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• W2091280282 startingPage "91" @default.
• W2091280282 abstract "Metallothionein (MT) protein and mRNA levels were studied following exposure of rat neonatal primary astrocyte cultures to cadmium chloride (CdCl2). MT mRNA was probed on Northern blots with a 32P labeled synthetic cDNA probe specific for rat MT mRNA. The probe hybridizes to a single mRNA with a size appropriate for MT, approximately 550 bases. Expression of MT-I mRNA in astrocyte monolayers exposed to 2 x 10(-6) M CdCl2 for 6 h was increased approximately 5-fold (9.7 fg/micrograms total RNA) over MT-I mRNA levels in controls (2 fg/micrograms total RNA). MT-I mRNA could also be detected in untreated cells, suggesting constitutive MT expression in these cells. Western-blot analysis revealed a marked increase in MT protein levels upon exposure to CdCl2 (1 x 10(-6) M; 96 h). Consistent with the constitutive expression of MTs both at the mRNA level and protein level, we have also demonstrated a time-dependent increase in MT-immunoreactivity in astrocytes exposed to CdCl2. The present study suggests that astrocytes constitutively express MTs, and that MT-induction by CdCl2 may be an example of a generalized increase in MTs in response to heavy metal exposure, thus protecting astrocytes, and perhaps also indirectly, juxtaposed neurons from the neurotoxic effects of heavy metals." @default.
• W2091280282 created "2016-06-24" @default.
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• W2091280282 date "1995-04-01" @default.
• W2091280282 modified "2023-09-25" @default.
• W2091280282 title "Cadmium chloride (CdCl2)-induced metallothionein (MT) expression in neonatal rat primary astrocyte cultures" @default.
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• W2091280282 doi "https://doi.org/10.1016/0006-8993(95)00170-u" @default.
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• W2091280282 hasPublicationYear "1995" @default.
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