default.
- W2091259074 hasConceptScore W2091259074C2777658017 @default.
- W2091259074 hasConceptScore W2091259074C71315377 @default.
- W2091259074 hasConceptScore W2091259074C71924100 @default.
- W2091259074 hasConceptScore W2091259074C8264082 @default.
- W2091259074 hasConceptScore W2091259074C86803240 @default.
- W2091259074 hasIssue "2" @default.
- W2091259074 hasLocation W20912590741 @default.
- W2091259074 hasLocation W20912590742 @default.
- W2091259074 hasOpenAccess W2091259074 @default.
- W2091259074 hasPrimaryLocation W20912590741 @default.
- W2091259074 hasRelatedWork W1981336606 @default.
- W2091259074 hasRelatedWork W1995863458 @default.
- W2091259074 hasRelatedWork W2003455196 @default.
- W2091259074 hasRelatedWork W2013119480 @default.
- W2091259074 hasRelatedWork W2059792263 @default.
- W2091259074 hasRelatedWork W2085671461 @default.
- W2091259074 hasRelatedWork W2092787895 @default.
- W2091259074 hasRelatedWork W2097476982 @default.
- W2091259074 hasRelatedWork W2146788134 @default.
- W2091259074 hasRelatedWork W2981985604 @default.
- W2091259074 hasVolume "99" @default.
- W2091259074 isParatext "false" @default.
- W2091259074 isRetracted "false" @default.
- W2091259074 magId "2091259074" @default.
- W2091259074 workType "article" @default.