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• W2091268691 endingPage "565" @default.
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• W2091268691 abstract "Abstract T cells freshly isolated from the peripheral lymph nodes of autoimmune MRL lpr/lpr (lpr) mice contain a large proportion of functionally non‐mature T cell receptor (TcR)‐αβ + CD3 + CD2 − CD4 − CD8 − T cells displaying the B cell isoform of CD45, B220. These cells are hyporesponsive as defined by minimal interleukin‐2 (IL‐2) production and proliferation in response to stimulation. However, increased levels of inositol phosphates and a rapid mobilization of Ca 2+ do occur upon stimulation of the TcR/CD3 complex. Furthermore, lpr CD4 − CD8 − T cells contain high levels of transcripts for the src‐family tyrosine kinase p59 fyn , and express a constitutively tyrosine‐phosphorylated CD3‐ζ chain. These features bear a certain resemblance to anergized T cells. These similarities are extended to show that culturing of lpr CD4 − CD8 − T cells in the presence of IL‐2 in combination with phorbol 12‐myristate 13‐acetate and ionomycin initiates cell cycling and results in the gain of function; re‐stimulation now yields IL‐2‐dependent proliferation in the absence of exogenous IL‐2. In parallel with this gain in function, the population of cells obtained after 1 week in culture retains the TcR‐αβ + CD4 − CD8 − phenotype, yet displays increased levels of CD2, decreased surface B220, and normal amounts of p59 fyn ‐specific transcripts. These findings show that cell cycling is associated with the recovery of functional capabilities by lpr CD4 − CD8 − T cells and is closely allied with surface CD2 expression. Thus, the hyporesponsiveness of lpr T cells is not a fixed state." @default.
• W2091268691 created "2016-06-24" @default.
• W2091268691 creator A5035542584 @default.
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• W2091268691 date "1994-03-01" @default.
• W2091268691 modified "2023-09-27" @default.
• W2091268691 title "Reversal of hyporesponsiveness inlpr CD4−CD8− T cells is achieved by induction of cell cycling and normalization of CD2 and p59fyn expression" @default.
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• W2091268691 doi "https://doi.org/10.1002/eji.1830240310" @default.
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• W2091268691 hasPublicationYear "1994" @default.
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