FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2091259355> ?p ?o ?g. }

• W2091259355 endingPage "101" @default.
• W2091259355 startingPage "89" @default.
• W2091259355 abstract "Activated macrophages have been characterized as M1 and M2 according to their inflammatory response pattern. Here we analyzed the M2 marker expression and intracellular signal transduction in the course of cytokine-driven differentiation. We found elevated spontaneous production of the chemokines CCL17, CCL18 and CCL22 and increased expression of CD206 by alveolar macrophages from patients with lung fibrosis. Stimulation of normal human AM with Th2 cytokines IL-4 and/or IL-10 in vitro revealed IL-4 as the most powerful inducer of M2-phenotype in AM and monocytes. Importantly, IL-10 enhanced IL-4-induced expression of CCL18 and IL-1RA in a synergistic fashion. IL-4/IL-10 stimulation induces a strong activation of STAT3 in AM from fibrosis patients. These results suggest an important role for M2 polarized AM in the pathogenesis of pulmonary fibrosis and indicate that both IL-4 and IL-10 account for human AM phenotype shift to M2, as seen in patients with fibrotic interstitial lung diseases." @default.
• W2091259355 created "2016-06-24" @default.
• W2091259355 creator A5010876048 @default.
• W2091259355 creator A5012437165 @default.
• W2091259355 creator A5018617210 @default.
• W2091259355 creator A5027241081 @default.
• W2091259355 creator A5035887418 @default.
• W2091259355 creator A5051747051 @default.
• W2091259355 creator A5082032036 @default.
• W2091259355 creator A5088605736 @default.
• W2091259355 creator A5091015214 @default.
• W2091259355 date "2010-10-01" @default.
• W2091259355 modified "2023-10-18" @default.
• W2091259355 title "Alternatively activated alveolar macrophages in pulmonary fibrosis—mediator production and intracellular signal transduction" @default.
• W2091259355 cites W1606617874 @default.
• W2091259355 cites W1918921238 @default.
• W2091259355 cites W1961573346 @default.
• W2091259355 cites W1967956104 @default.
• W2091259355 cites W1968235650 @default.
• W2091259355 cites W1971463519 @default.
• W2091259355 cites W1973328836 @default.
• W2091259355 cites W1974589759 @default.
• W2091259355 cites W1974717741 @default.
• W2091259355 cites W1977843596 @default.
• W2091259355 cites W1981891281 @default.
• W2091259355 cites W1982916457 @default.
• W2091259355 cites W1983357763 @default.
• W2091259355 cites W1983962010 @default.
• W2091259355 cites W1984145560 @default.
• W2091259355 cites W1986250542 @default.
• W2091259355 cites W1995049975 @default.
• W2091259355 cites W1997500238 @default.
• W2091259355 cites W2000708019 @default.
• W2091259355 cites W2001796665 @default.
• W2091259355 cites W2003869191 @default.
• W2091259355 cites W2014737409 @default.
• W2091259355 cites W2027180323 @default.
• W2091259355 cites W2034287052 @default.
• W2091259355 cites W2037443445 @default.
• W2091259355 cites W2038689279 @default.
• W2091259355 cites W2046501504 @default.
• W2091259355 cites W2052779439 @default.
• W2091259355 cites W2063652053 @default.
• W2091259355 cites W2069035291 @default.
• W2091259355 cites W2076411129 @default.
• W2091259355 cites W2085339199 @default.
• W2091259355 cites W2090782515 @default.
• W2091259355 cites W2093705034 @default.
• W2091259355 cites W2097937633 @default.
• W2091259355 cites W2098109071 @default.
• W2091259355 cites W2105227585 @default.
• W2091259355 cites W2116000536 @default.
• W2091259355 cites W2120247510 @default.
• W2091259355 cites W2123640179 @default.
• W2091259355 cites W2128685087 @default.
• W2091259355 cites W2132430858 @default.
• W2091259355 cites W2144218612 @default.
• W2091259355 cites W2146708026 @default.
• W2091259355 cites W2161666093 @default.
• W2091259355 cites W2163702064 @default.
• W2091259355 cites W2164264453 @default.
• W2091259355 cites W2170095111 @default.
• W2091259355 cites W2171849700 @default.
• W2091259355 cites W2191654227 @default.
• W2091259355 cites W2416914730 @default.
• W2091259355 cites W4210995779 @default.
• W2091259355 doi "https://doi.org/10.1016/j.clim.2010.06.017" @default.
• W2091259355 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20674506" @default.
• W2091259355 hasPublicationYear "2010" @default.
• W2091259355 type Work @default.
• W2091259355 sameAs 2091259355 @default.
• W2091259355 citedByCount "268" @default.
• W2091259355 countsByYear W20912593552012 @default.
• W2091259355 countsByYear W20912593552013 @default.
• W2091259355 countsByYear W20912593552014 @default.
• W2091259355 countsByYear W20912593552015 @default.
• W2091259355 countsByYear W20912593552016 @default.
• W2091259355 countsByYear W20912593552017 @default.
• W2091259355 countsByYear W20912593552018 @default.
• W2091259355 countsByYear W20912593552019 @default.
• W2091259355 countsByYear W20912593552020 @default.
• W2091259355 countsByYear W20912593552021 @default.
• W2091259355 countsByYear W20912593552022 @default.
• W2091259355 countsByYear W20912593552023 @default.
• W2091259355 crossrefType "journal-article" @default.
• W2091259355 hasAuthorship W2091259355A5010876048 @default.
• W2091259355 hasAuthorship W2091259355A5012437165 @default.
• W2091259355 hasAuthorship W2091259355A5018617210 @default.
• W2091259355 hasAuthorship W2091259355A5027241081 @default.
• W2091259355 hasAuthorship W2091259355A5035887418 @default.
• W2091259355 hasAuthorship W2091259355A5051747051 @default.
• W2091259355 hasAuthorship W2091259355A5082032036 @default.
• W2091259355 hasAuthorship W2091259355A5088605736 @default.
• W2091259355 hasAuthorship W2091259355A5091015214 @default.
• W2091259355 hasConcept C126322002 @default.
• W2091259355 hasConcept C13373296 @default.
• W2091259355 hasConcept C142724271 @default.
• W2091259355 hasConcept C143172330 @default.

• next