FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2091279703> ?p ?o ?g. }

• W2091279703 endingPage "855" @default.
• W2091279703 startingPage "848" @default.
• W2091279703 abstract "Chlorambucil (CLB) treatment is used in chronic lymphocytic leukemia (CLL) but resistance to CLB develops in association with accelerated repair of CLB-induced DNA damage. Phosphorylated histone H2AX (γH2AX) is located at DNA double-strand break (DSB) sites; furthermore, it recruits and retains damage-responsive proteins. This damage can be repaired by nonhomologous DNA end-joining (NHEJ) and/or homologous recombinational repair (HR) pathways. A key component of NHEJ is the DNA-dependent protein kinase (DNA-PK) complex. Increased DNA-PK activity is associated with resistance to CLB in CLL. We used the specific DNA-PK inhibitor 2-(morpholin-4-yl)-benzo[<i>h</i>]chomen-4-one (NU7026) to sensitize CLL cells to chlorambucil. Our results indicate that in a CLL cell line (I83) and in primary CLL-lymphocytes, chlorambucil plus NU7026 has synergistic cytotoxic activity at nontoxic doses of NU7026. CLB treatment results in G₂/M phase arrest, and NU7026 increases this CLB-induced G₂/M arrest. Moreover, a kinetic time course demonstrates that CLB-induced DNA-PK activity was inhibited by NU7026, providing direct evidence of the ability of NU7026 to inhibit DNA-PK function. DSBs, visualized as γH2AX, were enhanced 24 to 48 h after CLB and further increased by CLB plus NU7026, suggesting that the synergy of the combination is mediated by NU7026 inhibition of DNA-PK with subsequent inhibition of DSB repair." @default.
• W2091279703 created "2016-06-24" @default.
• W2091279703 creator A5005009665 @default.
• W2091279703 creator A5005764534 @default.
• W2091279703 creator A5027266640 @default.
• W2091279703 creator A5049481562 @default.
• W2091279703 creator A5069051267 @default.
• W2091279703 creator A5076559637 @default.
• W2091279703 creator A5091046398 @default.
• W2091279703 date "2007-03-09" @default.
• W2091279703 modified "2023-09-30" @default.
• W2091279703 title "Chlorambucil Cytotoxicity in Malignant B Lymphocytes Is Synergistically Increased by 2-(Morpholin-4-yl)-benzo[<i>h</i>]chomen-4-one (NU7026)-Mediated Inhibition of DNA Double-Strand Break Repair via Inhibition of DNA-Dependent Protein Kinase" @default.
• W2091279703 cites W1979568780 @default.
• W2091279703 cites W1985775217 @default.
• W2091279703 cites W1999235659 @default.
• W2091279703 cites W2012324369 @default.
• W2091279703 cites W2013499751 @default.
• W2091279703 cites W2016222490 @default.
• W2091279703 cites W2018295619 @default.
• W2091279703 cites W2024254896 @default.
• W2091279703 cites W2029526485 @default.
• W2091279703 cites W2034457052 @default.
• W2091279703 cites W2047824377 @default.
• W2091279703 cites W2086389702 @default.
• W2091279703 cites W2088801588 @default.
• W2091279703 cites W2099627146 @default.
• W2091279703 cites W2100121711 @default.
• W2091279703 cites W2111772438 @default.
• W2091279703 cites W2114180794 @default.
• W2091279703 cites W2128680272 @default.
• W2091279703 cites W2130730147 @default.
• W2091279703 cites W2130883309 @default.
• W2091279703 cites W2130952513 @default.
• W2091279703 cites W2151411596 @default.
• W2091279703 cites W2154027835 @default.
• W2091279703 cites W2168244728 @default.
• W2091279703 cites W2169009248 @default.
• W2091279703 cites W2398240122 @default.
• W2091279703 cites W4211220949 @default.
• W2091279703 doi "https://doi.org/10.1124/jpet.106.118356" @default.
• W2091279703 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17351105" @default.
• W2091279703 hasPublicationYear "2007" @default.
• W2091279703 type Work @default.
• W2091279703 sameAs 2091279703 @default.
• W2091279703 citedByCount "53" @default.
• W2091279703 countsByYear W20912797032012 @default.
• W2091279703 countsByYear W20912797032013 @default.
• W2091279703 countsByYear W20912797032014 @default.
• W2091279703 countsByYear W20912797032015 @default.
• W2091279703 countsByYear W20912797032016 @default.
• W2091279703 countsByYear W20912797032017 @default.
• W2091279703 countsByYear W20912797032019 @default.
• W2091279703 countsByYear W20912797032020 @default.
• W2091279703 countsByYear W20912797032021 @default.
• W2091279703 countsByYear W20912797032022 @default.
• W2091279703 countsByYear W20912797032023 @default.
• W2091279703 crossrefType "journal-article" @default.
• W2091279703 hasAuthorship W2091279703A5005009665 @default.
• W2091279703 hasAuthorship W2091279703A5005764534 @default.
• W2091279703 hasAuthorship W2091279703A5027266640 @default.
• W2091279703 hasAuthorship W2091279703A5049481562 @default.
• W2091279703 hasAuthorship W2091279703A5069051267 @default.
• W2091279703 hasAuthorship W2091279703A5076559637 @default.
• W2091279703 hasAuthorship W2091279703A5091046398 @default.
• W2091279703 hasConcept C109316439 @default.
• W2091279703 hasConcept C134935766 @default.
• W2091279703 hasConcept C143425029 @default.
• W2091279703 hasConcept C153911025 @default.
• W2091279703 hasConcept C185592680 @default.
• W2091279703 hasConcept C202751555 @default.
• W2091279703 hasConcept C2776694085 @default.
• W2091279703 hasConcept C2776755627 @default.
• W2091279703 hasConcept C2777866208 @default.
• W2091279703 hasConcept C502942594 @default.
• W2091279703 hasConcept C54355233 @default.
• W2091279703 hasConcept C552990157 @default.
• W2091279703 hasConcept C55493867 @default.
• W2091279703 hasConcept C64927066 @default.
• W2091279703 hasConcept C86803240 @default.
• W2091279703 hasConceptScore W2091279703C109316439 @default.
• W2091279703 hasConceptScore W2091279703C134935766 @default.
• W2091279703 hasConceptScore W2091279703C143425029 @default.
• W2091279703 hasConceptScore W2091279703C153911025 @default.
• W2091279703 hasConceptScore W2091279703C185592680 @default.
• W2091279703 hasConceptScore W2091279703C202751555 @default.
• W2091279703 hasConceptScore W2091279703C2776694085 @default.
• W2091279703 hasConceptScore W2091279703C2776755627 @default.
• W2091279703 hasConceptScore W2091279703C2777866208 @default.
• W2091279703 hasConceptScore W2091279703C502942594 @default.
• W2091279703 hasConceptScore W2091279703C54355233 @default.
• W2091279703 hasConceptScore W2091279703C552990157 @default.
• W2091279703 hasConceptScore W2091279703C55493867 @default.
• W2091279703 hasConceptScore W2091279703C64927066 @default.
• W2091279703 hasConceptScore W2091279703C86803240 @default.
• W2091279703 hasIssue "3" @default.
• W2091279703 hasLocation W20912797031 @default.
• W2091279703 hasLocation W20912797032 @default.
• W2091279703 hasOpenAccess W2091279703 @default.

• next