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- W2091260936 abstract "Mitochondria are key organelles in eukaryotic cells principally responsible for multiple cellular functions. In addition to a plethora of somatic mutations as well as polymorphic sequence variations in mitochondrial DNA (mtDNA), the identification of increased or reduced mtDNA copy number has been increasingly reported in a broad range of primary human cancers, underscoring that accumulation of mtDNA content alterations may be a pivotal factor in eliciting persistent mitochondrial deficient activities and eventually contributing to cancer pathogenesis and progression. However, the detailed roles of altered mtDNA amount in driving the tumorigenic process remain largely unknown. This review outlines mtDNA content changes present in various types of common human malignancies and briefly describes the possible causes and their potential connections to the carcinogenic process. The present state of our knowledge regarding how altered mtDNA quantitative levels could be utilized as a diagnostic biomarker for identifying genetically predisposed population that should undergo intensive screening and early surveillance program is also discussed. Taken together, these findings strongly indicate that mtDNA copy number alterations may exert a crucial role in the pathogenic mechanisms of tumor development. Continued insights into the functional significance of altered mtDNA quantities in the etiology of human cancers will hopefully help in establishing novel potential targets for anti-tumor drugs and intervention therapies." @default.
- W2091260936 created "2016-06-24" @default.
- W2091260936 creator A5013345797 @default.
- W2091260936 date "2011-07-01" @default.
- W2091260936 modified "2023-10-14" @default.
- W2091260936 title "Generation, function and diagnostic value of mitochondrial DNA copy number alterations in human cancers" @default.
- W2091260936 cites W1547611008 @default.
- W2091260936 cites W1774344187 @default.
- W2091260936 cites W1964135779 @default.
- W2091260936 cites W1967384166 @default.
- W2091260936 cites W1977583351 @default.
- W2091260936 cites W1979610420 @default.
- W2091260936 cites W1982503419 @default.
- W2091260936 cites W1982896986 @default.
- W2091260936 cites W1984808365 @default.
- W2091260936 cites W1985929809 @default.
- W2091260936 cites W1987396916 @default.
- W2091260936 cites W1988027564 @default.
- W2091260936 cites W1988258840 @default.
- W2091260936 cites W1990321698 @default.
- W2091260936 cites W1998091937 @default.
- W2091260936 cites W2000289869 @default.
- W2091260936 cites W2004817325 @default.
- W2091260936 cites W2005901733 @default.
- W2091260936 cites W2008060326 @default.
- W2091260936 cites W2012733189 @default.
- W2091260936 cites W2013032389 @default.
- W2091260936 cites W2014793391 @default.
- W2091260936 cites W2015536907 @default.
- W2091260936 cites W2019805102 @default.
- W2091260936 cites W2022369816 @default.
- W2091260936 cites W2022807342 @default.
- W2091260936 cites W2024235550 @default.
- W2091260936 cites W2027539623 @default.
- W2091260936 cites W2027539690 @default.
- W2091260936 cites W2032811482 @default.
- W2091260936 cites W2044290038 @default.
- W2091260936 cites W2046191681 @default.
- W2091260936 cites W2051433952 @default.
- W2091260936 cites W2063093063 @default.
- W2091260936 cites W2064879869 @default.
- W2091260936 cites W2066077760 @default.
- W2091260936 cites W2066939977 @default.
- W2091260936 cites W2068671939 @default.
- W2091260936 cites W2076316408 @default.
- W2091260936 cites W2076328610 @default.
- W2091260936 cites W2076618644 @default.
- W2091260936 cites W2076693703 @default.
- W2091260936 cites W2077463956 @default.
- W2091260936 cites W2077798840 @default.
- W2091260936 cites W2079033189 @default.
- W2091260936 cites W2081532552 @default.
- W2091260936 cites W2087434357 @default.
- W2091260936 cites W2088053459 @default.
- W2091260936 cites W2088502014 @default.
- W2091260936 cites W2089393514 @default.
- W2091260936 cites W2098156737 @default.
- W2091260936 cites W2114705235 @default.
- W2091260936 cites W2120342795 @default.
- W2091260936 cites W2126763338 @default.
- W2091260936 cites W2126835521 @default.
- W2091260936 cites W2128919887 @default.
- W2091260936 cites W2135185370 @default.
- W2091260936 cites W2135365094 @default.
- W2091260936 cites W2138316044 @default.
- W2091260936 cites W2138996068 @default.
- W2091260936 cites W2139097051 @default.
- W2091260936 cites W2147875287 @default.
- W2091260936 cites W2148080180 @default.
- W2091260936 cites W2154975336 @default.
- W2091260936 cites W2164705235 @default.
- W2091260936 cites W2171143590 @default.
- W2091260936 cites W2321075098 @default.
- W2091260936 cites W2326949580 @default.
- W2091260936 cites W2332095467 @default.
- W2091260936 cites W4236306046 @default.
- W2091260936 cites W4236681524 @default.
- W2091260936 cites W4254119740 @default.
- W2091260936 cites W4362172418 @default.
- W2091260936 doi "https://doi.org/10.1016/j.lfs.2011.05.010" @default.
- W2091260936 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21683715" @default.
- W2091260936 hasPublicationYear "2011" @default.
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