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• W2091275711 endingPage "20813" @default.
• W2091275711 startingPage "20806" @default.
• W2091275711 abstract "Abstract Members of the AGC subfamily of protein kinases including protein kinase B, p70 S6 kinase, and protein kinase C (PKC) isoforms are activated and/or stabilized by phosphorylation of two residues, one that resides in the T-loop of the kinase domain and the other that is located C-terminal to the kinase domain in a region known as the hydrophobic motif. Atypical PKC isoforms, such as PKCζ, and the PKC-related kinases, like PRK2, are also activated by phosphorylation of their T-loop site but, instead of possessing a phosphorylatable Ser/Thr in their hydrophobic motif, contain an acidic residue. The 3-phosphoinositide-dependent protein kinase (PDK1) activates many members of the AGC subfamily of kinases in vitro, including PKCζ and PRK2 by phosphorylating the T-loop residue. In the present study we demonstrate that the hydrophobic motifs of PKCζ and PKCι, as well as PRK1 and PRK2, interact with the kinase domain of PDK1. Mutation of the conserved residues of the hydrophobic motif of full-length PKCζ, full-length PRK2, or PRK2 lacking its N-terminal regulatory domain abolishes or significantly reduces the ability of these kinases to interact with PDK1 and to become phosphorylated at their T-loop sites in vivo. Furthermore, overexpression of the hydrophobic motif of PRK2 in cells prevents the T-loop phosphorylation and thus inhibits the activation of PRK2 and PKCζ. These findings indicate that the hydrophobic motif of PRK2 and PKCζ acts as a “docking site” enabling the recruitment of PDK1 to these substrates. This is essential for their phosphorylation by PDK1 in cells." @default.
• W2091275711 created "2016-06-24" @default.
• W2091275711 creator A5007413056 @default.
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• W2091275711 creator A5054181982 @default.
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• W2091275711 date "2000-07-01" @default.
• W2091275711 modified "2023-10-18" @default.
• W2091275711 title "A 3-Phosphoinositide-dependent Protein Kinase-1 (PDK1) Docking Site Is Required for the Phosphorylation of Protein Kinase Cζ (PKCζ) and PKC-related Kinase 2 by PDK1" @default.
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• W2091275711 doi "https://doi.org/10.1074/jbc.m000421200" @default.
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