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• W2091288913 abstract "Glucose sensitive membranes which increase their permeability in the presence of glucose have been developed. The potential of these membranes to deliver insulin at rates controlled by the external glucose concentration is assessed in this study. In order to perform meaningful membrane transport measurements of 125I-labelled insulin, it has been found necessary to thoroughly remove unbound 125 I. Substantial errors in the apparent permeation rate will be obtained if this unbound material is not completely removed. Membranes that have insulin permeation rates that are great enough to achieve estimated physiologic insulin requirements must have a macroporous as opposed to homogenous structure. Macroporous membranes containing amine groups and entrapped glucose oxidase have been found to alter insulin permeability in response to external glucose concentration." @default.
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• W2091288913 date "1985-11-01" @default.
• W2091288913 modified "2023-10-14" @default.
• W2091288913 title "Glucose sensitive membranes for controlled delivery of insulin: Insulin transport studies" @default.
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• W2091288913 doi "https://doi.org/10.1016/0168-3659(85)90041-0" @default.
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