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• W2091288471 abstract "In 1994, at the start of the Parasite Genome Initiatives under the auspices of WHO/TDR, only a few hundred sequences of the parasite Trypanosoma cruzi were known, and genomics was an art for large and specialized centers. At the time of writing, 22 796 T. cruzi sequences have been deposited in the public databases, amounting to about 12% of the (diploid) genome, and many collaborating laboratories, previously not involved in genome projects, have acquired new technology and trained people. The training of people was, from the beginning, one of the secondary objectives of the parasite genome projects 1 The Trypanosoma cruzi Genome Initiative (1997) The Trypanosoma cruzi Genome Initiative. Parasitol. Today 13, 16–22 Google Scholar . The complete genome sequence of the T. cruzi parasite is now expected within about four years. Indeed, the National Institutes of Health (NIH; Bethesda, MD, USA) has now provided funding to three Genome Centers [The Institute for Genome Research (TIGR); Seattle Biomedical Research Institute (SBRI) and the University of Uppsala Department of Genetics and Pathology, Sweden] to complete the estimated 43.5 Mb of the haploid genome. Many intriguing details of the genome are emerging and are available at various web sites Box 1. On Trypansoma cruzi and Chagas disease WHO/TDR Chagas disease web site – http://www.who.int/tdr/diseases/chagas.html DBBM-Fiocruz Chagas disease site – http://www.dbbm.fiocruz.br/tropical/chagas/chagas.html Institut Pasteur (Paris, France) mirror site on T. cruzi – http://www.pasteur.fr/recherche/unites/tcruzi/ Trypanosoma cruzi Genome Network Home page – http://www.dbbm.fiocruz.br/TcruziDB/ Mirror site at Institut Pasteur – http://www.pasteur.fr/recherche/unites/tcruzi/ Strains and karyotypes – http://www.dbbm.fiocruz.br/TcruziDB/strainka.html Maps and markers – http://www.dbbm.fiocruz.br/TcruziDB/mapmark.html Sequences – http://www.dbbm.fiocruz.br/TcruziDB/sequence.html Proteomics, genetics and functional analysis – http://www.dbbm.fiocruz.br/TcruziDB/postgeno.html T. cruzi Genome Database (TcruziDB) – http://www.dbbm.fiocruz.br/TcruziDB/database.html Other Trypanosoma cruzi Genome links and services EST sequence data at University of Uppsala (Sweden) – http://www.genpat.uu.se/tryp/tryp.html Genomic sequencing effort at University of Uppsala – http://cruzi.genpat.uu.se/ EST and GSS sequencing effort at the National University of General San Martı́n (Argentina) – http://www.iib.unsam.edu.ar/genomelab/tcruzi CL-Brener whole genome sequencing effort at TIGR (USA) – http://www.tigr.org/tdb/mdb/tcdb/ EST cluster analysis (University of Uppsala, Sweden) – http://web.genpat.uu.se/TcruziESTc/ EST clusters and queries (University of Pennsylvania, USA) – http://www.cbil.upenn.edu/ParaDBs/T_cruzi/ BLAST search against deposited T. cruzi sequences (EBI, UK) – http://www2.ebi.ac.uk/blast2/parasites.html BLAST search against progressing BAC sequences (TIGR, USA) – http://www.tigr.org/cgibin/BlastSearch/blast.cgi? Six frame translation search against T. cruzi sequences (EBI) –http://www.ebi.ac.uk/cgi-bin/parasites/sixframe.p T. cruzi proteomics (EBI) – http://www.ebi.ac.uk/parasites/Tcgn/proteome/proteome.html Parasite proteome keyword search – http://www.ebi.ac.uk/cgi-bin/parasites/class_search.p Parasite proteome motif search – http://www.ebi.ac.uk/cgi-bin/parasites/motif_search.p Other useful links Parasite genome pages – http://www.ebi.ac.uk/parasites/parasite-genome.html Leishmania Genome Network – http://www.ebi.ac.uk/parasites/leish.html T. brucei Genome Network – http://parsun1.path.cam.ac.uk/ On Trypansoma cruzi and Chagas disease WHO/TDR Chagas disease web site – http://www.who.int/tdr/diseases/chagas.html DBBM-Fiocruz Chagas disease site – http://www.dbbm.fiocruz.br/tropical/chagas/chagas.html Institut Pasteur (Paris, France) mirror site on T. cruzi – http://www.pasteur.fr/recherche/unites/tcruzi/ Trypanosoma cruzi Genome Network Home page – http://www.dbbm.fiocruz.br/TcruziDB/ Mirror site at Institut Pasteur – http://www.pasteur.fr/recherche/unites/tcruzi/ Strains and karyotypes – http://www.dbbm.fiocruz.br/TcruziDB/strainka.html Maps and markers – http://www.dbbm.fiocruz.br/TcruziDB/mapmark.html Sequences – http://www.dbbm.fiocruz.br/TcruziDB/sequence.html Proteomics, genetics and functional analysis – http://www.dbbm.fiocruz.br/TcruziDB/postgeno.html T. cruzi Genome Database (TcruziDB) – http://www.dbbm.fiocruz.br/TcruziDB/database.html Other Trypanosoma cruzi Genome links and services EST sequence data at University of Uppsala (Sweden) – http://www.genpat.uu.se/tryp/tryp.html Genomic sequencing effort at University of Uppsala – http://cruzi.genpat.uu.se/ EST and GSS sequencing effort at the National University of General San Martı́n (Argentina) – http://www.iib.unsam.edu.ar/genomelab/tcruzi CL-Brener whole genome sequencing effort at TIGR (USA) – http://www.tigr.org/tdb/mdb/tcdb/ EST cluster analysis (University of Uppsala, Sweden) – http://web.genpat.uu.se/TcruziESTc/ EST clusters and queries (University of Pennsylvania, USA) – http://www.cbil.upenn.edu/ParaDBs/T_cruzi/ BLAST search against deposited T. cruzi sequences (EBI, UK) – http://www2.ebi.ac.uk/blast2/parasites.html BLAST search against progressing BAC sequences (TIGR, USA) – http://www.tigr.org/cgibin/BlastSearch/blast.cgi? Six frame translation search against T. cruzi sequences (EBI) –http://www.ebi.ac.uk/cgi-bin/parasites/sixframe.p T. cruzi proteomics (EBI) – http://www.ebi.ac.uk/parasites/Tcgn/proteome/proteome.html Parasite proteome keyword search – http://www.ebi.ac.uk/cgi-bin/parasites/class_search.p Parasite proteome motif search – http://www.ebi.ac.uk/cgi-bin/parasites/motif_search.p Other useful links Parasite genome pages – http://www.ebi.ac.uk/parasites/parasite-genome.html Leishmania Genome Network – http://www.ebi.ac.uk/parasites/leish.html T. brucei Genome Network – http://parsun1.path.cam.ac.uk/" @default.
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• W2091288471 title "The Trypanosoma cruzi Genome Initiative on the Web" @default.
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