FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2091274479> ?p ?o ?g. }

• W2091274479 endingPage "86" @default.
• W2091274479 startingPage "81" @default.
• W2091274479 abstract "Astragalus membranaceus is a Chinese medicinal herb and has been shown to improve hapten-induced experimental colitis. One of its major components is polysaccharides. We investigated the effect of Astragalus polysaccharides (APS) on expression of TNF-α, IL-1β and NFATc4 in a rat model of experimental colitis. The experimental colitis model was induced by TNBS. Forty five rats were divided into five groups (n = 9): Normal control group, receiving ethanol vehicle with no TNBS during induction and IP saline injection during treatment; TNBS colitis model group (TNBS + IP saline), receiving only IP saline vehicle treatment; APS low dose group (TNBS + L-APS), receiving APS 100 mg/kg; APS high dose group (TNBS + H-APS), receiving APS 200 mg/kg; and positive control group (TNBS + Dexm), receiving dexamethasone 0.3 mg/kg. The clinical features, macroscopic and microscopic scores were assessed. The expressions of TNF-α, IL-1β and NFATc4 were measured by real-time PCR and ELISA assays. Compared to normal control rats, TNBS + IP saline had significant weight loss, increased macroscopic and microscopic scores, higher disease activity index (DAI) up-regulation of TNF-α, IL-1β and NFATc4 mRNA expression and up-regulation of TNF-α and IL-1β protein expression. Compared to TNBS + IP saline, treatment with APS or dexamethasone significantly reduced DAI, partially but significantly prevented TNBS colitis-induced weight loss and improved both macroscopic and microscopic scores; high dose APS or dexamethasone significantly down-regulated TNF-α and IL-1β expressions (both mRNA and protein) and up-regulated NFATc4 mRNA and protein expression. The effect of high dose APS and dexamethasone is comparable. APS significantly improved experimental TNBS-induced colitis in rats through regulation of TNF-α, IL-1β and NFATc4 expression." @default.
• W2091274479 created "2016-06-24" @default.
• W2091274479 creator A5024467636 @default.
• W2091274479 creator A5029555464 @default.
• W2091274479 creator A5034953732 @default.
• W2091274479 creator A5044180321 @default.
• W2091274479 creator A5046958803 @default.
• W2091274479 creator A5060548792 @default.
• W2091274479 creator A5088518439 @default.
• W2091274479 date "2014-12-01" @default.
• W2091274479 modified "2023-10-16" @default.
• W2091274479 title "Effect of Astragalus polysaccharides on expression of TNF-α, IL-1β and NFATc4 in a rat model of experimental colitis" @default.
• W2091274479 cites W1523941392 @default.
• W2091274479 cites W1967949491 @default.
• W2091274479 cites W1970094743 @default.
• W2091274479 cites W1971903571 @default.
• W2091274479 cites W1976848569 @default.
• W2091274479 cites W1986372269 @default.
• W2091274479 cites W1988581085 @default.
• W2091274479 cites W2006194008 @default.
• W2091274479 cites W2006639479 @default.
• W2091274479 cites W2013093324 @default.
• W2091274479 cites W2022397126 @default.
• W2091274479 cites W2023012759 @default.
• W2091274479 cites W2023265875 @default.
• W2091274479 cites W2025065287 @default.
• W2091274479 cites W2027012270 @default.
• W2091274479 cites W2037713751 @default.
• W2091274479 cites W2054450659 @default.
• W2091274479 cites W206660799 @default.
• W2091274479 cites W2069490622 @default.
• W2091274479 cites W2078621117 @default.
• W2091274479 cites W2083262213 @default.
• W2091274479 cites W2093875188 @default.
• W2091274479 cites W2097121808 @default.
• W2091274479 cites W2099662390 @default.
• W2091274479 cites W2102764783 @default.
• W2091274479 cites W2107562936 @default.
• W2091274479 cites W2107958058 @default.
• W2091274479 cites W2110484575 @default.
• W2091274479 cites W2120862947 @default.
• W2091274479 cites W2147931681 @default.
• W2091274479 cites W2152145979 @default.
• W2091274479 cites W2160899610 @default.
• W2091274479 cites W2169501969 @default.
• W2091274479 cites W4244626580 @default.
• W2091274479 cites W61251924 @default.
• W2091274479 doi "https://doi.org/10.1016/j.cyto.2014.07.250" @default.
• W2091274479 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25132256" @default.
• W2091274479 hasPublicationYear "2014" @default.
• W2091274479 type Work @default.
• W2091274479 sameAs 2091274479 @default.
• W2091274479 citedByCount "81" @default.
• W2091274479 countsByYear W20912744792015 @default.
• W2091274479 countsByYear W20912744792016 @default.
• W2091274479 countsByYear W20912744792017 @default.
• W2091274479 countsByYear W20912744792018 @default.
• W2091274479 countsByYear W20912744792019 @default.
• W2091274479 countsByYear W20912744792020 @default.
• W2091274479 countsByYear W20912744792021 @default.
• W2091274479 countsByYear W20912744792022 @default.
• W2091274479 countsByYear W20912744792023 @default.
• W2091274479 crossrefType "journal-article" @default.
• W2091274479 hasAuthorship W2091274479A5024467636 @default.
• W2091274479 hasAuthorship W2091274479A5029555464 @default.
• W2091274479 hasAuthorship W2091274479A5034953732 @default.
• W2091274479 hasAuthorship W2091274479A5044180321 @default.
• W2091274479 hasAuthorship W2091274479A5046958803 @default.
• W2091274479 hasAuthorship W2091274479A5060548792 @default.
• W2091274479 hasAuthorship W2091274479A5088518439 @default.
• W2091274479 hasBestOaLocation W20912744791 @default.
• W2091274479 hasConcept C104317684 @default.
• W2091274479 hasConcept C105580179 @default.
• W2091274479 hasConcept C126322002 @default.
• W2091274479 hasConcept C17991360 @default.
• W2091274479 hasConcept C185592680 @default.
• W2091274479 hasConcept C203014093 @default.
• W2091274479 hasConcept C2775862500 @default.
• W2091274479 hasConcept C2777397205 @default.
• W2091274479 hasConcept C2778260677 @default.
• W2091274479 hasConcept C2779134260 @default.
• W2091274479 hasConcept C2780401358 @default.
• W2091274479 hasConcept C55493867 @default.
• W2091274479 hasConcept C71924100 @default.
• W2091274479 hasConcept C98274493 @default.
• W2091274479 hasConceptScore W2091274479C104317684 @default.
• W2091274479 hasConceptScore W2091274479C105580179 @default.
• W2091274479 hasConceptScore W2091274479C126322002 @default.
• W2091274479 hasConceptScore W2091274479C17991360 @default.
• W2091274479 hasConceptScore W2091274479C185592680 @default.
• W2091274479 hasConceptScore W2091274479C203014093 @default.
• W2091274479 hasConceptScore W2091274479C2775862500 @default.
• W2091274479 hasConceptScore W2091274479C2777397205 @default.
• W2091274479 hasConceptScore W2091274479C2778260677 @default.
• W2091274479 hasConceptScore W2091274479C2779134260 @default.
• W2091274479 hasConceptScore W2091274479C2780401358 @default.
• W2091274479 hasConceptScore W2091274479C55493867 @default.
• W2091274479 hasConceptScore W2091274479C71924100 @default.

• next