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• W2091260721 abstract "Somites form by an iterative process from unsegmented, presomitic mesoderm (PSM). Notch pathway components, such as deltaC (dlc) have been shown to play a role in this process, while the T-box transcription factors Ntla and Tbx16 regulate somite formation upstream of this by controlling supply and movement of cells into the PSM during gastrulation and tailbud outgrowth. In this work, we report that Ntla and Tbx16 play a more explicit role in segmentation by directly regulating dlc expression. In addition we describe a cis-regulatory module (CRM) upstream of dlc that drives expression of a reporter in the tailbud, PSM and somites during somitogenesis. This CRM is bound by both Ntla and Tbx16 at a cluster of T-box binding sites, which are required in combination for activation of the CRM." @default.
• W2091260721 created "2016-06-24" @default.
• W2091260721 creator A5026318278 @default.
• W2091260721 creator A5060549545 @default.
• W2091260721 creator A5071423784 @default.
• W2091260721 date "2012-11-01" @default.
• W2091260721 modified "2023-09-25" @default.
• W2091260721 title "A cis-regulatory module upstream of deltaC regulated by Ntla and Tbx16 drives expression in the tailbud, presomitic mesoderm and somites" @default.
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• W2091260721 doi "https://doi.org/10.1016/j.ydbio.2012.07.002" @default.
• W2091260721 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3460241" @default.
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