FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2091263231> ?p ?o ?g. }

• W2091263231 endingPage "e28504" @default.
• W2091263231 startingPage "e28504" @default.
• W2091263231 abstract "In severe asthma, bronchodilator- and steroid-insensitive airflow obstruction develops through unknown mechanisms characterized by increased lung airway smooth muscle (ASM) mass and stiffness. We explored the role of a Regulator of G-protein Signaling protein (RGS4) in the ASM hyperplasia and reduced contractile capacity characteristic of advanced asthma. Using immunocytochemical staining, ASM expression of RGS4 was determined in endobronchial biopsies from healthy subjects and those from subjects with mild, moderate and severe asthma. Cell proliferation assays, agonist-induced calcium mobilization and bronchoconstriction were determined in cultured human ASM cells and in human precision cut lung slices. Using gain- and loss-of-function approaches, the precise role of RGS proteins was determined in stimulating human ASM proliferation and inhibiting bronchoconstriction. RGS4 expression was restricted to a subpopulation of ASM and was specifically upregulated by mitogens, which induced a hyperproliferative and hypocontractile ASM phenotype similar to that observed in recalcitrant asthma. RGS4 expression was markedly increased in bronchial smooth muscle of patients with severe asthma, and expression correlated significantly with reduced pulmonary function. Whereas RGS4 inhibited G protein-coupled receptor (GPCR)-mediated bronchoconstriction, unexpectedly RGS4 was required for PDGF-induced proliferation and sustained activation of PI3K, a mitogenic signaling molecule that regulates ASM proliferation. These studies indicate that increased RGS4 expression promotes a phenotypic switch of ASM, evoking irreversible airway obstruction in subjects with severe asthma." @default.
• W2091263231 created "2016-06-24" @default.
• W2091263231 creator A5004382885 @default.
• W2091263231 creator A5021453632 @default.
• W2091263231 creator A5023729627 @default.
• W2091263231 creator A5048320859 @default.
• W2091263231 creator A5056621312 @default.
• W2091263231 creator A5065791417 @default.
• W2091263231 creator A5079628483 @default.
• W2091263231 creator A5082888399 @default.
• W2091263231 creator A5085550092 @default.
• W2091263231 date "2012-01-12" @default.
• W2091263231 modified "2023-10-01" @default.
• W2091263231 title "An RGS4-Mediated Phenotypic Switch of Bronchial Smooth Muscle Cells Promotes Fixed Airway Obstruction in Asthma" @default.
• W2091263231 cites W1912592877 @default.
• W2091263231 cites W1945199177 @default.
• W2091263231 cites W1970729674 @default.
• W2091263231 cites W1987510108 @default.
• W2091263231 cites W1988124754 @default.
• W2091263231 cites W1989920655 @default.
• W2091263231 cites W1991886932 @default.
• W2091263231 cites W1993997407 @default.
• W2091263231 cites W1999578425 @default.
• W2091263231 cites W2000875765 @default.
• W2091263231 cites W2006174105 @default.
• W2091263231 cites W2009886463 @default.
• W2091263231 cites W2018421011 @default.
• W2091263231 cites W2018843539 @default.
• W2091263231 cites W2026394050 @default.
• W2091263231 cites W2037513412 @default.
• W2091263231 cites W2039252747 @default.
• W2091263231 cites W2044361144 @default.
• W2091263231 cites W2045442557 @default.
• W2091263231 cites W2055544800 @default.
• W2091263231 cites W2055771788 @default.
• W2091263231 cites W2057370954 @default.
• W2091263231 cites W2058562094 @default.
• W2091263231 cites W2062875181 @default.
• W2091263231 cites W2071831667 @default.
• W2091263231 cites W2074118676 @default.
• W2091263231 cites W2074480304 @default.
• W2091263231 cites W2077167095 @default.
• W2091263231 cites W2094714142 @default.
• W2091263231 cites W2102777513 @default.
• W2091263231 cites W2110322730 @default.
• W2091263231 cites W2127219942 @default.
• W2091263231 cites W2155255236 @default.
• W2091263231 cites W2155364072 @default.
• W2091263231 cites W2156005120 @default.
• W2091263231 cites W2160941421 @default.
• W2091263231 cites W2165879452 @default.
• W2091263231 cites W2168642008 @default.
• W2091263231 cites W2956481022 @default.
• W2091263231 doi "https://doi.org/10.1371/journal.pone.0028504" @default.
• W2091263231 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3257220" @default.
• W2091263231 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22253691" @default.
• W2091263231 hasPublicationYear "2012" @default.
• W2091263231 type Work @default.
• W2091263231 sameAs 2091263231 @default.
• W2091263231 citedByCount "30" @default.
• W2091263231 countsByYear W20912632312012 @default.
• W2091263231 countsByYear W20912632312013 @default.
• W2091263231 countsByYear W20912632312014 @default.
• W2091263231 countsByYear W20912632312015 @default.
• W2091263231 countsByYear W20912632312016 @default.
• W2091263231 countsByYear W20912632312017 @default.
• W2091263231 countsByYear W20912632312018 @default.
• W2091263231 countsByYear W20912632312019 @default.
• W2091263231 countsByYear W20912632312020 @default.
• W2091263231 countsByYear W20912632312021 @default.
• W2091263231 countsByYear W20912632312022 @default.
• W2091263231 crossrefType "journal-article" @default.
• W2091263231 hasAuthorship W2091263231A5004382885 @default.
• W2091263231 hasAuthorship W2091263231A5021453632 @default.
• W2091263231 hasAuthorship W2091263231A5023729627 @default.
• W2091263231 hasAuthorship W2091263231A5048320859 @default.
• W2091263231 hasAuthorship W2091263231A5056621312 @default.
• W2091263231 hasAuthorship W2091263231A5065791417 @default.
• W2091263231 hasAuthorship W2091263231A5079628483 @default.
• W2091263231 hasAuthorship W2091263231A5082888399 @default.
• W2091263231 hasAuthorship W2091263231A5085550092 @default.
• W2091263231 hasBestOaLocation W20912632311 @default.
• W2091263231 hasConcept C104317684 @default.
• W2091263231 hasConcept C126322002 @default.
• W2091263231 hasConcept C127561419 @default.
• W2091263231 hasConcept C134018914 @default.
• W2091263231 hasConcept C203014093 @default.
• W2091263231 hasConcept C2776042228 @default.
• W2091263231 hasConcept C2780769369 @default.
• W2091263231 hasConcept C55493867 @default.
• W2091263231 hasConcept C62478195 @default.
• W2091263231 hasConcept C71924100 @default.
• W2091263231 hasConcept C86803240 @default.
• W2091263231 hasConcept C95444343 @default.
• W2091263231 hasConceptScore W2091263231C104317684 @default.
• W2091263231 hasConceptScore W2091263231C126322002 @default.
• W2091263231 hasConceptScore W2091263231C127561419 @default.
• W2091263231 hasConceptScore W2091263231C134018914 @default.

• next