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• W2091263125 endingPage "1533" @default.
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• W2091263125 abstract "The macrocyclic polyamine 2,5,8,11,14-pentaaza[15]-[15](2,9)[1,10]phenanthrolinophane (neotetren) is studied in its ability to coordinate Cu(II) even at very low pH values and to interact, as a metal complex, with DNA. The kinetics and equilibria for 1 : 1 and 2 : 1 metal–ligand complexes formation are studied by the stopped-flow method and UV spectrophotometry. Differently protonated complexes are formed, with rate constants much lower than that of water exchange at copper(II) and other Cu(II)/amine systems, this behaviour being ascribed to ring effects and intra-molecular hydrogen bonds. Concerning the DNA/copper(II)–neotetren complexes interaction, analysis of data suggests an intercalative mode of binding. The kinetic results for both DNA/CuL and DNA/Cu2L systems agree with the sequence D + S ⇄ D,S ⇄ DS where the metal complexes (D) react with the DNA sites (S) leading to fast formation of an externally bound form (D,S) which is converted into an intercalated complex (DS). A very slow process is also detected and ascribed to a conformational change in the polynucleotide secondary structure where the metal centre plays a crucial role. Chromatographic experiments demonstrate that both the investigated Cu(II)/L complexes are able to cleave DNA, but only in the presence of hydrogen peroxide." @default.
• W2091263125 created "2016-06-24" @default.
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• W2091263125 date "2006-01-01" @default.
• W2091263125 modified "2023-10-18" @default.
• W2091263125 title "Kinetic and equilibrium studies on the polyazamacrocycle neotetren: metal–complex formation and DNA interaction" @default.
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• W2091263125 doi "https://doi.org/10.1039/b512820j" @default.
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