FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2091260449> ?p ?o ?g. }

• W2091260449 endingPage "3181" @default.
• W2091260449 startingPage "3176" @default.
• W2091260449 abstract "The tuberculin skin test has been used for the diagnosis of bovine and human tuberculosis (TB) for over a hundred years. However, the specificity of the test is compromised by vaccination with the Mycobacterium bovis-derived vaccine strain bacille Calmette-Guérin (BCG). Since current promising vaccines against bovine TB are based on heterologous prime-boost combinations that include BCG, there is a need for diagnostic tests for differentiating infected from vaccinated animals (DIVA). The application of antigens such as ESAT-6 and CFP-10 for DIVA has so far been realized largely through their application in the blood-based gamma interferon release assay. In the current study, we have reassessed the potential of such antigens as skin test reagents for DIVA in cattle. A cocktail of the Mycobacterium tuberculosis complex recombinant protein antigens ESAT-6, CFP-10, MPB70, and MPB83 elicited delayed-type hypersensitivity (DTH) skin test responses in 78% of naturally infected tuberculin-positive cattle. Importantly, this cocktail induced no skin responses in BCG-vaccinated cattle despite them being sensitized for strong tuberculin responses. Further optimization of skin test antigen combinations identified that the inclusion of Rv3615c (Mb3645c) enhanced skin test sensitivity in naturally infected cattle without compromising specificity. In addition, we demonstrate for the first time the utility of synthetic peptides as promising skin test antigens for bovine TB for DIVA. Our data provide a promising basis for the future development of skin tests for DIVA with practical relevance for TB diagnosis in both veterinary and clinical settings." @default.
• W2091260449 created "2016-06-24" @default.
• W2091260449 creator A5017931416 @default.
• W2091260449 creator A5025126999 @default.
• W2091260449 creator A5050479620 @default.
• W2091260449 creator A5066741823 @default.
• W2091260449 creator A5067493731 @default.
• W2091260449 creator A5084334062 @default.
• W2091260449 creator A5091049534 @default.
• W2091260449 date "2010-09-01" @default.
• W2091260449 modified "2023-09-27" @default.
• W2091260449 title "Development of a Skin Test for Bovine Tuberculosis for Differentiating Infected from Vaccinated Animals" @default.
• W2091260449 cites W1508021298 @default.
• W2091260449 cites W1957500531 @default.
• W2091260449 cites W1966819522 @default.
• W2091260449 cites W1977475734 @default.
• W2091260449 cites W2006712363 @default.
• W2091260449 cites W2008438772 @default.
• W2091260449 cites W2044201006 @default.
• W2091260449 cites W2060491151 @default.
• W2091260449 cites W2096335875 @default.
• W2091260449 cites W2102291237 @default.
• W2091260449 cites W2106580323 @default.
• W2091260449 cites W2108723412 @default.
• W2091260449 cites W2113008350 @default.
• W2091260449 cites W2124142933 @default.
• W2091260449 cites W2127796418 @default.
• W2091260449 cites W2138647657 @default.
• W2091260449 cites W2144168219 @default.
• W2091260449 cites W2145827980 @default.
• W2091260449 cites W2154281068 @default.
• W2091260449 cites W2159022800 @default.
• W2091260449 cites W2168466885 @default.
• W2091260449 cites W2404799107 @default.
• W2091260449 cites W2413885787 @default.
• W2091260449 doi "https://doi.org/10.1128/jcm.00420-10" @default.
• W2091260449 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2937719" @default.
• W2091260449 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20592155" @default.
• W2091260449 hasPublicationYear "2010" @default.
• W2091260449 type Work @default.
• W2091260449 sameAs 2091260449 @default.
• W2091260449 citedByCount "97" @default.
• W2091260449 countsByYear W20912604492012 @default.
• W2091260449 countsByYear W20912604492013 @default.
• W2091260449 countsByYear W20912604492014 @default.
• W2091260449 countsByYear W20912604492015 @default.
• W2091260449 countsByYear W20912604492016 @default.
• W2091260449 countsByYear W20912604492017 @default.
• W2091260449 countsByYear W20912604492018 @default.
• W2091260449 countsByYear W20912604492019 @default.
• W2091260449 countsByYear W20912604492020 @default.
• W2091260449 countsByYear W20912604492021 @default.
• W2091260449 countsByYear W20912604492022 @default.
• W2091260449 countsByYear W20912604492023 @default.
• W2091260449 crossrefType "journal-article" @default.
• W2091260449 hasAuthorship W2091260449A5017931416 @default.
• W2091260449 hasAuthorship W2091260449A5025126999 @default.
• W2091260449 hasAuthorship W2091260449A5050479620 @default.
• W2091260449 hasAuthorship W2091260449A5066741823 @default.
• W2091260449 hasAuthorship W2091260449A5067493731 @default.
• W2091260449 hasAuthorship W2091260449A5084334062 @default.
• W2091260449 hasAuthorship W2091260449A5091049534 @default.
• W2091260449 hasBestOaLocation W20912604491 @default.
• W2091260449 hasConcept C142724271 @default.
• W2091260449 hasConcept C147483822 @default.
• W2091260449 hasConcept C159047783 @default.
• W2091260449 hasConcept C203014093 @default.
• W2091260449 hasConcept C22070199 @default.
• W2091260449 hasConcept C2776247216 @default.
• W2091260449 hasConcept C2777975735 @default.
• W2091260449 hasConcept C2778497218 @default.
• W2091260449 hasConcept C2781064340 @default.
• W2091260449 hasConcept C2781069245 @default.
• W2091260449 hasConcept C2781092335 @default.
• W2091260449 hasConcept C71924100 @default.
• W2091260449 hasConcept C86803240 @default.
• W2091260449 hasConceptScore W2091260449C142724271 @default.
• W2091260449 hasConceptScore W2091260449C147483822 @default.
• W2091260449 hasConceptScore W2091260449C159047783 @default.
• W2091260449 hasConceptScore W2091260449C203014093 @default.
• W2091260449 hasConceptScore W2091260449C22070199 @default.
• W2091260449 hasConceptScore W2091260449C2776247216 @default.
• W2091260449 hasConceptScore W2091260449C2777975735 @default.
• W2091260449 hasConceptScore W2091260449C2778497218 @default.
• W2091260449 hasConceptScore W2091260449C2781064340 @default.
• W2091260449 hasConceptScore W2091260449C2781069245 @default.
• W2091260449 hasConceptScore W2091260449C2781092335 @default.
• W2091260449 hasConceptScore W2091260449C71924100 @default.
• W2091260449 hasConceptScore W2091260449C86803240 @default.
• W2091260449 hasIssue "9" @default.
• W2091260449 hasLocation W20912604491 @default.
• W2091260449 hasLocation W20912604492 @default.
• W2091260449 hasLocation W20912604493 @default.
• W2091260449 hasLocation W20912604494 @default.
• W2091260449 hasOpenAccess W2091260449 @default.
• W2091260449 hasPrimaryLocation W20912604491 @default.
• W2091260449 hasRelatedWork W1969822700 @default.
• W2091260449 hasRelatedWork W2063502893 @default.

• next