Matches in SemOpenAlex for { <https://semopenalex.org/work/W2091284373> ?p ?o ?g. }
- W2091284373 endingPage "e259" @default.
- W2091284373 startingPage "e259" @default.
- W2091284373 abstract "Peripheral T-cell lymphomas not otherwise specified (PTCLs/NOS) are rare and aggressive tumours whose molecular pathogenesis and diagnosis are still challenging. The microRNA (miRNA) profile of 23 PTCLs/NOS was generated and compared with that of normal T-lymphocytes (CD4+, CD8+, naive, activated). The differentially expressed miRNA signature was compared with the gene expression profile (GEP) of the same neoplasms. The obtained gene patterns were tested in an independent cohort of PTCLs/NOS. The miRNA profile of PTCLs/NOS then was compared with that of 10 angioimmunoblastic T-cell lymphomas (AITLs), 6 anaplastic large-cell lymphomas (ALCLs)/ALK+ and 6 ALCLs/ALK−. Differentially expressed miRNAs were validated in an independent set of 20 PTCLs/NOS, 20 AITLs, 19 ALCLs/ALK− and 15 ALCLs/ALK+. Two hundred and thirty-six miRNAs were found to differentiate PTCLs/NOS from activated T-lymphocytes. To assess which miRNAs impacted on GEP, a multistep analysis was performed, which identified all miRNAs inversely correlated to different potential target genes. One of the most discriminant miRNAs was selected and its expression was found to affect the global GEP of the tumours. Moreover, two sets of miRNAs were identified distinguishing PTCL/NOS from AITL and ALCL/ALK−, respectively. The diagnostic accuracy of this tool was very high (83.54%) and its prognostic value validated." @default.
- W2091284373 created "2016-06-24" @default.
- W2091284373 creator A5004960762 @default.
- W2091284373 creator A5006640724 @default.
- W2091284373 creator A5007208015 @default.
- W2091284373 creator A5011647120 @default.
- W2091284373 creator A5015082674 @default.
- W2091284373 creator A5030284302 @default.
- W2091284373 creator A5037413392 @default.
- W2091284373 creator A5043985252 @default.
- W2091284373 creator A5056236667 @default.
- W2091284373 creator A5057836561 @default.
- W2091284373 creator A5057871146 @default.
- W2091284373 creator A5059126313 @default.
- W2091284373 creator A5060227300 @default.
- W2091284373 creator A5060740762 @default.
- W2091284373 creator A5065168136 @default.
- W2091284373 creator A5066783477 @default.
- W2091284373 creator A5072571217 @default.
- W2091284373 creator A5073222946 @default.
- W2091284373 creator A5073323150 @default.
- W2091284373 creator A5078407375 @default.
- W2091284373 creator A5079700663 @default.
- W2091284373 creator A5079709625 @default.
- W2091284373 creator A5088581133 @default.
- W2091284373 date "2014-11-07" @default.
- W2091284373 modified "2023-10-18" @default.
- W2091284373 title "Pathogenetic and diagnostic significance of microRNA deregulation in peripheral T-cell lymphoma not otherwise specified" @default.
- W2091284373 cites W144423133 @default.
- W2091284373 cites W1969940819 @default.
- W2091284373 cites W1972853833 @default.
- W2091284373 cites W1978886141 @default.
- W2091284373 cites W1979925584 @default.
- W2091284373 cites W1981293025 @default.
- W2091284373 cites W1981503243 @default.
- W2091284373 cites W1985503770 @default.
- W2091284373 cites W1986595932 @default.
- W2091284373 cites W1992782604 @default.
- W2091284373 cites W1994192201 @default.
- W2091284373 cites W2014665241 @default.
- W2091284373 cites W2016783244 @default.
- W2091284373 cites W2019103098 @default.
- W2091284373 cites W2019199449 @default.
- W2091284373 cites W2023392825 @default.
- W2091284373 cites W2025444538 @default.
- W2091284373 cites W2030506447 @default.
- W2091284373 cites W2044437847 @default.
- W2091284373 cites W2048178760 @default.
- W2091284373 cites W2065800209 @default.
- W2091284373 cites W2065831401 @default.
- W2091284373 cites W2074525507 @default.
- W2091284373 cites W2079116568 @default.
- W2091284373 cites W2088636620 @default.
- W2091284373 cites W2091490559 @default.
- W2091284373 cites W2092048234 @default.
- W2091284373 cites W2093319553 @default.
- W2091284373 cites W2093804567 @default.
- W2091284373 cites W2099354176 @default.
- W2091284373 cites W2100162337 @default.
- W2091284373 cites W2106196606 @default.
- W2091284373 cites W2111677629 @default.
- W2091284373 cites W2114593202 @default.
- W2091284373 cites W2116272602 @default.
- W2091284373 cites W2130410032 @default.
- W2091284373 cites W2130475053 @default.
- W2091284373 cites W2130622321 @default.
- W2091284373 cites W2130979840 @default.
- W2091284373 cites W2131122962 @default.
- W2091284373 cites W2135810600 @default.
- W2091284373 cites W2142828330 @default.
- W2091284373 cites W2147563499 @default.
- W2091284373 cites W2154086676 @default.
- W2091284373 cites W2162372671 @default.
- W2091284373 cites W2165022781 @default.
- W2091284373 cites W2171873783 @default.
- W2091284373 cites W2322612943 @default.
- W2091284373 cites W2416844197 @default.
- W2091284373 doi "https://doi.org/10.1038/bcj.2014.78" @default.
- W2091284373 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4335255" @default.
- W2091284373 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25382608" @default.
- W2091284373 hasPublicationYear "2014" @default.
- W2091284373 type Work @default.
- W2091284373 sameAs 2091284373 @default.
- W2091284373 citedByCount "26" @default.
- W2091284373 countsByYear W20912843732014 @default.
- W2091284373 countsByYear W20912843732015 @default.
- W2091284373 countsByYear W20912843732016 @default.
- W2091284373 countsByYear W20912843732017 @default.
- W2091284373 countsByYear W20912843732018 @default.
- W2091284373 countsByYear W20912843732019 @default.
- W2091284373 countsByYear W20912843732020 @default.
- W2091284373 countsByYear W20912843732021 @default.
- W2091284373 countsByYear W20912843732022 @default.
- W2091284373 countsByYear W20912843732023 @default.
- W2091284373 crossrefType "journal-article" @default.
- W2091284373 hasAuthorship W2091284373A5004960762 @default.
- W2091284373 hasAuthorship W2091284373A5006640724 @default.
- W2091284373 hasAuthorship W2091284373A5007208015 @default.