FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2091270249> ?p ?o ?g. }

• W2091270249 endingPage "569" @default.
• W2091270249 startingPage "569" @default.
• W2091270249 abstract "HIV-1 expresses a multifunctional protein called TAT (trans-acting transcriptional activator), the function of which in vivo is tightly correlated with the incidence of Kaposi's sarcoma in AIDS patients. TAT is angiogenic and apparently binds to receptors specific for vascular endothelial growth factor (VEGF). Amino acids 46-60 of HIV-TAT, known as the basic peptide, have been shown to be responsible for its functional interaction with VEGF receptors. To characterize further the binding properties of this peptide, its coding sequence was fused to the reading frame of bacterial thioredoxin, allowing the production of large amounts of chimaeric polypeptides in bacteria in a biologically active form. Binding of chimaeric proteins to VEGF receptors was studied in vitro in endothelial cell cultures expressing either of the two receptors. Chimaeric thioredoxin proteins carrying the basic domain of TAT bound to both VEGF receptors with affinities similar to those of HIV-TAT or VEGF. Interestingly, these polypeptides competed only partially with VEGF for receptor binding, implying different binding sites for the TAT peptide and VEGF. This suggests that TAT binds VEGF receptors at new sites that might be useful targets for pharmacological intervention during pathological angiogenesis. The thioredoxin/basic-peptide chimaeras are functional agonists that mediate VEGF receptor signalling: (1) they stimulate the growth of endothelial cells; (2) together with basic fibroblast growth factor they cause tube formation of endothelial cells in collagen gels; (3) they induce blood vessel formation on the chicken chorioallantoic membrane; and (4) they activate VEGF receptor kinase and mitogen-activated protein kinase activity." @default.
• W2091270249 created "2016-06-24" @default.
• W2091270249 creator A5010874845 @default.
• W2091270249 creator A5015115550 @default.
• W2091270249 creator A5017798856 @default.
• W2091270249 creator A5022959266 @default.
• W2091270249 creator A5023859224 @default.
• W2091270249 creator A5049419554 @default.
• W2091270249 creator A5079023364 @default.
• W2091270249 creator A5079907773 @default.
• W2091270249 date "2001-02-01" @default.
• W2091270249 modified "2023-09-27" @default.
• W2091270249 title "Signalling properties of an HIV-encoded angiogenic peptide mimicking vascular endothelial growth factor activity" @default.
• W2091270249 cites W1519808760 @default.
• W2091270249 cites W1523189699 @default.
• W2091270249 cites W1564446710 @default.
• W2091270249 cites W1566059459 @default.
• W2091270249 cites W1567318029 @default.
• W2091270249 cites W1583699618 @default.
• W2091270249 cites W172183759 @default.
• W2091270249 cites W1740440689 @default.
• W2091270249 cites W1967698763 @default.
• W2091270249 cites W1975173778 @default.
• W2091270249 cites W1980969801 @default.
• W2091270249 cites W1986559037 @default.
• W2091270249 cites W1988655450 @default.
• W2091270249 cites W1988688040 @default.
• W2091270249 cites W1991463736 @default.
• W2091270249 cites W1994014733 @default.
• W2091270249 cites W1997254182 @default.
• W2091270249 cites W1998421163 @default.
• W2091270249 cites W2005192805 @default.
• W2091270249 cites W2011403734 @default.
• W2091270249 cites W2012390831 @default.
• W2091270249 cites W2020908945 @default.
• W2091270249 cites W2028825060 @default.
• W2091270249 cites W2036751011 @default.
• W2091270249 cites W2037286214 @default.
• W2091270249 cites W2037548392 @default.
• W2091270249 cites W2042143995 @default.
• W2091270249 cites W2045247659 @default.
• W2091270249 cites W2046516822 @default.
• W2091270249 cites W2047408781 @default.
• W2091270249 cites W2048185125 @default.
• W2091270249 cites W2049506650 @default.
• W2091270249 cites W2055299311 @default.
• W2091270249 cites W2057973294 @default.
• W2091270249 cites W2066407369 @default.
• W2091270249 cites W2078083828 @default.
• W2091270249 cites W2084768201 @default.
• W2091270249 cites W2092222240 @default.
• W2091270249 cites W2093498435 @default.
• W2091270249 cites W2103530688 @default.
• W2091270249 cites W2138012613 @default.
• W2091270249 cites W2138519685 @default.
• W2091270249 cites W2158566329 @default.
• W2091270249 cites W2158965678 @default.
• W2091270249 cites W2166156136 @default.
• W2091270249 cites W2395742536 @default.
• W2091270249 cites W2410104673 @default.
• W2091270249 cites W2413178119 @default.
• W2091270249 cites W344266619 @default.
• W2091270249 cites W4290247175 @default.
• W2091270249 cites W92307352 @default.
• W2091270249 doi "https://doi.org/10.1042/0264-6021:3530569" @default.
• W2091270249 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1221603" @default.
• W2091270249 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11171054" @default.
• W2091270249 hasPublicationYear "2001" @default.
• W2091270249 type Work @default.
• W2091270249 sameAs 2091270249 @default.
• W2091270249 citedByCount "20" @default.
• W2091270249 countsByYear W20912702492012 @default.
• W2091270249 countsByYear W20912702492014 @default.
• W2091270249 countsByYear W20912702492015 @default.
• W2091270249 countsByYear W20912702492017 @default.
• W2091270249 countsByYear W20912702492018 @default.
• W2091270249 countsByYear W20912702492020 @default.
• W2091270249 countsByYear W20912702492022 @default.
• W2091270249 crossrefType "journal-article" @default.
• W2091270249 hasAuthorship W2091270249A5010874845 @default.
• W2091270249 hasAuthorship W2091270249A5015115550 @default.
• W2091270249 hasAuthorship W2091270249A5017798856 @default.
• W2091270249 hasAuthorship W2091270249A5022959266 @default.
• W2091270249 hasAuthorship W2091270249A5023859224 @default.
• W2091270249 hasAuthorship W2091270249A5049419554 @default.
• W2091270249 hasAuthorship W2091270249A5079023364 @default.
• W2091270249 hasAuthorship W2091270249A5079907773 @default.
• W2091270249 hasBestOaLocation W20912702492 @default.
• W2091270249 hasConcept C146285616 @default.
• W2091270249 hasConcept C153911025 @default.
• W2091270249 hasConcept C167734588 @default.
• W2091270249 hasConcept C170493617 @default.
• W2091270249 hasConcept C2777025900 @default.
• W2091270249 hasConcept C2780394083 @default.
• W2091270249 hasConcept C502942594 @default.
• W2091270249 hasConcept C55493867 @default.
• W2091270249 hasConcept C86803240 @default.
• W2091270249 hasConcept C95444343 @default.

• next