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- W2091294502 abstract "Abstract In adult patients, amifostine appears to ameliorate cisplatin‐related nephrotoxicity and ototoxicity. We assessed the safety and efficacy of amifostine in 11 children with newly diagnosed medulloblastoma/primitive neuroectodermal tumor treated with radiotherapy and vincristine, lomustine, and cisplatin. Amifostine was administered immediately prior to and 4 hr into the cisplatin infusion. Amifostine caused assymptomatic hypotension and hypocalcemia in 18 and 82% of patients, respectively. Despite amifostine use, 78% of patients developed significant ototoxicity. Although relatively well tolerated, amifostine does not appear to have a major impact on ameliorating the risk of developing significant nephro‐ and ototoxicity in children with medulloblastoma. Larger studies will help clarify these findings. Pediatr Blood Cancer 2004;43:780–784. © 2004 Wiley‐Liss, Inc." @default.
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- W2091294502 date "2004-07-12" @default.
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- W2091294502 title "Amifostine for children with medulloblastoma treated with cisplatin-based chemotherapy" @default.
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- W2091294502 doi "https://doi.org/10.1002/pbc.20132" @default.
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