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• W2091297910 abstract "BACKGROUND & AIMS Eosinophilic esophagitis (EoE) can be currently diagnosed upon histopathology and a normal pH monitoring. We aimed to evaluate the prevalence of EoE before and after proton pump inhibitors (PPI) therapy and the accuracy of the aforementioned tests compared to systematic clinicopathologic follow-up on PPIs METHODS Biopsies of upper-mid esophagus were taken in 712 symptomatic adults referred for endoscopy, regardless of endoscopic findings. Patients with ≥ 15 eosinophils per high power field (eo/HPF) were treated with rabeprazole 20 mg b.i.d for two months. Gastroesophageal reflux disease (GERD) was defined by clinicopathologic remission on PPIs. RESULTS 35 patients (4,9%) had ≥ 15 eo/HPF, 55% had allergic history and 70% had food impaction or dysphagia as primary complaint. 26 patients (75%) were diagnosed of GERD after PPI treatment, including 2 with normal pH monitoring. The prevalence of ≥ 15 eo/HPF in 20 eo/HPF, 46% and 39% for > 24 eo/HPF, 64% and 50% for 35 eo/HPF). Clinical remission without histological response occurred in 5 out of 9 EoE patients after PPIs. CONCLUSIONS 75% of symptomatic adults with≥ 15 eo/HPF are responsive to acid suppression, irrespective of acid exposure time, eosinophil count or histopathologic features. EoEmay be overestimated without systematic clinicopathologic reevaluation on PPI therapy." @default.
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• W2091297910 date "2010-05-01" @default.
• W2091297910 modified "2023-10-18" @default.
• W2091297910 title "S1073 Systematic Clinicopathological Follow-up on High-Dose Acid Suppression is Mandatory to Avoid Eosinophilic Esophagitis Overestimation in Adults" @default.
• W2091297910 doi "https://doi.org/10.1016/s0016-5085(10)60789-5" @default.
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