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- W2091270791 abstract "The estrous cycles of guinea pigs were significantly (p less than .001) lenghtened by about 3 days when the animals were given sc injections of 10 mg indomethacin twice daily from Day 7 of the estrous cycle. When indomethacin was administered via a slow-release preparation placed in each uterine horn (33 mg per horn), the cycle lengths of the guinea pigs were greatly prolonged and approached that produced by hysterectomy (51-75 days). Functional corpora lutea were present in guinea pigs autopsied on Day 47 of the extended cycle and it was thus concluded that indomethacin had lengthened the estrous cycle by prolonging the life span of the corpus luteum. It was suggested that indomethacin probably inhibited the biosynthesis and release of F2alpha, a prostaglandin which is normally released from the uterus on Day 15 and which is responsible for corporal luteal regression and subsequent termination of the estrous cycle. These data give evidence that F2alpha is the uterine luteolytic hormone in guinea pigs." @default.
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- W2091270791 date "1973-09-01" @default.
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- W2091270791 title "Elongation of oestrous cycle in the guinea-pig following subcutaneous or intra-uterine administration of indomethacin" @default.
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- W2091270791 doi "https://doi.org/10.1111/j.1476-5381.1973.tb08271.x" @default.
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