FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2091279754> ?p ?o ?g. }

• W2091279754 endingPage "5285" @default.
• W2091279754 startingPage "5280" @default.
• W2091279754 abstract "Although LINE-1 (long interspersed nucleotide element-1, L1) retrotransposons comprise 17% of the human genome, an exhaustive search of the December 2001 freeze of the haploid human genome working draft sequence (95% complete) yielded only 90 L1s with intact ORFs. We demonstrate that 38 of 86 (44%) L1s are polymorphic as to their presence in human populations. We cloned 82 (91%) of the 90 L1s and found that 40 of the 82 (49%) are active in a cultured cell retrotransposition assay. From these data, we predict that there are 80-100 retrotransposition-competent L1s in an average human being. Remarkably, 84% of assayed retrotransposition capability was present in six highly active L1s (hot L1s). By comparison, four of five full-length L1s involved in recent human insertions had retrotransposition activity comparable to the six hot L1s in the human genome working draft sequence. Thus, our data indicate that most L1 retrotransposition in the human population stems from hot L1s, with the remaining elements playing a lesser role in genome plasticity." @default.
• W2091279754 created "2016-06-24" @default.
• W2091279754 creator A5016025349 @default.
• W2091279754 creator A5032284991 @default.
• W2091279754 creator A5044492266 @default.
• W2091279754 creator A5055161465 @default.
• W2091279754 creator A5064084333 @default.
• W2091279754 creator A5070968523 @default.
• W2091279754 creator A5076898294 @default.
• W2091279754 date "2003-04-07" @default.
• W2091279754 modified "2023-10-18" @default.
• W2091279754 title "Hot L1s account for the bulk of retrotransposition in the human population" @default.
• W2091279754 cites W1565206912 @default.
• W2091279754 cites W1569932862 @default.
• W2091279754 cites W1944771638 @default.
• W2091279754 cites W1971570045 @default.
• W2091279754 cites W1991333931 @default.
• W2091279754 cites W1991719330 @default.
• W2091279754 cites W1995827174 @default.
• W2091279754 cites W2002190096 @default.
• W2091279754 cites W2003646602 @default.
• W2091279754 cites W2007589425 @default.
• W2091279754 cites W2010426022 @default.
• W2091279754 cites W2012537642 @default.
• W2091279754 cites W2015415562 @default.
• W2091279754 cites W2041152528 @default.
• W2091279754 cites W2052509237 @default.
• W2091279754 cites W2055043387 @default.
• W2091279754 cites W2058480401 @default.
• W2091279754 cites W2059803300 @default.
• W2091279754 cites W2064629259 @default.
• W2091279754 cites W2065461553 @default.
• W2091279754 cites W2072713591 @default.
• W2091279754 cites W2080056745 @default.
• W2091279754 cites W2085758832 @default.
• W2091279754 cites W2089471275 @default.
• W2091279754 cites W2091479795 @default.
• W2091279754 cites W2097706568 @default.
• W2091279754 cites W2102773855 @default.
• W2091279754 cites W2118155162 @default.
• W2091279754 cites W2141382746 @default.
• W2091279754 cites W2144121185 @default.
• W2091279754 cites W2144623802 @default.
• W2091279754 cites W2147321895 @default.
• W2091279754 cites W2150649207 @default.
• W2091279754 cites W2153586836 @default.
• W2091279754 cites W2153593912 @default.
• W2091279754 cites W2154703172 @default.
• W2091279754 cites W2163065744 @default.
• W2091279754 cites W2168909179 @default.
• W2091279754 cites W2262482817 @default.
• W2091279754 cites W310472318 @default.
• W2091279754 cites W4233229084 @default.
• W2091279754 cites W4237165615 @default.
• W2091279754 doi "https://doi.org/10.1073/pnas.0831042100" @default.
• W2091279754 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/154336" @default.
• W2091279754 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12682288" @default.
• W2091279754 hasPublicationYear "2003" @default.
• W2091279754 type Work @default.
• W2091279754 sameAs 2091279754 @default.
• W2091279754 citedByCount "896" @default.
• W2091279754 countsByYear W20912797542012 @default.
• W2091279754 countsByYear W20912797542013 @default.
• W2091279754 countsByYear W20912797542014 @default.
• W2091279754 countsByYear W20912797542015 @default.
• W2091279754 countsByYear W20912797542016 @default.
• W2091279754 countsByYear W20912797542017 @default.
• W2091279754 countsByYear W20912797542018 @default.
• W2091279754 countsByYear W20912797542019 @default.
• W2091279754 countsByYear W20912797542020 @default.
• W2091279754 countsByYear W20912797542021 @default.
• W2091279754 countsByYear W20912797542022 @default.
• W2091279754 countsByYear W20912797542023 @default.
• W2091279754 crossrefType "journal-article" @default.
• W2091279754 hasAuthorship W2091279754A5016025349 @default.
• W2091279754 hasAuthorship W2091279754A5032284991 @default.
• W2091279754 hasAuthorship W2091279754A5044492266 @default.
• W2091279754 hasAuthorship W2091279754A5055161465 @default.
• W2091279754 hasAuthorship W2091279754A5064084333 @default.
• W2091279754 hasAuthorship W2091279754A5070968523 @default.
• W2091279754 hasAuthorship W2091279754A5076898294 @default.
• W2091279754 hasBestOaLocation W20912797541 @default.
• W2091279754 hasConcept C104317684 @default.
• W2091279754 hasConcept C141231307 @default.
• W2091279754 hasConcept C144024400 @default.
• W2091279754 hasConcept C149923435 @default.
• W2091279754 hasConcept C167625842 @default.
• W2091279754 hasConcept C197077220 @default.
• W2091279754 hasConcept C2780530800 @default.
• W2091279754 hasConcept C2908647359 @default.
• W2091279754 hasConcept C47289529 @default.
• W2091279754 hasConcept C4918238 @default.
• W2091279754 hasConcept C54355233 @default.
• W2091279754 hasConcept C7029365 @default.
• W2091279754 hasConcept C86803240 @default.
• W2091279754 hasConceptScore W2091279754C104317684 @default.
• W2091279754 hasConceptScore W2091279754C141231307 @default.
• W2091279754 hasConceptScore W2091279754C144024400 @default.

• next