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• W2091272504 abstract "JO N 3 02 3 A previous single-photon emission computed tomography (SPECT) study demonstrated striatal dopamine transporter (DAT) deficits in OT [2] but also patients with normal presynaptic nigrostriatal pathway have been reported [3]. OT has been suggested to arise from a central oscillator involving the brainstem or cerebellum [4–7]. Interestingly, neuropathological changes in essential tremor have also been found in brainstem and cerebellar structures [8]. An association between the severity of parkinsonian rest tremor and the reduction of serotonin receptor (5-HT1A) binding potential in the midbrain raphe has been shown in a positron emission tomography (PET) study which might indicate a role of the serotonergic system in the generation of tremor [9, 10]. Although imaging of presynaptic pathways by measuring the serotonin transporter (SERT) availability has been performed in different neuropsychiatric disorders including Parkinson’s disease [11, 12] where in advanced patients a regionally widespread loss of brain serotonergic innervation was found [13], studies of the serotonergic system in OT do not exist. Here, we report for the first time two cases of OT with normal SERT availability and intact nigrostriatal dopaminergic pathways suggesting a normal function of these monaminergic neurotransmitter systems. Two patients (A: 61 years, male, B: 61 years, female) presented to our neurologic department with a 5 (A) and 10 (B) year history of progressive instability when standing. Their past medical histories were unremarkable except hypertension that was treated adequately. The family history of patient A remained uninformative, the father of patient B had suffered from Parkinson’s disease. On neurological examination both patients disFlorian Wegner Karl Strecker David Boeckler Armin Wagner Christoph Preul Donald Lobsien Osama Sabri Swen Hesse" @default.
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• W2091272504 date "2008-09-25" @default.
• W2091272504 modified "2023-09-25" @default.
• W2091272504 title "Intact serotonergic and dopaminergic systems in two cases of orthostatic tremor" @default.
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• W2091272504 doi "https://doi.org/10.1007/s00415-008-0023-7" @default.
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