FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2091290890> ?p ?o ?g. }

• W2091290890 endingPage "296" @default.
• W2091290890 startingPage "277" @default.
• W2091290890 abstract "Most studies on resistance of organisms to xenobiotics have focused on mechanisms which metabolize the compound to some other hopefully nontoxic derivative. Another defense mechanism has recently been described in which a multixenobiotic transport protein exports moderately hydrophobic compounds from the cells, thus reducing their accumulation in the cells. In this study we describe a simple fluorescent dye assay to measure multixenobiotic transport activity in the gills of the mussel Mytilus californianus. The assay is also used to identify potential substrates or inhibitors of the transport mechanism by their ability to inhibit dye transport from the cells (resulting in their increased fluorescence). Several moderately hydrophobic pesticides including DCPA or dacthal, chlorbenside, pentachlorophenol, and CDEC or sulfallate do inhibit dye efflux from gill cells indicating that they are substrates or inhibitors, but the more hydrophobic xenobiotics DDT, DDD, DDE, and Aroclor 1254 do not, indicating that they are not substrates. We also confirm by direct chemical analysis that DCPA is exported from the cell by the multixenobiotic defense mechanism; DCPA levels in mussel gills are enhanced when an inhibitor of the transporter is present. M. californianus gills also have a protein of 170 kDa that is immunologically related to the mammalian multidrug transport protein (responsible for multidrug resistance, a phenomenon similar to the multixenobiotic defense mechanism). M. californianus and other marine organisms may use multixenobiotic transport to reduce the accumulation of potentially harmful environmental xenobiotics in their cells. The implications of these results for biomonitoring studies, such as the Mussel Watch Program, are discussed." @default.
• W2091290890 created "2016-06-24" @default.
• W2091290890 creator A5016041308 @default.
• W2091290890 creator A5022140700 @default.
• W2091290890 creator A5026381750 @default.
• W2091290890 creator A5035608405 @default.
• W2091290890 creator A5046761651 @default.
• W2091290890 creator A5079000994 @default.
• W2091290890 date "1995-04-01" @default.
• W2091290890 modified "2023-09-27" @default.
• W2091290890 title "Characterization of multixenobiotic/multidrug transport in the gills of the mussel Mytilus californianus and identification of environmental substrates" @default.
• W2091290890 cites W1499694712 @default.
• W2091290890 cites W1531911812 @default.
• W2091290890 cites W1585153381 @default.
• W2091290890 cites W1595188935 @default.
• W2091290890 cites W1969422973 @default.
• W2091290890 cites W1969795656 @default.
• W2091290890 cites W1975501157 @default.
• W2091290890 cites W1977782761 @default.
• W2091290890 cites W1986537087 @default.
• W2091290890 cites W1997241897 @default.
• W2091290890 cites W2014691271 @default.
• W2091290890 cites W2018019490 @default.
• W2091290890 cites W2024065586 @default.
• W2091290890 cites W2027506630 @default.
• W2091290890 cites W2027708100 @default.
• W2091290890 cites W2034486771 @default.
• W2091290890 cites W2044254973 @default.
• W2091290890 cites W2049772927 @default.
• W2091290890 cites W2051790091 @default.
• W2091290890 cites W2053265284 @default.
• W2091290890 cites W2053379947 @default.
• W2091290890 cites W2068927629 @default.
• W2091290890 cites W2071789553 @default.
• W2091290890 cites W2073987248 @default.
• W2091290890 cites W2077314516 @default.
• W2091290890 cites W2079694677 @default.
• W2091290890 cites W2081587095 @default.
• W2091290890 cites W2097878215 @default.
• W2091290890 cites W2105116206 @default.
• W2091290890 cites W2118234018 @default.
• W2091290890 cites W2135667467 @default.
• W2091290890 cites W2201565531 @default.
• W2091290890 cites W2412039185 @default.
• W2091290890 cites W2504070894 @default.
• W2091290890 cites W35929032 @default.
• W2091290890 doi "https://doi.org/10.1016/0166-445x(94)00070-7" @default.
• W2091290890 hasPublicationYear "1995" @default.
• W2091290890 type Work @default.
• W2091290890 sameAs 2091290890 @default.
• W2091290890 citedByCount "95" @default.
• W2091290890 countsByYear W20912908902012 @default.
• W2091290890 countsByYear W20912908902013 @default.
• W2091290890 countsByYear W20912908902014 @default.
• W2091290890 countsByYear W20912908902015 @default.
• W2091290890 countsByYear W20912908902016 @default.
• W2091290890 countsByYear W20912908902017 @default.
• W2091290890 countsByYear W20912908902018 @default.
• W2091290890 countsByYear W20912908902022 @default.
• W2091290890 crossrefType "journal-article" @default.
• W2091290890 hasAuthorship W2091290890A5016041308 @default.
• W2091290890 hasAuthorship W2091290890A5022140700 @default.
• W2091290890 hasAuthorship W2091290890A5026381750 @default.
• W2091290890 hasAuthorship W2091290890A5035608405 @default.
• W2091290890 hasAuthorship W2091290890A5046761651 @default.
• W2091290890 hasAuthorship W2091290890A5079000994 @default.
• W2091290890 hasBestOaLocation W20912908901 @default.
• W2091290890 hasConcept C115448650 @default.
• W2091290890 hasConcept C161153951 @default.
• W2091290890 hasConcept C181199279 @default.
• W2091290890 hasConcept C18903297 @default.
• W2091290890 hasConcept C200082930 @default.
• W2091290890 hasConcept C2779909984 @default.
• W2091290890 hasConcept C2779987062 @default.
• W2091290890 hasConcept C2909208804 @default.
• W2091290890 hasConcept C505870484 @default.
• W2091290890 hasConcept C55493867 @default.
• W2091290890 hasConcept C86803240 @default.
• W2091290890 hasConcept C95444343 @default.
• W2091290890 hasConceptScore W2091290890C115448650 @default.
• W2091290890 hasConceptScore W2091290890C161153951 @default.
• W2091290890 hasConceptScore W2091290890C181199279 @default.
• W2091290890 hasConceptScore W2091290890C18903297 @default.
• W2091290890 hasConceptScore W2091290890C200082930 @default.
• W2091290890 hasConceptScore W2091290890C2779909984 @default.
• W2091290890 hasConceptScore W2091290890C2779987062 @default.
• W2091290890 hasConceptScore W2091290890C2909208804 @default.
• W2091290890 hasConceptScore W2091290890C505870484 @default.
• W2091290890 hasConceptScore W2091290890C55493867 @default.
• W2091290890 hasConceptScore W2091290890C86803240 @default.
• W2091290890 hasConceptScore W2091290890C95444343 @default.
• W2091290890 hasIssue "4" @default.
• W2091290890 hasLocation W20912908901 @default.
• W2091290890 hasOpenAccess W2091290890 @default.
• W2091290890 hasPrimaryLocation W20912908901 @default.
• W2091290890 hasRelatedWork W1981818864 @default.
• W2091290890 hasRelatedWork W2015461373 @default.
• W2091290890 hasRelatedWork W2023960461 @default.

• next