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- W2091280174 abstract "In one study, sinusoidal whole-body acceleration was used as a noninvasive forcing function to establish the frequency response characteristics of cardiovascular regulation. Unanesthetized (tranquilized), chronically instrumented dogs were exposed to ±2gz acceleration from 0.005 to 0.25 Hz. The participation of neurally mediated cardiac and vascular control mechanisms was examined by comparing the responses of the same animal in a normal (reflexive) state and in a parmacologically blockaded (nonreflexive) state. Integrated neural mechanisms (a) were found to be the most effective in minimizing acceleration-induced, arterial pressure disturbances for frequencies below 0.012 Hz; (b) became progressively out of phase with the disturbances between 0.012 and 0.052 Hz, resulting in decreased effectiveness; and (c) failed to significantly participate for frequencies between 0.052 and 0.25 Hz, where “protection” was provided by the hydraulic and intrinsic biomechanical aspects of the circulatory system. In a second study, whole-body oscillatory acceleration (WBOA) was evaluated as a countermeasure to cardiovascular deconditioning of bed rest. Six adult males were exposed to (a) a control, orthostatic tolerance test (OTT) using 70° head-up tilt for 20 min; (b) an OTT after 6 h of 5° head down bed rest (BR); and (c) an OTT after BR plus 18 min of WBOA (subject supine, 1 and 1.6 gz, 1 Hz, half-sine displacement). Four of the six subjects demonstrated presyncopal episodes during the OTT after BR without WBOA. In all four subjects the presyncopal episodes were either eliminated or the time to occurrence was increased by WBOA. Of the two subjects that did not exhibit presyncopal episodes, one had a reduced orthostatic heart rate response, following WBOA and the other exhibited a higher response. [This research supported by AFOSR Grant 80-0039 and NASA Grant NSF 2318.]" @default.
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- W2091280174 date "1981-11-01" @default.
- W2091280174 modified "2023-10-18" @default.
- W2091280174 title "Cardiovascular responses to low‐frequency whole‐body acceleration" @default.
- W2091280174 doi "https://doi.org/10.1121/1.2018844" @default.
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