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• W2091281402 abstract "Although heparin/protamine has been the standard anticoagulation regimen in cardiac surgery for decades, it induces negative reactions within the vasculature. Heparin-induced thrombocytopenia (HIT) is a highly prothrombotic immune reaction to heparin that may result in death, limb ischemia leading to amputation, graft occlusion, and other severe thrombotic events. Patients undergoing cardiac surgery are at high risk for HIT antibody seroconversion and at risk for clinical HIT. For patients with acute or subacute HIT and needing urgent cardiac surgery, accepted protocols for alternative, non-heparin anticoagulation are needed. The direct thrombin inhibitor bivalirudin offers promise in this area and is currently being evaluated in multicenter trials as an alternative for heparin/protamine in patients with HIT undergoing cardiac surgery." @default.
• W2091281402 created "2016-06-24" @default.
• W2091281402 creator A5016137124 @default.
• W2091281402 date "2005-07-01" @default.
• W2091281402 modified "2023-09-27" @default.
• W2091281402 title "Update on Heparin-Induced Thrombocytopenia and Cardiovascular Interventions" @default.
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• W2091281402 doi "https://doi.org/10.1053/j.seminhematol.2005.05.014" @default.
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