Matches in SemOpenAlex for { <https://semopenalex.org/work/W2091289089> ?p ?o ?g. }
- W2091289089 endingPage "271" @default.
- W2091289089 startingPage "260" @default.
- W2091289089 abstract "Wiskott-Aldrich Syndrome proteins (WASp) serve as important regulators of cytoskeletal organization and function. These modular proteins, which are well-conserved among eukaryotic species, act to promote actin filament assembly in response to cues from various signal transduction pathways. Genetic analysis has revealed a requirement for the single Drosophila homolog, Wasp (Wsp), in cell-fate decisions governing specific neuronal lineages. We have used this unique developmental context to assess the contributions of established signaling and cytoskeletal partners of WASp. We present biochemical and genetic evidence that, as expected, Drosophila Wsp performs its developmental role via the Arp2/3 complex, indicating conservation of the cytoskeletal aspect of Wsp function in vivo. In contrast, we find that association with the key signaling molecules CDC42 and PIP2 is not an essential requirement, implying that activation of Wsp function in vivo depends on additional or alternative signaling pathways." @default.
- W2091289089 created "2016-06-24" @default.
- W2091289089 creator A5007110381 @default.
- W2091289089 creator A5021778634 @default.
- W2091289089 creator A5036396627 @default.
- W2091289089 date "2002-03-01" @default.
- W2091289089 modified "2023-10-10" @default.
- W2091289089 title "Conserved Interactions with Cytoskeletal but Not Signaling Elements Are an Essential Aspect of Drosophila Wasp Function" @default.
- W2091289089 cites W1507572058 @default.
- W2091289089 cites W1524475817 @default.
- W2091289089 cites W1575892864 @default.
- W2091289089 cites W1790815665 @default.
- W2091289089 cites W1921966622 @default.
- W2091289089 cites W1972974751 @default.
- W2091289089 cites W1978525637 @default.
- W2091289089 cites W1983503431 @default.
- W2091289089 cites W1995098283 @default.
- W2091289089 cites W2001779234 @default.
- W2091289089 cites W2006996074 @default.
- W2091289089 cites W2007586038 @default.
- W2091289089 cites W2009068509 @default.
- W2091289089 cites W2025138357 @default.
- W2091289089 cites W2031123547 @default.
- W2091289089 cites W2031183440 @default.
- W2091289089 cites W2032418607 @default.
- W2091289089 cites W2034499208 @default.
- W2091289089 cites W2036123452 @default.
- W2091289089 cites W2044084413 @default.
- W2091289089 cites W2046816603 @default.
- W2091289089 cites W2049811270 @default.
- W2091289089 cites W2049811440 @default.
- W2091289089 cites W2059161447 @default.
- W2091289089 cites W2067975978 @default.
- W2091289089 cites W2070282050 @default.
- W2091289089 cites W2076808220 @default.
- W2091289089 cites W2078384542 @default.
- W2091289089 cites W2079099921 @default.
- W2091289089 cites W2082677295 @default.
- W2091289089 cites W2095393268 @default.
- W2091289089 cites W2107625881 @default.
- W2091289089 cites W2108239878 @default.
- W2091289089 cites W2108483330 @default.
- W2091289089 cites W2109320169 @default.
- W2091289089 cites W2110643873 @default.
- W2091289089 cites W2110726109 @default.
- W2091289089 cites W2113249117 @default.
- W2091289089 cites W2118537560 @default.
- W2091289089 cites W2118875203 @default.
- W2091289089 cites W2130526838 @default.
- W2091289089 cites W2139094884 @default.
- W2091289089 cites W2142276972 @default.
- W2091289089 cites W2155653297 @default.
- W2091289089 cites W2157815908 @default.
- W2091289089 cites W2166710017 @default.
- W2091289089 cites W2184506751 @default.
- W2091289089 cites W2187370769 @default.
- W2091289089 cites W4247900088 @default.
- W2091289089 doi "https://doi.org/10.1006/dbio.2002.0571" @default.
- W2091289089 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11884035" @default.
- W2091289089 hasPublicationYear "2002" @default.
- W2091289089 type Work @default.
- W2091289089 sameAs 2091289089 @default.
- W2091289089 citedByCount "46" @default.
- W2091289089 countsByYear W20912890892012 @default.
- W2091289089 countsByYear W20912890892014 @default.
- W2091289089 countsByYear W20912890892015 @default.
- W2091289089 countsByYear W20912890892016 @default.
- W2091289089 countsByYear W20912890892019 @default.
- W2091289089 countsByYear W20912890892020 @default.
- W2091289089 countsByYear W20912890892021 @default.
- W2091289089 crossrefType "journal-article" @default.
- W2091289089 hasAuthorship W2091289089A5007110381 @default.
- W2091289089 hasAuthorship W2091289089A5021778634 @default.
- W2091289089 hasAuthorship W2091289089A5036396627 @default.
- W2091289089 hasBestOaLocation W20912890891 @default.
- W2091289089 hasConcept C104317684 @default.
- W2091289089 hasConcept C125705527 @default.
- W2091289089 hasConcept C14036430 @default.
- W2091289089 hasConcept C142669718 @default.
- W2091289089 hasConcept C1491633281 @default.
- W2091289089 hasConcept C2780040266 @default.
- W2091289089 hasConcept C2780104201 @default.
- W2091289089 hasConcept C2780939953 @default.
- W2091289089 hasConcept C2993400109 @default.
- W2091289089 hasConcept C54355233 @default.
- W2091289089 hasConcept C62478195 @default.
- W2091289089 hasConcept C86803240 @default.
- W2091289089 hasConcept C95444343 @default.
- W2091289089 hasConceptScore W2091289089C104317684 @default.
- W2091289089 hasConceptScore W2091289089C125705527 @default.
- W2091289089 hasConceptScore W2091289089C14036430 @default.
- W2091289089 hasConceptScore W2091289089C142669718 @default.
- W2091289089 hasConceptScore W2091289089C1491633281 @default.
- W2091289089 hasConceptScore W2091289089C2780040266 @default.
- W2091289089 hasConceptScore W2091289089C2780104201 @default.
- W2091289089 hasConceptScore W2091289089C2780939953 @default.
- W2091289089 hasConceptScore W2091289089C2993400109 @default.
- W2091289089 hasConceptScore W2091289089C54355233 @default.