FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2091297229> ?p ?o ?g. }

• W2091297229 endingPage "S223" @default.
• W2091297229 startingPage "S223" @default.
• W2091297229 abstract "FJB and MKC contributed equally to this study. We have previously reported in detail the first gene transfer method to achieve virtually 100% myofiber transduction in proximal limb muscles of the dog - thus establishing the feasibility of high efficiency somatic gene transfer to striated muscle in a large mammal. Our group is currently undertaking to study the efficacy of therapeutic gene delivery in a canine model for Duchenne Muscular Dystrophy. Towards this end, our group has developed a novel, completely non-invasive, non-volitional assessment of proximal (quadriceps) muscle strength in the dystrophic dog using magnetic stimulation of the femoral nerve. Using a computer controlled 1.4 Tesla electro- magnetic coil capable of inductively triggering isolated single twitches up to complete fusion and sustained supramax titanic contraction, we initially studied quadriceps force produced by inductive magnetic stimulation of the femoral nerve in normal dogs with the result that supramaximal stimulation is rapidly achieved and well tolerated in lightly sedated dogs. Following this, we repeated the same experiment on a representative set of dystrophic dogs from the GRMD colony. Again the magnetic stimulation was well tolerated in this context, importantly in the oldest dog studied, a lightly sedated 18 month old GRMD male. Statistical analysis of the quadriceps tetanic force data for normal and GRMD dogs reveals that the general approach is highly reproducible. The average 8 month old GRMD dog tested had a maximal quadriceps force of 1.79 N/kg body weight, only 46% that of even the youngest normal dogs tested (3.91 N/kg at 7 weeks). In contrast, the previous tests of relative force showed that GRMD dogs doubled their strength in the TA/EDL muscle group from 3 to 6 months and thereafter maintained approximately 100% of the value found in the youngest normal dogs tested. Importantly, for the quadriceps force as measured by the present systems, the left versus right limb correlation is even better than that previously observed for tibiotarsal extension, and can be assessed in younger dogs. Based on our current experience we anticipate straightforward extrapolation of this approach to the measurement of quadriceps force in pups at 4 weeks, providing baseline information before the onset of clinically overt muscle weakness. We anticipate that the use of this test sequence in the DMD large animal model will allow us to define the response to regional gene therapy in terms of clinically relevant, statistically robust efficacy endpoints that are internally consistent and replicative." @default.
• W2091297229 created "2016-06-24" @default.
• W2091297229 creator A5002468156 @default.
• W2091297229 creator A5008067926 @default.
• W2091297229 creator A5008088558 @default.
• W2091297229 creator A5011910765 @default.
• W2091297229 creator A5050498414 @default.
• W2091297229 creator A5069016026 @default.
• W2091297229 date "2006-01-01" @default.
• W2091297229 modified "2023-09-26" @default.
• W2091297229 title "579. Non-Invasive Measurement of Maximal Strength in the Normal and Dystrophic Dog Quadriceps Using Magnetic Stimulation of the Femoral Nerve" @default.
• W2091297229 doi "https://doi.org/10.1016/j.ymthe.2006.08.652" @default.
• W2091297229 hasPublicationYear "2006" @default.
• W2091297229 type Work @default.
• W2091297229 sameAs 2091297229 @default.
• W2091297229 citedByCount "0" @default.
• W2091297229 crossrefType "journal-article" @default.
• W2091297229 hasAuthorship W2091297229A5002468156 @default.
• W2091297229 hasAuthorship W2091297229A5008067926 @default.
• W2091297229 hasAuthorship W2091297229A5008088558 @default.
• W2091297229 hasAuthorship W2091297229A5011910765 @default.
• W2091297229 hasAuthorship W2091297229A5050498414 @default.
• W2091297229 hasAuthorship W2091297229A5069016026 @default.
• W2091297229 hasBestOaLocation W20912972291 @default.
• W2091297229 hasConcept C105702510 @default.
• W2091297229 hasConcept C126322002 @default.
• W2091297229 hasConcept C136229726 @default.
• W2091297229 hasConcept C24998067 @default.
• W2091297229 hasConcept C2780394545 @default.
• W2091297229 hasConcept C3018430268 @default.
• W2091297229 hasConcept C71924100 @default.
• W2091297229 hasConceptScore W2091297229C105702510 @default.
• W2091297229 hasConceptScore W2091297229C126322002 @default.
• W2091297229 hasConceptScore W2091297229C136229726 @default.
• W2091297229 hasConceptScore W2091297229C24998067 @default.
• W2091297229 hasConceptScore W2091297229C2780394545 @default.
• W2091297229 hasConceptScore W2091297229C3018430268 @default.
• W2091297229 hasConceptScore W2091297229C71924100 @default.
• W2091297229 hasLocation W20912972291 @default.
• W2091297229 hasOpenAccess W2091297229 @default.
• W2091297229 hasPrimaryLocation W20912972291 @default.
• W2091297229 hasRelatedWork W1985672831 @default.
• W2091297229 hasRelatedWork W1995168293 @default.
• W2091297229 hasRelatedWork W2048699749 @default.
• W2091297229 hasRelatedWork W2051856329 @default.
• W2091297229 hasRelatedWork W2055606529 @default.
• W2091297229 hasRelatedWork W2056308317 @default.
• W2091297229 hasRelatedWork W2097201382 @default.
• W2091297229 hasRelatedWork W2156860680 @default.
• W2091297229 hasRelatedWork W2162380095 @default.
• W2091297229 hasRelatedWork W2612727090 @default.
• W2091297229 hasVolume "13" @default.
• W2091297229 isParatext "false" @default.
• W2091297229 isRetracted "false" @default.
• W2091297229 magId "2091297229" @default.
• W2091297229 workType "article" @default.