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- W2091288703 abstract "Two species of metallothioneins were isolated from both normal and Menkes kinky hair disease (MKHD) patient livers. Atomic absorption determination of metals indicated that the patient liver metallothioneins had lower copper and cadmium content than normals. Isotope exchange studies, carried out by incubating native metallothioneins with copper-64 or cadmium-109 demonstrated a decreased affinity for copper and an increased affinity for cadmium in both MKHD metallothioneins. An hypothesis is proposed in which metallothionein functions as an intracellular copper carrier and is responsible for the transport of copper between the cells and the surrounding. Change in the copper affinity of the metallothioneins was suggested to be the major abnormality in MKHD." @default.
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- W2091288703 date "1978-09-01" @default.
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- W2091288703 title "Metal-binding studies of metallothioneins in Menkes kinky hair disease" @default.
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- W2091288703 doi "https://doi.org/10.1016/0009-8981(78)90426-6" @default.
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