FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2091269706> ?p ?o ?g. }

• W2091269706 endingPage "1497" @default.
• W2091269706 startingPage "1492" @default.
• W2091269706 abstract "Hepatitis B virus (HBV) infection is a major public health problem by affecting 350 million people worldwide. The mechanisms that regulate HBV gene expression and viral replication remain poorly understood. HBx is known as the central regulator for HBV replication and is associated with the CUL4-DDB1 ubiquitin ligase through H-box motif. Here, we show that blocking the activity of DDB1 by RNA interfering inhibited viral production and gene expression of HBV, and direct association of HBx with DDB1 promoted viral activities, indicating that DDB1 function is required for viral production. On the other hand, HBx interfered with DDB1-dependent polyubiquitination of PRMT1, arginine methyltransferase 1, suggesting that HBx can also block the function of a subset of CUL4-DDB1 E3 ligases. Thus, we conclude that HBx regulates the function of DDB1 in both positive and negative manners in the context of distinct CUL4-DDB1 complexes and plays different roles in HBV replication cycle." @default.
• W2091269706 created "2016-06-24" @default.
• W2091269706 creator A5010176958 @default.
• W2091269706 creator A5013758739 @default.
• W2091269706 creator A5025818509 @default.
• W2091269706 creator A5031995365 @default.
• W2091269706 creator A5037213013 @default.
• W2091269706 creator A5037990784 @default.
• W2091269706 creator A5038520234 @default.
• W2091269706 creator A5047614788 @default.
• W2091269706 creator A5047791773 @default.
• W2091269706 creator A5050193567 @default.
• W2091269706 creator A5060625131 @default.
• W2091269706 creator A5070698988 @default.
• W2091269706 creator A5072453212 @default.
• W2091269706 date "2014-08-01" @default.
• W2091269706 modified "2023-10-17" @default.
• W2091269706 title "HBx affects CUL4–DDB1 function in both positive and negative manners" @default.
• W2091269706 cites W1525178335 @default.
• W2091269706 cites W1651425720 @default.
• W2091269706 cites W1982855701 @default.
• W2091269706 cites W1985585046 @default.
• W2091269706 cites W1987051472 @default.
• W2091269706 cites W2015763479 @default.
• W2091269706 cites W2020155059 @default.
• W2091269706 cites W2032735361 @default.
• W2091269706 cites W2034626290 @default.
• W2091269706 cites W2035920453 @default.
• W2091269706 cites W2044715640 @default.
• W2091269706 cites W2056399135 @default.
• W2091269706 cites W2061505027 @default.
• W2091269706 cites W2069841786 @default.
• W2091269706 cites W2073334433 @default.
• W2091269706 cites W2074134609 @default.
• W2091269706 cites W2075325266 @default.
• W2091269706 cites W2082701826 @default.
• W2091269706 cites W2095934571 @default.
• W2091269706 cites W2147084784 @default.
• W2091269706 cites W2164322519 @default.
• W2091269706 cites W2170324534 @default.
• W2091269706 cites W2332269749 @default.
• W2091269706 cites W2774864460 @default.
• W2091269706 doi "https://doi.org/10.1016/j.bbrc.2014.07.019" @default.
• W2091269706 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25019988" @default.
• W2091269706 hasPublicationYear "2014" @default.
• W2091269706 type Work @default.
• W2091269706 sameAs 2091269706 @default.
• W2091269706 citedByCount "16" @default.
• W2091269706 countsByYear W20912697062015 @default.
• W2091269706 countsByYear W20912697062016 @default.
• W2091269706 countsByYear W20912697062017 @default.
• W2091269706 countsByYear W20912697062018 @default.
• W2091269706 countsByYear W20912697062019 @default.
• W2091269706 countsByYear W20912697062020 @default.
• W2091269706 countsByYear W20912697062021 @default.
• W2091269706 countsByYear W20912697062022 @default.
• W2091269706 countsByYear W20912697062023 @default.
• W2091269706 crossrefType "journal-article" @default.
• W2091269706 hasAuthorship W2091269706A5010176958 @default.
• W2091269706 hasAuthorship W2091269706A5013758739 @default.
• W2091269706 hasAuthorship W2091269706A5025818509 @default.
• W2091269706 hasAuthorship W2091269706A5031995365 @default.
• W2091269706 hasAuthorship W2091269706A5037213013 @default.
• W2091269706 hasAuthorship W2091269706A5037990784 @default.
• W2091269706 hasAuthorship W2091269706A5038520234 @default.
• W2091269706 hasAuthorship W2091269706A5047614788 @default.
• W2091269706 hasAuthorship W2091269706A5047791773 @default.
• W2091269706 hasAuthorship W2091269706A5050193567 @default.
• W2091269706 hasAuthorship W2091269706A5060625131 @default.
• W2091269706 hasAuthorship W2091269706A5070698988 @default.
• W2091269706 hasAuthorship W2091269706A5072453212 @default.
• W2091269706 hasConcept C104317684 @default.
• W2091269706 hasConcept C134459356 @default.
• W2091269706 hasConcept C140248907 @default.
• W2091269706 hasConcept C25602115 @default.
• W2091269706 hasConcept C54009773 @default.
• W2091269706 hasConcept C54355233 @default.
• W2091269706 hasConcept C67567795 @default.
• W2091269706 hasConcept C86803240 @default.
• W2091269706 hasConceptScore W2091269706C104317684 @default.
• W2091269706 hasConceptScore W2091269706C134459356 @default.
• W2091269706 hasConceptScore W2091269706C140248907 @default.
• W2091269706 hasConceptScore W2091269706C25602115 @default.
• W2091269706 hasConceptScore W2091269706C54009773 @default.
• W2091269706 hasConceptScore W2091269706C54355233 @default.
• W2091269706 hasConceptScore W2091269706C67567795 @default.
• W2091269706 hasConceptScore W2091269706C86803240 @default.
• W2091269706 hasFunder F4320321001 @default.
• W2091269706 hasFunder F4320322922 @default.
• W2091269706 hasFunder F4320326670 @default.
• W2091269706 hasIssue "4" @default.
• W2091269706 hasLocation W20912697061 @default.
• W2091269706 hasLocation W20912697062 @default.
• W2091269706 hasOpenAccess W2091269706 @default.
• W2091269706 hasPrimaryLocation W20912697061 @default.
• W2091269706 hasRelatedWork W1966031852 @default.
• W2091269706 hasRelatedWork W2064593517 @default.
• W2091269706 hasRelatedWork W2088542873 @default.

• next