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- W2091297004 abstract "<h3>In Reply.—</h3> Schinagl is making a semantic stretch. To prolong remission is not the same as to maintain it. Sulfasalazine can only prolong remission in patients willing to give themselves daily enemas between acute attacks. Those acute attacks mean remission is not being maintained. Phillips et al have confused enthusiasm for the search for better treatment with enthusiasm for the use of drugs being studied. The article contains specific warnings about prolonged use of these drugs, especially cyclosporine and methotrexate. These drugs are by no means accepted as effective and safe, and all have possible adverse reactions that can be serious, says Stephen Hanauer, MD, in the article. It will take years of follow-up to know whether any of these treatments prevent progression to cancer. Meanwhile, the enthusiasm for surgery expressed by Phillips et al is shared by few patients. The aversion patients have to having their colons cut up" @default.
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- W2091297004 date "1990-12-05" @default.
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- W2091297004 title "New Approaches for Inflammatory Bowel Disease-Reply" @default.
- W2091297004 doi "https://doi.org/10.1001/jama.1990.03450210036024" @default.
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