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- W2091288950 abstract "Three different prime-boost immunization protocols were tested in rabbits and their immune response was evaluated and compared with the final aim of identifying a vaccine strategy that might be able to protect non-human primates from infection with the pathogenic chimera simian/human immunodeficiency virus (SHIV)89.6P. Protocols were based on priming with two fowlpox (FP) recombinant vectors and two expression plasmids, which express either the simian immunodeficiency virus (SIV)mac239 gag/pol or the human immunodeficiency virus (HIV-1)env89.6P genes, followed by boosting with virus-like particles (VLP). All protocols were effective in eliciting homologous neutralizing Ab and highlighted the efficacy of VLP boosting. The FP vector was less efficient than plasmid DNA in inducing Ab against the gag core proteins. Analysis of cytokine expression 5 months after last immunization indicated that priming with pcDNA3gag/polSIV and FPenv89.6P followed by VLP boosting generated a T helper (Th0) profile and a good Ab titer, suggesting a potential protocol to be tested in the SHIV-macaque model of HIV-1 infection." @default.
- W2091288950 created "2016-06-24" @default.
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- W2091288950 date "2003-05-01" @default.
- W2091288950 modified "2023-09-23" @default.
- W2091288950 title "Comparative analysis of immune responses and cytokine profiles elicited in rabbits by the combined use of recombinant fowlpox viruses, plasmids and virus-like particles in prime-boost vaccination protocols against SHIV*1" @default.
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- W2091288950 doi "https://doi.org/10.1016/s0264-410x(02)00773-9" @default.
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