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• W2091284006 abstract "We examined the effects of lovastatin, a common anti-atherosclerotic drug and a blocker of the cell cycle, on the process of mitosis. It is known that lovastatin induces an arrest or a retardation of the cell cycle in many cell types not only at the G(1)phase, but also at the G(2)/M transition. After 24-48 h incubation of epithelial PtK(2), T24, HeLa cells and fibroblastic L929 cells in the presence of 1. 0-60.0 microm lovastatin, diverse mitotic perturbations have been observed. The most noteworthy phenomena recorded were prometaphase retardation and chromosome lagging during metaphase and anaphase. After the recovery in lovastatin-free media, the cells continued mitosis without any disturbances. Mevalonic acid prevented the effects of lovastatin. We conclude that the effects were specific for lovastatin-induced inhibition of mevalonic acid synthesis. Immunofluorescence studies with anticentromeric antibodies suggested that one of the possible causes of the lovastatin-induced mitotic disorder could be an interference with the development and function of the centromeres." @default.
• W2091284006 created "2016-06-24" @default.
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• W2091284006 date "1999-01-01" @default.
• W2091284006 modified "2023-09-26" @default.
• W2091284006 title "LOVASTATIN INDUCES MITOTIC ABNORMALITIES IN VARIOUS CELL LINES" @default.
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• W2091284006 doi "https://doi.org/10.1006/cbir.1998.0322" @default.
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